3EVJ

Intermediate structure of antithrombin bound to the natural pentasaccharide

Summary for 3EVJ

• Entry DOI: 10.2210/pdb3evj/pdb
• Related: 1NQ9 2B5T
• Related PRD ID: PRD_900028
• Descriptor: Antithrombin-III, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: serpin, heparin, blood coagulation, disease mutation, glycoprotein, heparin-binding, protease inhibitor, secreted, serine protease inhibitor, thrombophilia, hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Secreted, extracellular space: P01008
• Total number of polymer chains: 2
• Total formula weight: 104007.14

Authors

Huntington, J.A.,Belzar, K.J. (deposition date: 2008-10-13, release date: 2008-10-21, Last modification date: 2023-09-06)

• Primary citation: Langdown, J.,Belzar, K.J.,Savory, W.J.,Baglin, T.P.,Huntington, J.A.; The critical role of hinge-region expulsion in the induced-fit heparin binding mechanism of antithrombin.; J. Mol. Biol., 386:1278-1289, 2009; PubMed: 19452598

Experimental method

X-RAY DIFFRACTION (3 Å)