PDB: 10243 resultsInfo pagesStatus searchChemie searchBIRD

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1KPS	Structural Basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin conjugating enzyme Ubc9 and RanGAP1 Descriptor: Ran-GTPase activating protein 1, SULFATE ION, Ubiquitin-like protein SUMO-1 conjugating enzyme Authors: Bernier-Villamor, V, Sampson, D.A, Matunis, M.J, Lima, C.D. Deposit date: 2002-01-02 Release date: 2002-02-13 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1. Cell(Cambridge,Mass.), 108, 2002
5XPU	Crystal structure of MAD2L2/REV7 in complex with a CAMP fragment in a monoclinic crystal Descriptor: Chromosome alignment-maintaining phosphoprotein 1, Mitotic spindle assembly checkpoint protein MAD2B Authors: Hara, K, Taharazako, S, Hashimoto, H. Deposit date: 2017-06-05 Release date: 2017-09-20 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.304 Å) Cite: Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP). J. Biol. Chem., 292, 2017
8BB2	Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with PEG linker (conformation #2) Descriptor: 1,2-ETHANEDIOL, Elongin-B, Elongin-C, ... Authors: Kraemer, A, Doelle, A, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2022-10-12 Release date: 2022-11-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with PEG linker (conformation #2) To Be Published
8BB3	Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with PEG linker (conformation #1) Descriptor: 1,2-ETHANEDIOL, Elongin-B, Elongin-C, ... Authors: Kraemer, A, Doelle, A, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2022-10-12 Release date: 2022-11-09 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with PEG linker (conformation #1) To Be Published
6ZH6	Cryo-EM structure of DNA-PKcs:Ku80ct194 Descriptor: DNA-dependent protein kinase catalytic subunit,DNA-PKcs, X-ray repair cross-complementing protein 5 Authors: Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. Deposit date: 2020-06-21 Release date: 2020-10-21 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.93 Å) Cite: Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021
6YUH	Crystal structure of SMYD3 with diperodon R enantiomer bound to allosteric site Descriptor: Diperodon, GLYCEROL, Histone-lysine N-methyltransferase SMYD3, ... Authors: Cederfelt, D, Talibov, V.O, Dobritzsch, D, Danielson, U.H. Deposit date: 2020-04-27 Release date: 2021-01-13 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase. Chembiochem, 22, 2021
8ARI	Cryo-EM structure of human CtBP1/RAI2(303-362) delta(331-341) filament Descriptor: C-terminal-binding protein 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Retinoic acid-induced protein 2 Authors: Mullapudi, E, Goradia, N, Wilmanns, M. Deposit date: 2022-08-16 Release date: 2023-08-23 Method: ELECTRON MICROSCOPY (3 Å) Cite: Cryo-EM structure of human CtBP1/RAI2(303-362) delta(331-341) filament To Be Published
6ZFP	Cryo-EM structure of DNA-PKcs (State 2) Descriptor: DNA-dependent protein kinase catalytic subunit,DNA-PKcs,DNA-PKcs Authors: Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. Deposit date: 2020-06-17 Release date: 2020-10-21 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.24 Å) Cite: Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021
6ZH2	Cryo-EM structure of DNA-PKcs (State 1) Descriptor: DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs Authors: Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. Deposit date: 2020-06-20 Release date: 2020-10-21 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.92 Å) Cite: Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021
6ZH4	Cryo-EM structure of DNA-PKcs (State 3) Descriptor: DNA-dependent protein kinase catalytic subunit,DNA-PKcs Authors: Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. Deposit date: 2020-06-20 Release date: 2020-10-21 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.62 Å) Cite: Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021
3S7F	Structural Basis of Substrate Methylation and Inhibition of SMYD2 Descriptor: (R,R)-2,3-BUTANEDIOL, N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ... Authors: Ferguson, A.D. Deposit date: 2011-05-26 Release date: 2011-08-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structural Basis of Substrate Methylation and Inhibition of SMYD2. Structure, 19, 2011
3SAY	Crystal structure of human glycogen synthase kinase 3 beta (GSK3b) in complex with inhibitor 142 Descriptor: (3Z)-N,N-diethyl-3-[(3E)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide, (4S)-2-METHYL-2,4-PENTANEDIOL, FORMIC ACID, ... Authors: Mazanetz, M.P, Cheng, R.K.Y, Rowan, F, Laughton, C.A, Barker, J.J, Fischer, P.M. Deposit date: 2011-06-03 Release date: 2012-06-13 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.231 Å) Cite: Crystal structure of human glycogen synthase kinase 3 beta (GSK3b) in complex with inhibitor 142 To be Published
3S7D	Structural Basis of Substrate Methylation and Inhibition of SMYD2 Descriptor: (R,R)-2,3-BUTANEDIOL, Monomethylated p53 peptide, N-lysine methyltransferase SMYD2, ... Authors: Ferguson, A.D. Deposit date: 2011-05-26 Release date: 2011-08-10 Last modified: 2025-03-26 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Basis of Substrate Methylation and Inhibition of SMYD2. Structure, 19, 2011
