3EKS
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![BU of 3eks by Molmil](/molmil-images/mine/3eks) | Crystal Structure of Monomeric Actin bound to Cytochalasin D | Descriptor: | (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylidene-1,11-dioxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate, ADENOSINE-5'-TRIPHOSPHATE, Actin-5C, ... | Authors: | Nair, U.B, Joel, P.B, Wan, Q, Lowey, S, Rould, M.A, Trybus, K.M. | Deposit date: | 2008-09-19 | Release date: | 2008-10-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of monomeric actin bound to cytochalasin D. J.Mol.Biol., 384, 2008
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3ELA
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![BU of 3ela by Molmil](/molmil-images/mine/3ela) | Crystal structure of active site inhibited coagulation factor VIIA mutant in complex with soluble tissue factor | Descriptor: | CALCIUM ION, Coagulation factor VIIA heavy chain, Coagulation factor VIIA light chain, ... | Authors: | Bjelke, J.R, Fodje, M, Svensson, L.A. | Deposit date: | 2008-09-21 | Release date: | 2008-11-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mechanism of the Ca2+-induced enhancement of the intrinsic factor VIIa activity J.Biol.Chem., 283, 2008
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5KQR
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![BU of 5kqr by Molmil](/molmil-images/mine/5kqr) | Structure of NS5 methyltransferase from Zika virus bound to S-adenosylmethionine | Descriptor: | CHLORIDE ION, Methyltransferase, PHOSPHATE ION, ... | Authors: | Jain, R, Coloma, J, Rajashankar, K.R, Aggarwal, A.K. | Deposit date: | 2016-07-06 | Release date: | 2016-09-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.331 Å) | Cite: | Structures of NS5 Methyltransferase from Zika Virus. Cell Rep, 16, 2016
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5KOY
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![BU of 5koy by Molmil](/molmil-images/mine/5koy) | Mouse pgp 34 linker deleted bound with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Multidrug resistance protein 1A | Authors: | Xia, D, Esser, L, Zhou, F. | Deposit date: | 2016-07-01 | Release date: | 2016-12-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.85 Å) | Cite: | Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. J. Biol. Chem., 292, 2017
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5KPX
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![BU of 5kpx by Molmil](/molmil-images/mine/5kpx) | Structure of RelA bound to ribosome in presence of A/R tRNA (Structure IV) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Loveland, A.B, Bah, E, Madireddy, R, Zhang, Y, Brilot, A.F, Grigorieff, N, Korostelev, A.A. | Deposit date: | 2016-07-05 | Release date: | 2016-09-28 | Last modified: | 2019-11-20 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Ribosome•RelA structures reveal the mechanism of stringent response activation. Elife, 5, 2016
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5KJ2
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![BU of 5kj2 by Molmil](/molmil-images/mine/5kj2) | The novel p300/CBP inhibitor A-485 uncovers a unique mechanism of action to target AR in castrate resistant prostate cancer | Descriptor: | Histone acetyltransferase p300, N-[(4-fluorophenyl)methyl]-2-{(1R)-5-[(methylcarbamoyl)amino]-2',4'-dioxo-2,3-dihydro-3'H-spiro[indene-1,5'-[1,3]oxazolidin]-3'-yl}-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide, SODIUM ION | Authors: | Jakob, C.G, Qiu, W, Edalji, R.P, Sun, C. | Deposit date: | 2016-06-17 | Release date: | 2017-09-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. Nature, 550, 2017
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5KLV
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![BU of 5klv by Molmil](/molmil-images/mine/5klv) | Structure of bos taurus cytochrome bc1 with fenamidone inhibited | Descriptor: | (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradecanoyloxy)propyl octadecanoate, (5S)-5-methyl-2-(methylsulfanyl)-5-phenyl-3-(phenylamino)-3,5-dihydro-4H-imidazol-4-one, 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, ... | Authors: | Xia, D, Esser, L, Zhou, F, Zhou, Y, Xiao, Y, Tang, W.K, Yu, C.A, Qin, Z. | Deposit date: | 2016-06-25 | Release date: | 2016-10-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.652 Å) | Cite: | Hydrogen Bonding to the Substrate Is Not Required for Rieske Iron-Sulfur Protein Docking to the Quinol Oxidation Site of Complex III. J.Biol.Chem., 291, 2016
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3EVJ
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![BU of 3evj by Molmil](/molmil-images/mine/3evj) | Intermediate structure of antithrombin bound to the natural pentasaccharide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranoside, ... | Authors: | Huntington, J.A, Belzar, K.J. | Deposit date: | 2008-10-13 | Release date: | 2008-10-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The critical role of hinge-region expulsion in the induced-fit heparin binding mechanism of antithrombin. J. Mol. Biol., 386, 2009
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5KPD
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![BU of 5kpd by Molmil](/molmil-images/mine/5kpd) | Mouse pgp 34 linker deleted double EQ mutant | Descriptor: | Multidrug resistance protein 1A | Authors: | Xia, D, Esser, L, Zhou, F. | Deposit date: | 2016-07-03 | Release date: | 2016-11-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. J. Biol. Chem., 292, 2017
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3EQM
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![BU of 3eqm by Molmil](/molmil-images/mine/3eqm) | |
