7MI6
| Yeast dynein motor domain in the presence of a pyrazolo-pyrimidinone-based compound, Model 1 | Descriptor: | (8S)-6-(3-bromophenoxy)-2-[1-(4-chlorophenyl)cyclopropyl]-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carbonitrile, ADENOSINE-5'-TRIPHOSPHATE, Fusion protein of Dynein and Endolysin, ... | Authors: | Santarossa, C.C, Urnavicius, L, Coudray, N, Ekeirt, D.C, Bhabha, G, Kapoor, T.M. | Deposit date: | 2021-04-16 | Release date: | 2021-05-26 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Targeting allostery in the Dynein motor domain with small molecule inhibitors. Cell Chem Biol, 28, 2021
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6RLA
| Structure of the dynein-2 complex; motor domains | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Toropova, K, Zalyte, R, Mukhopadhyay, A.G, Mladenov, M, Carter, A.P, Roberts, A.J. | Deposit date: | 2019-05-01 | Release date: | 2019-08-28 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structure of the dynein-2 complex and its assembly with intraflagellar transport trains. Nat.Struct.Mol.Biol., 26, 2019
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8RGH
| Structure of dynein-2 intermediate chain DYNC2I1 (WDR60) in complex with the dynein-2 heavy chain DYNC2H1. | Descriptor: | Cytoplasmic dynein 2 intermediate chain 1, Cytoplasmic dynein 2 intermediate chain 2, Cytoplasmic dynein 2 light intermediate chain 1, ... | Authors: | Mukhopadhyay, A.G, Toropova, K, Daly, L, Wells, J, Vuolo, L, Seda, M, Jenkins, D, Stephens, D.J, Roberts, A.J. | Deposit date: | 2023-12-13 | Release date: | 2024-03-20 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structure and tethering mechanism of dynein-2 intermediate chains in intraflagellar transport. Embo J., 43, 2024
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8PR3
| Cytoplasmic dynein-1 heavy chain bound to JIP3-RH1 | Descriptor: | C-Jun-amino-terminal kinase-interacting protein 3, Cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein 1 intermediate chain 2, ... | Authors: | Singh, K, Lau, C.K, Manigrasso, G, Gassmann, R, Carter, A.P. | Deposit date: | 2023-07-12 | Release date: | 2024-03-27 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Molecular mechanism of dynein-dynactin complex assembly by LIS1. Science, 383, 2024
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6SC2
| Structure of the dynein-2 complex; IFT-train bound model | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 2 light intermediate chain 1, ... | Authors: | Toropova, K, Zalyte, R, Mukhopadhyay, A.G, Mladenov, M, Carter, A.P, Roberts, A.J. | Deposit date: | 2019-07-23 | Release date: | 2019-09-04 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structure of the dynein-2 complex and its assembly with intraflagellar transport trains. Nat.Struct.Mol.Biol., 26, 2019
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7Z8J
| Cytoplasmic dynein (A2) bound to BICDR1 | Descriptor: | BICD family-like cargo adapter 1, Cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein 1 intermediate chain 2, ... | Authors: | Chaaban, S, Carter, A.P. | Deposit date: | 2022-03-17 | Release date: | 2022-07-27 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.93 Å) | Cite: | Structure of dynein-dynactin on microtubules shows tandem adaptor binding. Nature, 610, 2022
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8DYV
| Structure of human cytoplasmic dynein-1 bound to one Lis1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ... | Authors: | Reimer, J.M, DeSantis, M, Reck-Peterson, S.L, Leschziner, A.E. | Deposit date: | 2022-08-05 | Release date: | 2023-02-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.97 Å) | Cite: | Structures of human dynein in complex with the lissencephaly 1 protein, LIS1. Elife, 12, 2023
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8DYU
| Structure of human cytoplasmic dynein-1 bound to two Lis1 proteins | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ... | Authors: | Reimer, J.M, DeSantis, M, Reck-Peterson, S.L, Leschziner, A.E. | Deposit date: | 2022-08-05 | Release date: | 2023-02-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structures of human dynein in complex with the lissencephaly 1 protein, LIS1. Elife, 12, 2023
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8RGG
| Structure of dynein-2 intermediate chain DYNC2I2 (WDR34) in complex with dynein-2 heavy chain DYNC2H1. | Descriptor: | Cytoplasmic dynein 2 intermediate chain 1, Cytoplasmic dynein 2 intermediate chain 2, Dynein light chain 1, ... | Authors: | Mukhopadhyay, A.G, Toropova, K, Daly, L, Wells, J, Vuolo, L, Mladenov, M, Seda, M, Jenkins, D, Stephens, D.J, Roberts, A.J. | Deposit date: | 2023-12-13 | Release date: | 2024-03-20 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure and tethering mechanism of dynein-2 intermediate chains in intraflagellar transport. Embo J., 43, 2024
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8PQV
| Cytoplasmic dynein-1 motor domain in post-powerstroke state | Descriptor: | Cytoplasmic dynein 1 heavy chain 1 | Authors: | Singh, K, Lau, C.K, Manigrasso, G, Gassmann, R, Carter, A.P. | Deposit date: | 2023-07-12 | Release date: | 2024-03-27 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Molecular mechanism of dynein-dynactin complex assembly by LIS1. Science, 383, 2024
