3SAY

Crystal structure of human glycogen synthase kinase 3 beta (GSK3b) in complex with inhibitor 142

Summary for 3SAY

• Entry DOI: 10.2210/pdb3say/pdb
• Descriptor: Glycogen synthase kinase-3 beta, (3Z)-N,N-diethyl-3-[(3E)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide, MALONIC ACID, ... (6 entities in total)
• Functional Keywords: kinase, atp hydrolysis, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P49841
• Total number of polymer chains: 2
• Total formula weight: 97654.49

Authors

Mazanetz, M.P.,Cheng, R.K.Y.,Rowan, F.,Laughton, C.A.,Barker, J.J.,Fischer, P.M. (deposition date: 2011-06-03, release date: 2012-06-13, Last modification date: 2023-12-06)

• Primary citation: Cheng, R.K.Y.,Rowan, F.,Barker, J.J.; Crystal structure of human glycogen synthase kinase 3 beta (GSK3b) in complex with inhibitor 142; To be Published,

Experimental method

X-RAY DIFFRACTION (2.231 Å)