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5D0M
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BU of 5d0m by Molmil
Structure of UbE2D2:RNF165:Ub complex
Descriptor: PHOSPHATE ION, Polyubiquitin-B, RING finger protein 165, ...
Authors:Wright, J.D, Day, C.L, Mace, P.D.
Deposit date:2015-08-03
Release date:2015-12-09
Last modified:2016-01-20
Method:X-RAY DIFFRACTION (1.913 Å)
Cite:Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity.
Nat.Struct.Mol.Biol., 23, 2016
8J1R
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BU of 8j1r by Molmil
cryo-EM structures of Ufd4 in complex with Ubc4-Ub
Descriptor: Ubiquitin fusion degradation protein 4, Ubiquitin-conjugating enzyme E2 4
Authors:Ai, H.S, Mao, J.X, Wu, X.W, Cai, H.Y, Pan, M, Liu, L.
Deposit date:2023-04-13
Release date:2024-04-17
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Structural Visualization of HECT-E3 Ufd4 accepting and transferring Ubiquitin to Form K29/K48-branched Polyubiquitination on N-degron. bioRxiv,doi: ttps://doi.org/10.1101/2023.05.23.542033
To Be Published
5D1M
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BU of 5d1m by Molmil
Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7 (P199A)
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase RNF25, ...
Authors:Liang, Y.-H, Li, S, Weissman, A.M, Ji, X.
Deposit date:2015-08-04
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.581 Å)
Cite:Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B.
J.Biol.Chem., 290, 2015
8ODR
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BU of 8odr by Molmil
Mimetic of UBC9-SUMO1
Descriptor: SULFATE ION, SUMO-conjugating enzyme UBC9, Small ubiquitin-related modifier 1
Authors:Coste, F, Goffinont, S, Suskiewicz, M.J.
Deposit date:2023-03-09
Release date:2023-06-07
Last modified:2023-07-19
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural insights into the regulation of the human E2∼SUMO conjugate through analysis of its stable mimetic.
J.Biol.Chem., 299, 2023
5D2M
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BU of 5d2m by Molmil
Complex between human SUMO2-RANGAP1, UBC9 and ZNF451
Descriptor: 1,2-ETHANEDIOL, Ran GTPase-activating protein 1, SUMO-conjugating enzyme UBC9, ...
Authors:Cappadocia, L, Lima, C.D.
Deposit date:2015-08-05
Release date:2015-11-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase.
Nat.Struct.Mol.Biol., 22, 2015
5EDV
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BU of 5edv by Molmil
Structure of the HOIP-RBR/UbcH5B~ubiquitin transfer complex
Descriptor: E3 ubiquitin-protein ligase RNF31, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 D2, ...
Authors:Lechtenberg, B.C, Mace, P.D, Sanishvili, R, Riedl, S.J.
Deposit date:2015-10-22
Release date:2016-01-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.48 Å)
Cite:Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation.
Nature, 529, 2016
8OIF
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BU of 8oif by Molmil
Structure of the UBE1L activating enzyme bound to ISG15 and UBE2L6
Descriptor: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ...
Authors:Wallace, I, Kheewoong, B, Prabu, J.R, Vollrath, R, von Gronau, S, Schulman, B.A, Swatek, K.N.
Deposit date:2023-03-22
Release date:2023-12-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Insights into the ISG15 transfer cascade by the UBE1L activating enzyme.
Nat Commun, 14, 2023
5D1K
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BU of 5d1k by Molmil
Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase RNF25, ...
Authors:Liang, Y.-H, Li, S, Weissman, A.M, Ji, X.
Deposit date:2015-08-04
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B.
J.Biol.Chem., 290, 2015
8PMQ
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BU of 8pmq by Molmil
Catalytic module of yeast GID E3 ligase bound to multiphosphorylated Ubc8~ubiquitin
Descriptor: E3 ubiquitin-protein ligase RMD5, Protein FYV10, Ubiquitin, ...
Authors:Chrustowicz, J, Sherpa, D, Prabu, R.J, Schulman, B.A.
Deposit date:2023-06-29
Release date:2024-01-03
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies.
Mol.Cell, 84, 2024
8PJN
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BU of 8pjn by Molmil
Catalytic module of human CTLH E3 ligase bound to multiphosphorylated UBE2H~ubiquitin
Descriptor: E3 ubiquitin-protein transferase MAEA, E3 ubiquitin-protein transferase RMND5A, Ubiquitin, ...
Authors:Chrustowicz, J, Sherpa, D, Prabu, R.J, Schulman, B.A.
Deposit date:2023-06-23
Release date:2024-01-03
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies.
Mol.Cell, 84, 2024
8PQL
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BU of 8pql by Molmil
K48-linked ubiquitin chain formation with a cullin-RING E3 ligase and Cdc34: NEDD8-CUL2-RBX1-ELOB/C-FEM1C with trapped UBE2R2-donor UB-acceptor UB-SIL1 peptide
Descriptor: 5-azanylpentan-2-one, Cullin-2, E3 ubiquitin-protein ligase RBX1, ...
Authors:Liwocha, J, Prabu, J.R, Kleiger, G, Schulman, B.A.
Deposit date:2023-07-11
Release date:2024-02-14
Last modified:2024-04-17
Method:ELECTRON MICROSCOPY (3.76 Å)
Cite:Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases.
