3L13
Crystal Structures of Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | polymer | 960 | 109898.2 | 1 | UniProt (P48736) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | Homo sapiens (human) | PI3-kinase p110 subunit gamma, PtdIns-3-kinase subunit p110, PI3Kgamma, PI3K, p120-PI3K |
| 2 | A | [3-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenyl]methanol | non-polymer | 503.6 | 1 | Chemie (JZW) |
Sequence modifications
A: 144 - 1102 (UniProt: P48736)
| PDB | External Database | Details |
|---|---|---|
| Met 143 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 109898.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 503.6 | |
| All* | Total formula weight | 110401.8 |