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7KZN
| Outer dynein arm core subcomplex from C. reinhardtii | Descriptor: | DC1, DC2, Dynein 11 kDa light chain, ... | Authors: | Walton, T, Wu, H, Brown, A.B. | Deposit date: | 2020-12-10 | Release date: | 2021-01-20 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure of a microtubule-bound axonemal dynein. Nat Commun, 12, 2021
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8DZZ
| Cryo-EM structure of chi dynein bound to Lis1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ... | Authors: | Reimer, J.M, Lahiri, I, Leschziner, A.E. | Deposit date: | 2022-08-08 | Release date: | 2023-08-30 | Last modified: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge. Nat.Struct.Mol.Biol., 30, 2023
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8J07
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8PQW
| Cytoplasmic dynein-1 motor domain bound to dynactin-p150glued and LIS1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ... | Authors: | Singh, K, Lau, C.K, Manigrasso, G, Gassmann, R, Carter, A.P. | Deposit date: | 2023-07-12 | Release date: | 2024-03-27 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Molecular mechanism of dynein-dynactin complex assembly by LIS1. Science, 383, 2024
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6ZYX
| Outer Dynein Arm-Shulin complex - Shulin region from Tetrahymena thermophila | Descriptor: | Dynein heavy chain, outer arm protein, Dynein intermediate chain 2, ... | Authors: | Mali, G.R, Abid Ali, F, Lau, C.K, Carter, A.P. | Deposit date: | 2020-08-03 | Release date: | 2021-01-20 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Shulin packages axonemal outer dynein arms for ciliary targeting. Science, 371, 2021
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7Z8K
| Cytoplasmic dynein (A1) bound to BICDR1 | Descriptor: | ARP1 actin related protein 1 homolog A, BICD family-like cargo adapter 1, Cytoplasmic dynein 1 heavy chain 1, ... | Authors: | Chaaban, S, Carter, A.P. | Deposit date: | 2022-03-17 | Release date: | 2022-07-27 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (4.37 Å) | Cite: | Structure of dynein-dynactin on microtubules shows tandem adaptor binding. Nature, 610, 2022
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6ZYY
| Outer Dynein Arm-Shulin complex - Dyh3 motor region (Tetrahymena thermophila) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ... | Authors: | Mali, G.R, Abid Ali, F, Lau, C.K, Begum, F, Boulanger, J, Howe, J.D, Chen, Z.A, Rappsilber, J, Skehel, M, Carter, A.P. | Deposit date: | 2020-08-03 | Release date: | 2021-02-03 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Shulin packages axonemal outer dynein arms for ciliary targeting. Science, 371, 2021
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7MI1
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6RLB
| Structure of the dynein-2 complex; tail domain | Descriptor: | Cytoplasmic dynein 2 light intermediate chain 1, Dynein light chain 1, cytoplasmic, ... | Authors: | Toropova, K, Zalyte, R, Mukhopadhyay, A.G, Mladenov, M, Carter, A.P, Roberts, A.J. | Deposit date: | 2019-05-01 | Release date: | 2019-08-28 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structure of the dynein-2 complex and its assembly with intraflagellar transport trains. Nat.Struct.Mol.Biol., 26, 2019
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7K5B
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7Z8L
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8PQZ
| Cytoplasmic dynein-1 A1/A2 motor domains bound to LIS1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1, ... | Authors: | Singh, K, Lau, C.K, Manigrasso, G, Gassmann, R, Carter, A.P. | Deposit date: | 2023-07-12 | Release date: | 2024-03-27 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (5.5 Å) | Cite: | Molecular mechanism of dynein-dynactin complex assembly by LIS1. Science, 383, 2024
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3QMZ
| Crystal structure of the cytoplasmic dynein heavy chain motor domain | Descriptor: | Cytoplasmic dynein heavy chain, Glutathione-S-transferase | Authors: | Cho, C, Carter, A.P, Jin, L, Vale, R.D. | Deposit date: | 2011-02-07 | Release date: | 2011-03-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (6 Å) | Cite: | Crystal structure of the dynein motor domain. Science, 331, 2011
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7KZM
| Outer dynein arm bound to doublet microtubules from C. reinhardtii | Descriptor: | DC1, DC2, Dynein 11 kDa light chain, ... | Authors: | Walton, T, Wu, H, Brown, A.B. | Deposit date: | 2020-12-10 | Release date: | 2021-01-20 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (7.5 Å) | Cite: | Structure of a microtubule-bound axonemal dynein. Nat Commun, 12, 2021
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5VH9
| Cryo-EM structure of yeast cytoplasmic dynein-1 with Lis1 and ATP | Descriptor: | Dynein heavy chain, cytoplasmic, Nuclear distribution protein PAC1 | Authors: | Cianfrocco, M.A, DeSantis, M.E, Htet, Z.M, Tran, P.T, Reck-Peterson, S.L, Leschziner, A.E. | Deposit date: | 2017-04-12 | Release date: | 2017-09-06 | Last modified: | 2020-01-01 | Method: | ELECTRON MICROSCOPY (7.7 Å) | Cite: | Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. Cell, 170, 2017
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