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5EYA
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BU of 5eya by Molmil
TRIM25 RING domain in complex with Ubc13-Ub conjugate
Descriptor: Polyubiquitin-B, Tripartite motif-containing 25 variant, Ubiquitin-conjugating enzyme E2 N, ...
Authors:Pornillos, O, Sanchez, J.G.
Deposit date:2015-11-24
Release date:2016-08-17
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway.
Cell Rep, 16, 2016
1YLA
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BU of 1yla by Molmil
Ubiquitin-conjugating enzyme E2-25 kDa (Huntington interacting protein 2)
Descriptor: Ubiquitin-conjugating enzyme E2-25 kDa
Authors:Choe, J, Avvakumov, G.V, Newman, E.M, Mackenzie, F, Kozieradzki, I, Bochkarev, A, Sundstrom, M, Arrowsmith, C, Edwards, A, Dhe-paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2005-01-19
Release date:2005-02-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity
J.Biol.Chem., 285, 2010
1ZGU
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BU of 1zgu by Molmil
Solution structure of the human Mms2-Ubiquitin complex
Descriptor: Ubiquitin, Ubiquitin-conjugating enzyme E2 variant 2
Authors:Lewis, M.J, Saltibus, L.F, Hau, D.D, Xiao, W, Spyracopoulos, L.
Deposit date:2005-04-22
Release date:2006-04-04
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structural Basis for Non-Covalent Interaction Between Ubiquitin and the Ubiquitin Conjugating Enzyme Variant Human MMS2.
J.Biomol.Nmr, 34, 2006
1Z5S
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BU of 1z5s by Molmil
Crystal structure of a complex between UBC9, SUMO-1, RANGAP1 and NUP358/RANBP2
Descriptor: Ran GTPase-activating protein 1, Ran-binding protein 2, Ubiquitin-conjugating enzyme E2 I, ...
Authors:Reverter, D, Lima, C.D.
Deposit date:2005-03-19
Release date:2005-06-07
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex.
Nature, 435, 2005
2EKE
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BU of 2eke by Molmil
Structure of a SUMO-binding-motif mimic bound to Smt3p-Ubc9p: conservation of a noncovalent Ubiquitin-like protein-E2 complex as a platform for selective interactions within a SUMO pathway
Descriptor: SUMO-conjugating enzyme UBC9, Ubiquitin-like protein SMT3
Authors:Duda, D.M, Schulman, B.A.
Deposit date:2007-03-23
Release date:2007-05-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a SUMO-binding-motif Mimic Bound to Smt3p-Ubc9p: Conservation of a Non-covalent Ubiquitin-like Protein-E2 Complex as a Platform for Selective Interactions within a SUMO Pathway
J.Mol.Biol., 369, 2007
2BF8
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BU of 2bf8 by Molmil
Crystal structure of SUMO modified ubiquitin conjugating enzyme E2- 25K
Descriptor: UBIQUITIN-CONJUGATING ENZYME E2-25 KDA, UBIQUITIN-LIKE PROTEIN SMT3C
Authors:Pichler, A, Knipscheer, P, Oberhofer, E, Van Dijk, W.J, Korner, R, Velgaard Olsen, J, Jentsch, S, Melchior, F, Sixma, T.K.
Deposit date:2004-12-06
Release date:2005-02-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Sumo Imodification of the Ubiquitin Conjugating Enzyme E2-25K
Nat.Struct.Mol.Biol., 12, 2005
2FUH
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BU of 2fuh by Molmil
Solution Structure of the UbcH5c/Ub Non-covalent Complex
Descriptor: Ubiquitin, Ubiquitin-conjugating enzyme E2 D3
Authors:Brzovic, P.S, Lissounov, A, Hoyt, D.W, Klevit, R.E.
Deposit date:2006-01-26
Release date:2006-03-28
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:A UbcH5/Ubiquitin Noncovalent Complex Is Required for Processive BRCA1-Directed Ubiquitination.
Mol.Cell, 21, 2006
2GRN
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BU of 2grn by Molmil
Crystal Structure of human RanGAP1-Ubc9
Descriptor: Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I
Authors:Yunus, A.A, Lima, C.D.
Deposit date:2006-04-24
Release date:2006-05-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
Nat.Struct.Mol.Biol., 13, 2006
2GMI
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BU of 2gmi by Molmil
Mms2/Ubc13~Ubiquitin
Descriptor: Ubiquitin, Ubiquitin-conjugating enzyme E2 13, Ubiquitin-conjugating enzyme variant MMS2
Authors:Wolberger, C, Eddins, M.J, Carlile, C.M, Gomez, K.G, Pickart, C.M.
Deposit date:2006-04-06
Release date:2006-09-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation.
Nat.Struct.Mol.Biol., 13, 2006
2GRO
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BU of 2gro by Molmil
Crystal Structure of human RanGAP1-Ubc9-N85Q
Descriptor: Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I
Authors:Yunus, A.A, Lima, C.D.
Deposit date:2006-04-24
Release date:2006-05-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
Nat.Struct.Mol.Biol., 13, 2006
2GRP
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BU of 2grp by Molmil
Crystal Structure of human RanGAP1-Ubc9-Y87A
Descriptor: Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I
Authors:Yunus, A.A, Lima, C.D.
Deposit date:2006-04-24
Release date:2006-05-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
Nat.Struct.Mol.Biol., 13, 2006
2GRR
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BU of 2grr by Molmil
Crystal Structure of human RanGAP1-Ubc9-D127S
Descriptor: Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I
Authors:Yunus, A.A, Lima, C.D.
Deposit date:2006-04-24
Release date:2006-05-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
Nat.Struct.Mol.Biol., 13, 2006
2GRQ
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BU of 2grq by Molmil
Crystal Structure of human RanGAP1-Ubc9-D127A
Descriptor: Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I
Authors:Yunus, A.A, Lima, C.D.
Deposit date:2006-04-24
Release date:2006-05-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
Nat.Struct.Mol.Biol., 13, 2006
2C2V
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BU of 2c2v by Molmil
Crystal structure of the CHIP-UBC13-UEV1a complex
Descriptor: STIP1 homology and U box-containing protein 1, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 1
Authors:Zhang, M, Roe, S.M, Pearl, L.H.
Deposit date:2005-09-30
Release date:2005-11-23
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.
Mol. Cell, 20, 2005
8SEB
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BU of 8seb by Molmil
Cryo-EM structure of a single loaded human UBA7-UBE2L6-ISG15 adenylate complex
Descriptor: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ...
Authors:Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K.
Deposit date:2023-04-08
Release date:2023-10-11
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
8SV8
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BU of 8sv8 by Molmil
Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex from a composite map
Descriptor: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ...
Authors:Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K.
Deposit date:2023-05-15
Release date:2023-10-11
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
8SEA
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BU of 8sea by Molmil
Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex (Form 1)
Descriptor: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ...
Authors:Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K.
Deposit date:2023-04-08
Release date:2023-10-11
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
8SE9
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BU of 8se9 by Molmil
Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex (Form 2)
Descriptor: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ...
Authors:Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K.
Deposit date:2023-04-08
Release date:2023-10-11
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer.
Nat Commun, 14, 2023
8RX0
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BU of 8rx0 by Molmil
(NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub
Descriptor: (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Cullin-2, Elongin-B, ...
Authors:Crowe, C, Nakasone, M.A.
Deposit date:2024-02-05
Release date:2024-03-06
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:(NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub
To Be Published
8TAR
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BU of 8tar by Molmil
APC/C-CDH1-UBE2C-Ubiquitin-CyclinB-NTD
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G.
Deposit date:2023-06-27
Release date:2023-09-27
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Nat.Struct.Mol.Biol., 30, 2023
8TAU
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BU of 8tau by Molmil
APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G.
Deposit date:2023-06-27
Release date:2023-09-27
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Nat.Struct.Mol.Biol., 30, 2023
5UDH
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BU of 5udh by Molmil
HHARI/ARIH1-UBCH7~Ubiquitin
Descriptor: E3 ubiquitin-protein ligase ARIH1, Ubiquitin C variant, Ubiquitin-conjugating enzyme E2 L3, ...
Authors:Miller, D.J, Schulman, B.A.
Deposit date:2016-12-27
Release date:2017-06-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Structural Studies of HHARI/UbcH7Ub Reveal Unique E2Ub Conformational Restriction by RBR RING1.
Structure, 25, 2017
7OIK
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BU of 7oik by Molmil
Mouse RNF213:UBE2L3 transthiolation intermediate, chemically stabilized
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, E3 ubiquitin-protein ligase RNF213, MAGNESIUM ION, ...
Authors:Grabarczyk, D, Ahel, J, Clausen, T.
Deposit date:2021-05-11
Release date:2022-06-01
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:E3 ubiquitin ligase RNF213 employs a non-canonical zinc finger active site and is allosterically regulated by ATP
To Be Published
5TTE
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BU of 5tte by Molmil
Crystal Structure of an RBR E3 ubiquitin ligase in complex with an E2-Ub thioester intermediate mimic
Descriptor: E3 ubiquitin-protein ligase ARIH1, Ubiquitin-conjugating enzyme E2 L3, ZINC ION, ...
Authors:Yuan, L, Lv, Z, Olsen, S.K.
Deposit date:2016-11-03
Release date:2017-08-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.501 Å)
Cite:Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI.
Nat Commun, 8, 2017
4R8P
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BU of 4r8p by Molmil
Crystal structure of the Ring1B/Bmi1/UbcH5c PRC1 ubiquitylation module bound to the nucleosome core particle
Descriptor: DNA (147-mer), E3 ubiquitin-protein ligase RING2, Ubiquitin-conjugating enzyme E2 D3, ...
Authors:McGinty, R.K, Henrici, R.C, Tan, S.
Deposit date:2014-09-02
Release date:2014-11-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.2846 Å)
Cite:Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome.
Nature, 514, 2014

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PDB entries from 2024-06-26

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