5KKN

Crystal structure of human ACC2 BC domain in complex with ND-646, the primary amide of ND-630

Summary for 5KKN

Entry DOI	10.2210/pdb5kkn/pdb
Descriptor	Acetyl-CoA carboxylase 2, 2-[1-[(2~{R})-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-bis(oxidanylidene)thieno[2,3-d]pyrimidin-3-yl]-2-methyl-propanamide (3 entities in total)
Functional Keywords	biotin-dependent carboxylase, grasp fold, lyase
Biological source	Homo sapiens (Human)
Cellular location	Mitochondrion : O00763
Total number of polymer chains	2
Total formula weight	121323.18
Authors	Wang, R.,Paul, D.,Tong, L. (deposition date: 2016-06-22, release date: 2016-07-13, Last modification date: 2024-03-06)
Primary citation	Harriman, G.,Greenwood, J.,Bhat, S.,Huang, X.,Wang, R.,Paul, D.,Tong, L.,Saha, A.K.,Westlin, W.F.,Kapeller, R.,Harwood, H.J. Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc.Natl.Acad.Sci.USA, 113:E1796-E1805, 2016 Cited by PubMed: 26976583 DOI: 10.1073/pnas.1520686113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation