PDB: 340 件ウェブページステータス検索Chemie searchBIRD

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7TZO	The apo structure of human mTORC2 complex 分子名称: Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... 著者 Yu, Z, Chen, J, Pearce, D. 登録日 2022-02-16 公開日 2023-01-11 実験手法 ELECTRON MICROSCOPY (3.28 Å) 主引用文献 Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt. J.Biol.Chem., 298, 2022
5WBU	Crystal structure of mTOR(deltaN)-mLST8-PRAS40(alpha-helix & beta-strand) complex 分子名称: Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P, Yang, H. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.42 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBY	Crystal structure of mTOR(deltaN)-mLST8-PRAS40(beta-strand) complex 分子名称: Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P, Yang, H. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBH	Structure of the FRB domain of mTOR bound to a substrate recruitment peptide of S6K1 分子名称: Ribosomal protein S6 kinase beta-1, Serine/threonine-protein kinase mTOR 著者 Pavletich, N.P, Yang, H. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
8PPZ	Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR 分子名称: (1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-[(~{E})-2-(2-chlorophenyl)ethenyl]-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one, ACETATE ION, CALCIUM ION, ... 著者 Meyners, C, Deutscher, R.C.E, Hausch, F. 登録日 2023-07-10 公開日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Co-crystal structure of FKBP12, compound 7 and the FRB fragment of mTOR Chemrxiv, 2023
6EHR	The crystal structure of the human LAMTOR-RagA CTD-RagC CTD complex 分子名称: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... 著者 Scheffzek, K, Naschberger, A. 登録日 2017-09-14 公開日 2017-10-04 最終更新日 2019-04-24 実験手法 X-RAY DIFFRACTION (2.898 Å) 主引用文献 Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling. Science, 358, 2017
6EHP	The crystal structure of the human LAMTOR complex 分子名称: CHLORIDE ION, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ... 著者 Scheffzek, K, Naschberger, A. 登録日 2017-09-14 公開日 2017-10-04 最終更新日 2019-09-18 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling. Science, 358, 2017
5YK5	structure of the human Lamtor4-Lamtor5 complex 分子名称: Ragulator complex protein LAMTOR4, Ragulator complex protein LAMTOR5 著者 Wu, G, Mu, Z. 登録日 2017-10-12 公開日 2018-12-12 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane Cell Discov, 3, 2017
7VKK	Crystal structure of D. melanogaster SAMTOR V66W/E67P mutant 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, S-adenosylmethionine sensor upstream of mTORC1, SULFATE ION 著者 Zhang, T, Ding, J. 登録日 2021-09-30 公開日 2022-07-20 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.55 Å) 主引用文献 Molecular mechanism of S -adenosylmethionine sensing by SAMTOR in mTORC1 signaling. Sci Adv, 8, 2022
7VKR	Crystal structure of D. melanogaster SAMTOR in complex with SAM 分子名称: CITRIC ACID, S-ADENOSYLMETHIONINE, S-adenosylmethionine sensor upstream of mTORC1 著者 Tang, X, Zhang, T, Ding, J. 登録日 2021-09-30 公開日 2022-07-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Molecular mechanism of S -adenosylmethionine sensing by SAMTOR in mTORC1 signaling. Sci Adv, 8, 2022
7VKQ	Crystal structure of D. melanogaster SAMTOR in the SAH bound form 分子名称: S-ADENOSYL-L-HOMOCYSTEINE, S-adenosylmethionine sensor upstream of mTORC1 著者 Tang, X, Zhang, T, Ding, J. 登録日 2021-09-30 公開日 2022-07-20 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.094 Å) 主引用文献 Molecular mechanism of S -adenosylmethionine sensing by SAMTOR in mTORC1 signaling. Sci Adv, 8, 2022
3JBZ	Crystal structure of mTOR docked into EM map of dimeric ATM kinase 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Serine/threonine-protein kinase mTOR, ... 著者 Lau, W.C.Y. 登録日 2015-11-03 公開日 2016-11-16 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (28 Å) 主引用文献 Structure of the human dimeric ATM kinase. Cell Cycle, 15, 2016
8FW5	Chimeric HsGATOR1-SpGtr-SpLam complex 分子名称: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ... 著者 Tettoni, S.D, Egri, S.B, Doxsey, D.D, Ouch, C, Chang, J, Song, K, Xu, C, Shen, K. 登録日 2023-01-20 公開日 2023-07-26 最終更新日 2023-09-20 実験手法 ELECTRON MICROSCOPY (3.08 Å) 主引用文献 Structure of the Schizosaccharomyces pombe Gtr-Lam complex reveals evolutionary divergence of mTORC1-dependent amino acid sensing. Structure, 31, 2023