Nat.Struct.Mol.Biol., 31, 2024
8Q7R
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BU of 8q7r by Molmil
Ubiquitin ligation to substrate by a cullin-RING E3 ligase & Cdc34: NEDD8-CUL2-RBX1-ELOB/C-FEM1C with trapped UBE2R2~donor UB-Sil1 peptide
Descriptor: 5-azanyl-1-oxidanyl-pentan-2-one, Cullin-2, E3 ubiquitin-protein ligase RBX1, ...
Authors:Liwocha, J, Prabu, J.R, Kleiger, G, Schulman, B.A.
Deposit date:2023-08-16
Release date:2024-02-21
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (3.71 Å)
Cite:Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting.
Mol.Cell, 84, 2024
5EYA
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BU of 5eya by Molmil
TRIM25 RING domain in complex with Ubc13-Ub conjugate
Descriptor: Polyubiquitin-B, Tripartite motif-containing 25 variant, Ubiquitin-conjugating enzyme E2 N, ...
Authors:Pornillos, O, Sanchez, J.G.
Deposit date:2015-11-24
Release date:2016-08-17
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway.
Cell Rep, 16, 2016
8R5H
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BU of 8r5h by Molmil
Ubiquitin ligation to neosubstrate by a cullin-RING E3 ligase & Cdc34: NEDD8-CUL2-RBX1-ELOB/C-VHL-MZ1 with trapped UBE2R2~donor UB-BRD4 BD2
Descriptor: (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 5-azanylpentan-2-one, Bromodomain-containing protein 4, ...
Authors:Liwocha, J, Prabu, J.R, Kleiger, G, Schulman, B.A.
Deposit date:2023-11-16
Release date:2024-02-21
Last modified:2024-04-17
Method:ELECTRON MICROSCOPY (3.44 Å)
Cite:Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting.
Mol.Cell, 84, 2024
8RX0
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BU of 8rx0 by Molmil
(NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub
Descriptor: (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Cullin-2, Elongin-B, ...
Authors:Crowe, C, Nakasone, M.A.
Deposit date:2024-02-05
Release date:2024-03-06
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:(NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub
To Be Published
8TAU
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BU of 8tau by Molmil
APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G.
Deposit date:2023-06-27
Release date:2023-09-27
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Nat.Struct.Mol.Biol., 30, 2023
8TAR
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BU of 8tar by Molmil
APC/C-CDH1-UBE2C-Ubiquitin-CyclinB-NTD
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G.
Deposit date:2023-06-27
Release date:2023-09-27
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Nat.Struct.Mol.Biol., 30, 2023
8SEB
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BU of 8seb by Molmil
Cryo-EM structure of a single loaded human UBA7-UBE2L6-ISG15 adenylate complex
Descriptor: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ...
Authors:Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K.
Deposit date:2023-04-08
Release date:2023-10-11
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
8SEA
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BU of 8sea by Molmil
Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex (Form 1)
Descriptor: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ...
Authors:Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K.
Deposit date:2023-04-08
Release date:2023-10-11
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
8SE9
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BU of 8se9 by Molmil
Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex (Form 2)
Descriptor: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ...
Authors:Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K.
Deposit date:2023-04-08
Release date:2023-10-11
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
8SV8
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BU of 8sv8 by Molmil
Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex from a composite map
Descriptor: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ...
Authors:Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K.
Deposit date:2023-05-15
Release date:2023-10-11
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
1FBV
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BU of 1fbv by Molmil
STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES
Descriptor: SIGNAL TRANSDUCTION PROTEIN CBL, SULFATE ION, UBIQUITIN-CONJUGATING ENZYME E12-18 KDA UBCH7, ...
Authors:Zheng, N, Wang, P, Jeffrey, P.D, Pavletich, N.P.
Deposit date:2000-07-17
Release date:2000-08-30
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.
Cell(Cambridge,Mass.), 102, 2000
7OIK
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BU of 7oik by Molmil
Mouse RNF213:UBE2L3 transthiolation intermediate, chemically stabilized
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, E3 ubiquitin-protein ligase RNF213, MAGNESIUM ION, ...
Authors:Grabarczyk, D, Ahel, J, Clausen, T.
Deposit date:2021-05-11
Release date:2022-06-01
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP
To Be Published
6FGA
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BU of 6fga by Molmil
Crystal structure of TRIM21 E3 ligase, RING domain in complex with its cognate E2 conjugating enzyme UBE2E1
Descriptor: E3 ubiquitin-protein ligase TRIM21, GLYCEROL, Ubiquitin-conjugating enzyme E2 E1, ...
Authors:Anandapadamanaban, M, Moche, M, Sunnerhagen, M.
Deposit date:2018-01-10
Release date:2019-06-12
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2.
J.Biol.Chem., 294, 2019
5H7S
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BU of 5h7s by Molmil
Structural basis of the flanking zinc-finger motifs crucial for the E3 ligase activity of the LNX1 RING domain
Descriptor: E3 ubiquitin-protein ligase LNX, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-like 1, ...
Authors:Nayak, D, Sivaraman, J.
Deposit date:2016-11-21
Release date:2017-11-29
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.49 Å)
Cite:Structure of LNX1:Ubc13~Ubiquitin Complex Reveals the Role of Additional Motifs for the E3 Ligase Activity of LNX1.
J. Mol. Biol., 430, 2018

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