5KKN
Crystal structure of human ACC2 BC domain in complex with ND-646, the primary amide of ND-630
Summary for 5KKN
Entry DOI | 10.2210/pdb5kkn/pdb |
Descriptor | Acetyl-CoA carboxylase 2, 2-[1-[(2~{R})-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-bis(oxidanylidene)thieno[2,3-d]pyrimidin-3-yl]-2-methyl-propanamide (3 entities in total) |
Functional Keywords | biotin-dependent carboxylase, grasp fold, lyase |
Biological source | Homo sapiens (Human) |
Cellular location | Mitochondrion : O00763 |
Total number of polymer chains | 2 |
Total formula weight | 121323.18 |
Authors | |
Primary citation | Harriman, G.,Greenwood, J.,Bhat, S.,Huang, X.,Wang, R.,Paul, D.,Tong, L.,Saha, A.K.,Westlin, W.F.,Kapeller, R.,Harwood, H.J. Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc.Natl.Acad.Sci.USA, 113:E1796-E1805, 2016 Cited by PubMed: 26976583DOI: 10.1073/pnas.1520686113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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