2GAQ	NMR SOLUTION STRUCTURE OF THE FRB DOMAIN OF mTOR 分子名称: FKBP12-rapamycin complex-associated protein 著者 Leone, M, Pellecchia, M. 登録日 2006-03-09 公開日 2006-08-08 最終更新日 2022-03-09 実験手法 SOLUTION NMR 主引用文献 The FRB Domain of mTOR: NMR Solution Structure and Inhibitor Design. Biochemistry, 45, 2006
6U62	Raptor-Rag-Ragulator complex 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Rogala, K.B, Sabatini, D.M. 登録日 2019-08-29 公開日 2019-10-30 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.18 Å) 主引用文献 Structural basis for the docking of mTORC1 on the lysosomal surface. Science, 366, 2019
2NPU	The solution structure of the rapamycin-binding domain of mTOR (FRB) 分子名称: FKBP12-rapamycin complex-associated protein 著者 Veverka, V, Crabbe, T, Bird, I, Lennie, G, Muskett, F.W, Taylor, R.J, Carr, M.D. 登録日 2006-10-30 公開日 2007-09-18 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR. Oncogene, 27, 2008
2RSE	NMR structure of FKBP12-mTOR FRB domain-rapamycin complex structure determined based on PCS 分子名称: Peptidyl-prolyl cis-trans isomerase FKBP1A, Serine/threonine-protein kinase mTOR, TERBIUM(III) ION 著者 Kobashigawa, Y, Ushio, M, Saio, T, Inagaki, F. 登録日 2012-01-25 公開日 2012-05-30 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Convenient method for resolving degeneracies due to symmetry of the magnetic susceptibility tensor and its application to pseudo contact shift-based protein-protein complex structure determination. J.Biomol.Nmr, 53, 2012
3L13	Crystal Structures of Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors 分子名称: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, [3-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenyl]methanol 著者 Murray, J.M, Wiesmann, C. 登録日 2009-12-10 公開日 2010-02-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer. J.Med.Chem., 53, 2010
3L17	Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer 分子名称: 4-methyl-5-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 著者 Murray, J.M, Wiesmann, C. 登録日 2009-12-10 公開日 2010-02-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer. J.Med.Chem., 53, 2010
7PED	DEPTOR DEP domain tandem (DEPt) 分子名称: DEP domain-containing mTOR-interacting protein 著者 Waelchli, M, Jakob, R, Maier, T. 登録日 2021-08-09 公開日 2021-09-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
5GPG	Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB domain of human mTOR 分子名称: Peptidyl-prolyl cis-trans isomerase FKBP3, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, Serine/threonine-protein kinase mTOR 著者 Lee, H.B, Lee, S.Y, Rhee, H.W, Lee, C.W. 登録日 2016-08-02 公開日 2016-10-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Proximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells Acs Cent.Sci., 2, 2016
4FA6	Design and Synthesis of a Novel Pyrrolidinyl Pyrido Pyrimidinone Derivative as a Potent Inhibitor of PI3Ka and mTOR 分子名称: 2-amino-8-cyclopentyl-4-methyl-6-(1H-pyrazol-4-yl)pyrido[2,3-d]pyrimidin-7(8H)-one, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 著者 Pannifer, A, Greasley, S.E. 登録日 2012-05-21 公開日 2013-04-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kalpha and mTOR Bioorg.Med.Chem.Lett., 22, 2012
3L16	Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer 分子名称: 5-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)pyridin-2-amine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 著者 Murray, J.M, Wiesmann, C. 登録日 2009-12-10 公開日 2010-02-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer. J.Med.Chem., 53, 2010
5OQ4	PQR309 - a Potent, Brain-Penetrant, Orally Bioavailable, pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology 分子名称: 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION 著者 Williams, R.L, Zhang, X. 登録日 2017-08-10 公開日 2017-09-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology. J. Med. Chem., 60, 2017
4DRH	Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of mTOR at low pH 分子名称: Peptidyl-prolyl cis-trans isomerase FKBP5, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, SULFATE ION, ... 著者 Maerz, A.M, Bracher, A, Hausch, F. 登録日 2012-02-17 公開日 2013-02-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin. Mol.Cell.Biol., 33, 2013

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