3L13
Crystal Structures of Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors
Summary for 3L13
Entry DOI | 10.2210/pdb3l13/pdb |
Related | 3L16 3L17 |
Descriptor | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, [3-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenyl]methanol (2 entities in total) |
Functional Keywords | kinase, atp-binding, nucleotide-binding, transferase, pi3k-gamma p110 gamma |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P48736 |
Total number of polymer chains | 1 |
Total formula weight | 110401.84 |
Authors | Murray, J.M.,Wiesmann, C. (deposition date: 2009-12-10, release date: 2010-02-16, Last modification date: 2023-09-06) |
Primary citation | Sutherlin, D.P.,Sampath, D.,Berry, M.,Castanedo, G.,Chang, Z.,Chuckowree, I.,Dotson, J.,Folkes, A.,Friedman, L.,Goldsmith, R.,Heffron, T.,Lee, L.,Lesnick, J.,Lewis, C.,Mathieu, S.,Nonomiya, J.,Olivero, A.,Pang, J.,Prior, W.W.,Salphati, L.,Sideris, S.,Tian, Q.,Tsui, V.,Wan, N.C.,Wang, S.,Wiesmann, C.,Wong, S.,Zhu, B.Y. Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer. J.Med.Chem., 53:1086-1097, 2010 Cited by PubMed: 20050669DOI: 10.1021/jm901284w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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