5KKN
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![BU of 5kkn by Molmil](/molmil-images/mine/5kkn) | Crystal structure of human ACC2 BC domain in complex with ND-646, the primary amide of ND-630 | Descriptor: | 2-[1-[(2~{R})-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-bis(oxidanylidene)thieno[2,3-d]pyrimidin-3-yl]-2-methyl-propanamide, Acetyl-CoA carboxylase 2 | Authors: | Wang, R, Paul, D, Tong, L. | Deposit date: | 2016-06-22 | Release date: | 2016-07-13 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc.Natl.Acad.Sci.USA, 113, 2016
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5KN9
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![BU of 5kn9 by Molmil](/molmil-images/mine/5kn9) | MutY N-terminal domain in complex with DNA containing an intrahelical oxoG:A base-pair | Descriptor: | Adenine DNA glycosylase, CALCIUM ION, DNA (5'-D(*AP*GP*CP*AP*CP*AP*GP*GP*AP*T)-3'), ... | Authors: | Wang, L, Chakravarthy, S, Verdine, G.L. | Deposit date: | 2016-06-27 | Release date: | 2017-02-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase. J. Biol. Chem., 292, 2017
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3EVC
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![BU of 3evc by Molmil](/molmil-images/mine/3evc) | |
3ERA
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![BU of 3era by Molmil](/molmil-images/mine/3era) | RECOMBINANT ERABUTOXIN A (S8T MUTANT) | Descriptor: | ERABUTOXIN A, THIOCYANATE ION | Authors: | Gaucher, J.F, Menez, R, Arnoux, B, Menez, A, Ducruix, A. | Deposit date: | 1997-06-25 | Release date: | 1997-12-31 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | High resolution x-ray analysis of two mutants of a curaremimetic snake toxin Eur.J.Biochem., 267, 2000
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3EVA
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5KSJ
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![BU of 5ksj by Molmil](/molmil-images/mine/5ksj) | Crystal structure of deoxygenated hemoglobin in complex with Sphingosine phosphate | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | Authors: | Ahmed, M.H, Safo, M.K, Xia, Y. | Deposit date: | 2016-07-08 | Release date: | 2017-07-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease. Sci Rep, 7, 2017
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3EQA
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![BU of 3eqa by Molmil](/molmil-images/mine/3eqa) | Catalytic domain of glucoamylase from aspergillus niger complexed with tris and glycerol | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Glucoamylase, ... | Authors: | Lee, J, Paetzel, M. | Deposit date: | 2008-09-30 | Release date: | 2009-10-13 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the catalytic domain of glucoamylase from Aspergillus niger. Acta Crystallogr.,Sect.F, 67, 2011
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1BBR
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![BU of 1bbr by Molmil](/molmil-images/mine/1bbr) | |
5KPI
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![BU of 5kpi by Molmil](/molmil-images/mine/5kpi) | Mouse native PGP | Descriptor: | Multidrug resistance protein 1A | Authors: | Xia, D, Esser, L, Zhou, F. | Deposit date: | 2016-07-04 | Release date: | 2016-11-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (4.01 Å) | Cite: | Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. J. Biol. Chem., 292, 2017
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3EVB
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3EVD
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![BU of 3evd by Molmil](/molmil-images/mine/3evd) | |
3EVG
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![BU of 3evg by Molmil](/molmil-images/mine/3evg) | |
3EW3
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![BU of 3ew3 by Molmil](/molmil-images/mine/3ew3) | the 1:2 complex between a Nterminal elongated prolactin and the extra cellular domain of the rat prolactin receptor | Descriptor: | Prolactin, Prolactin receptor | Authors: | Broutin, I, Jomain, J.B, England, P, Goffin, V. | Deposit date: | 2008-10-14 | Release date: | 2009-11-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2. J.Biol.Chem., 285, 2010
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1CMU
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![BU of 1cmu by Molmil](/molmil-images/mine/1cmu) | THE ROLE OF ASPARTATE-235 IN THE BINDING OF CATIONS TO AN ARTIFICIAL CAVITY AT THE RADICAL SITE OF CYTOCHROME C PEROXIDASE | Descriptor: | CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Fitzgerald, M.M, Trester, M.L, Jensen, G.M, Mcree, D.E, Goodin, D.B. | Deposit date: | 1995-04-10 | Release date: | 1995-07-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The role of aspartate-235 in the binding of cations to an artificial cavity at the radical site of cytochrome c peroxidase. Protein Sci., 4, 1995
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2M2C
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![BU of 2m2c by Molmil](/molmil-images/mine/2m2c) | Solution structure of Duplex DNA | Descriptor: | DNA (5'-D(*CP*GP*CP*GP*TP*AP*GP*CP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(*GP*CP*GP*CP*AP*TP*GP*CP*TP*AP*CP*GP*CP*G)-3') | Authors: | Ghosh, A, Kar, R.K, Chatterjee, S, Bhunia, A. | Deposit date: | 2012-12-18 | Release date: | 2013-01-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Indolicidin targets duplex DNA: structural and mechanistic insight through a combination of spectroscopy and microscopy. Chemmedchem, 9, 2014
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