9QE4

VCB in complex with VHL-binding compound 114

This is a non-PDB format compatible entry.

Summary for 9QE4

• Entry DOI: 10.2210/pdb9qe4/pdb
• Related: 9QE5
• Descriptor: Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (4 entities in total)
• Functional Keywords: protac, degrader, complex, e3 ligase, vhl, vcb, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 198563.52

Authors

Braun, M.B.,Dierlamm, N.,Hartmann, M.D. (deposition date: 2025-03-07, release date: 2025-04-23)

• Primary citation: Wittenburg, S.,Zuleeg, M.R.,Peter, K.,Lemnitzer, P.,Voget, R.,Bricelj, A.,Gobec, M.,Dierlamm, N.,Braun, M.B.,Geiger, T.M.,Heim, C.,Stakemeier, A.,Wagner, K.G.,Nowak, R.P.,Hartmann, M.D.,Sosic, I.,Guetschow, M.,Kroenke, J.,Steinebach, C.; Breaking Barriers in PROTAC Design: Improving Solubility of USP7-Targeting Degraders; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.28 Å)