5KKN
Crystal structure of human ACC2 BC domain in complex with ND-646, the primary amide of ND-630
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, C | Acetyl-CoA carboxylase 2 | polymer | 540 | 60092.9 | 2 | UniProt (O00763) Pfam (PF00289) Pfam (PF02786) Pfam (PF02785) In PDB | Homo sapiens (Human) | ACC-beta |
2 | B, C | 2-[1-[(2~{R})-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-bis(oxidanylidene)thieno[2,3-d]pyrimidin-3-yl]-2-methyl-propanamide | non-polymer | 568.6 | 2 | Chemie (6U3) | |||
3 | water | water | 18.0 | 26 | Chemie (HOH) |
Sequence modifications
B, C: 238 - 760 (UniProt: O00763)
PDB | External Database | Details |
---|---|---|
Met 221 | - | initiating methionine |
Gly 222 | - | expression tag |
Ser 223 | - | expression tag |
Ser 224 | - | expression tag |
His 225 | - | expression tag |
His 226 | - | expression tag |
His 227 | - | expression tag |
His 228 | - | expression tag |
His 229 | - | expression tag |
His 230 | - | expression tag |
Glu 231 | - | expression tag |
Asn 232 | - | expression tag |
Leu 233 | - | expression tag |
Tyr 234 | - | expression tag |
Phe 235 | - | expression tag |
Gln 236 | - | expression tag |
Gly 237 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 120185.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1137.3 | |
All* | Total formula weight | 121323.2 |