3S7B	Structural Basis of Substrate Methylation and Inhibition of SMYD2 Descriptor: (R,R)-2,3-BUTANEDIOL, N-cyclohexyl-N~3~-[2-(3,4-dichlorophenyl)ethyl]-N-(2-{[2-(5-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino}ethyl)-beta-alaninamide, N-lysine methyltransferase SMYD2, ... Authors: Ferguson, A.D. Deposit date: 2011-05-26 Release date: 2011-08-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Structural Basis of Substrate Methylation and Inhibition of SMYD2. Structure, 19, 2011
3S7J	Structural Basis of Substrate Methylation and Inhibition of SMYD2 Descriptor: N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ZINC ION Authors: Ferguson, A.D. Deposit date: 2011-05-26 Release date: 2011-08-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.04 Å) Cite: Structural Basis of Substrate Methylation and Inhibition of SMYD2. Structure, 19, 2011
9LNR	Crystal structure of SKLB-D18 with ERK2 Descriptor: 4-[5-chloranyl-2-[[3-[(dimethylamino)methyl]phenyl]amino]pyrimidin-4-yl]-~{N}-morpholin-4-yl-thiophene-2-carboxamide, GLYCEROL, Mitogen-activated protein kinase 1 Authors: Xiao, H, Sun, Q. Deposit date: 2025-01-21 Release date: 2025-04-02 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A first-in-class selective inhibitor of ERK1/2 and ERK5 overcomes drug resistance with a single-molecule strategy. Signal Transduct Target Ther, 10, 2025
6T7D	Structure of human Sox11 transcription factor in complex with a nucleosome Descriptor: DNA (151-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... Authors: Dodonova, S.O, Zhu, F, Dienemann, C, Taipale, J, Cramer, P. Deposit date: 2019-10-21 Release date: 2020-04-29 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function. Nature, 580, 2020
1TR4	Solution structure of human oncogenic protein gankyrin Descriptor: 26S proteasome non-ATPase regulatory subunit 10 Authors: Yuan, C, Li, J, Mahajan, A, Poi, M.J, Byeon, I.J, Tsai, M.D. Deposit date: 2004-06-19 Release date: 2004-11-16 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution structure of the human oncogenic protein gankyrin containing seven ankyrin repeats and analysis of its structure--function relationship. Biochemistry, 43, 2004
6T7C	Structure of two copies of human Sox11 transcription factor in complex with a nucleosome Descriptor: DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... Authors: Dodonova, S.O, Zhu, F, Dienemann, C, Taipale, J, Cramer, P. Deposit date: 2019-10-21 Release date: 2020-04-29 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (4 Å) Cite: Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function. Nature, 580, 2020
9LAF	Crystal structure of Elongin BC-EPOP peptide Descriptor: Elongin BC and Polycomb repressive complex 2-associated protein, Elongin-B, Elongin-C Authors: Kim, S, Lee, B.I. Deposit date: 2025-01-02 Release date: 2025-05-21 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Structural analysis of EPOP BC-box binding to the elongin BC complex. Biochem.Biophys.Res.Commun., 759, 2025
2HZ9	Crystal structure of Lys12Val/Asn95Val/Cys117Val mutant of human acidic fibroblast growth factor at 1.70 angstrom resolution. Descriptor: FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION Authors: Dubey, V.K, Lee, J, Somasundaram, T, Blaber, M. Deposit date: 2006-08-08 Release date: 2007-06-19 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Spackling the Crack: Stabilizing Human Fibroblast Growth Factor-1 by Targeting the N and C terminus beta-Strand Interactions J.Mol.Biol., 371, 2007
9QE5	VCB in complex with VHL-binding compound 82 Descriptor: (2~{S},4~{R})-1-[(2~{S})-1-(1-fluoranylcyclopropyl)carbonylpiperidin-2-yl]carbonyl-~{N}-[(1~{S})-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... Authors: Braun, M.B, Dierlamm, N, Hartmann, M.D. Deposit date: 2025-03-07 Release date: 2025-04-23 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Breaking Barriers in PROTAC Design: Improving Solubility of USP7-Targeting Degraders To Be Published
9QE4	VCB in complex with VHL-binding compound 114 Descriptor: (2~{S},4~{R})-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-~{N}-[(1~{S})-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... Authors: Braun, M.B, Dierlamm, N, Hartmann, M.D. Deposit date: 2025-03-07 Release date: 2025-04-23 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Breaking Barriers in PROTAC Design: Improving Solubility of USP7-Targeting Degraders To Be Published
7XZZ	Cryo-EM structure of the nucleosome in complex with p53 Descriptor: Cellular tumor antigen p53, DNA (169-MER), Histone H2A type 1-B/E, ... Authors: Nishimura, M, Nozawa, K, Takizawa, Y, Kurumizaka, H. Deposit date: 2022-06-03 Release date: 2022-10-12 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (4.07 Å) Cite: Structural basis for p53 binding to its nucleosomal target DNA sequence. Pnas Nexus, 1, 2022
5JWL	Factor Inhibiting HIF D201E in Complex with Zn, and Alpha-Ketoglutarate Descriptor: 2-OXOGLUTARIC ACID, DI(HYDROXYETHYL)ETHER, Hypoxia-inducible factor 1-alpha inhibitor, ... Authors: Taabazuing, C.Y, Garman, S.C, Eron, S, Knapp, M.J. Deposit date: 2016-05-12 Release date: 2017-05-17 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Factor Inhibiting HIF D201E in Complex with Zn, and Alpha-Ketoglutarate To Be Published

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