4PU6
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![BU of 4pu6 by Molmil](/molmil-images/mine/4pu6) | Crystal structure of potassium-dependent plant-type L-asparaginase from Phaseolus vulgaris in complex with K+ cations | Descriptor: | ASPARTIC ACID, L-ASPARAGINASE ALPHA SUBUNIT, L-ASPARAGINASE BETA SUBUNIT, ... | Authors: | Bejger, M, Gilski, M, Imiolczyk, B, Jaskolski, M. | Deposit date: | 2014-03-12 | Release date: | 2014-09-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Na+/K+ exchange switches the catalytic apparatus of potassium-dependent plant L-asparaginase Acta Crystallogr.,Sect.D, 70, 2014
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3GS6
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![BU of 3gs6 by Molmil](/molmil-images/mine/3gs6) | Vibrio Cholerea family 3 glycoside hydrolase (NagZ)in complex with N-butyryl-PUGNAc | Descriptor: | Beta-hexosaminidase, GLYCEROL, [[(3R,4R,5S,6R)-3-(BUTANOYLAMINO)-4,5-DIHYDROXY-6-(HYDROXYMETHYL)OXAN-2-YLIDENE]AMINO] N-PHENYLCARBAMATE | Authors: | Balcewich, M.D, Mark, B.L. | Deposit date: | 2009-03-26 | Release date: | 2009-06-30 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Insight into a strategy for attenuating AmpC-mediated beta-lactam resistance: structural basis for selective inhibition of the glycoside hydrolase NagZ. Protein Sci., 18, 2009
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2JBH
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![BU of 2jbh by Molmil](/molmil-images/mine/2jbh) | Human phosphoribosyl transferase domain containing 1 | Descriptor: | CALCIUM ION, GUANOSINE-5'-MONOPHOSPHATE, PHOSPHATE ION, ... | Authors: | Welin, M, Stenmark, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Eklund, H, Ericsson, U.B, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg Schiavone, L, Hogbom, M, Johansson, I, Karlberg, T, Kotenyova, T, Moche, M, Nilsson, M.E, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Nordlund, P. | Deposit date: | 2006-12-07 | Release date: | 2006-12-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural and Functional Studies of the Human Phosphoribosyltransferase Domain Containing Protein 1. FEBS J., 277, 2010
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6CWA
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4PSR
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![BU of 4psr by Molmil](/molmil-images/mine/4psr) | Crystal Structure of alpha-L-fucosidase from Fusarium graminearum in the open form in complex with L-fucose | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-fucosidase GH29, ... | Authors: | Cao, H, Walton, J, Brumm, P, Phillips Jr, G.N. | Deposit date: | 2014-03-07 | Release date: | 2014-03-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Structure and Substrate Specificity of a Eukaryotic Fucosidase from Fusarium graminearum. J.Biol.Chem., 289, 2014
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3GSM
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![BU of 3gsm by Molmil](/molmil-images/mine/3gsm) | Vibrio cholerae family 3 glycoside hydrolase (NagZ) bound to N-Valeryl-PUGNAc | Descriptor: | Beta-hexosaminidase, GLYCEROL, [[(3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(pentanoylamino)oxan-2-ylidene]amino] N-phenylcarbamate | Authors: | Balcewich, M.D, Mark, B.L. | Deposit date: | 2009-03-27 | Release date: | 2009-06-30 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Insight into a strategy for attenuating AmpC-mediated beta-lactam resistance: structural basis for selective inhibition of the glycoside hydrolase NagZ. Protein Sci., 18, 2009
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7YBP
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![BU of 7ybp by Molmil](/molmil-images/mine/7ybp) | Crystal structure of FGFR4(V550L) kinase domain with 10z | Descriptor: | Fibroblast growth factor receptor 4, SULFATE ION, ~{N}-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-6-bromanyl-5-(hydroxymethyl)-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide | Authors: | Chen, X.J, Lin, Q.M, Chen, Y.H. | Deposit date: | 2022-06-29 | Release date: | 2022-11-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.243 Å) | Cite: | Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors. J.Med.Chem., 65, 2022
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2V6G
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![BU of 2v6g by Molmil](/molmil-images/mine/2v6g) | Structure of Progesterone 5beta-Reductase from Digitalis Lanata in complex with NADP | Descriptor: | CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROGESTERONE 5-BETA-REDUCTASE, ... | Authors: | Thorn, A, Egerer-Sieber, C, Jaeger, C, Herl, V, Mueller-Uri, F, Kreis, W, Muller, Y.A. | Deposit date: | 2007-07-18 | Release date: | 2007-11-20 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Crystal Structure of Progesterone 5{Beta}-Reductase from Digitalis Lanata Defines a Novel Class of Short Chain Dehydrogenases/Reductases. J.Biol.Chem., 283, 2008
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3G9D
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![BU of 3g9d by Molmil](/molmil-images/mine/3g9d) | Crystal structure glycohydrolase | Descriptor: | Dinitrogenase reductase activating glucohydrolase, MAGNESIUM ION | Authors: | Li, X.-D, Winkler, F.K. | Deposit date: | 2009-02-13 | Release date: | 2009-07-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of Dinitrogenase Reductase-activating Glycohydrolase (DRAG) Reveals Conservation in the ADP-Ribosylhydrolase Fold and Specific Features in the ADP-Ribose-binding Pocket J.Mol.Biol., 390, 2009
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4PUE
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![BU of 4pue by Molmil](/molmil-images/mine/4pue) | Extracellulr Xylanase from Geobacillus stearothermophilus: E159Q mutant, with xylotetraose in active site | Descriptor: | CHLORIDE ION, Endo-1,4-beta-xylanase, ZINC ION, ... | Authors: | Dann, R.D, Solomon, H.V, Lansky, S, Ben-David, A, Lavid, N, Salama, R, Shoham, Y, Shoham, G. | Deposit date: | 2014-03-13 | Release date: | 2015-03-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Extracellulr Xylanase from Geobacillus stearothermophilus: E159Q mutant, with xylotetraose in active site. To be Published
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6CTY
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![BU of 6cty by Molmil](/molmil-images/mine/6cty) | Crystal structure of dihydroorotase pyrC from Yersinia pestis in complex with zinc and malate at 2.4 A resolution | Descriptor: | D-MALATE, Dihydroorotase, ZINC ION | Authors: | Lipowska, J, Shabalin, I.G, Winsor, J, Woinska, M, Cooper, D.R, Kwon, K, Shuvalova, L, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2018-03-23 | Release date: | 2018-04-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Pyrimidine biosynthesis in pathogens - Structures and analysis of dihydroorotases from Yersinia pestis and Vibrio cholerae. Int.J.Biol.Macromol., 136, 2019
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7YBX
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![BU of 7ybx by Molmil](/molmil-images/mine/7ybx) | Crystal structure of FGFR4(V550M) kinase domain with 10z | Descriptor: | Fibroblast growth factor receptor 4, SULFATE ION, ~{N}-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-6-bromanyl-5-(hydroxymethyl)-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide | Authors: | Chen, X.J, Lin, Q.M, Chen, Y.H. | Deposit date: | 2022-06-30 | Release date: | 2022-11-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.233 Å) | Cite: | Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors. J.Med.Chem., 65, 2022
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3GU1
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![BU of 3gu1 by Molmil](/molmil-images/mine/3gu1) | Y97W mutant in organophosphorus hydrolase from Deinococcus radiodurans | Descriptor: | COBALT (II) ION, GLYCEROL, Organophosphorus hydrolase | Authors: | Hawwa, R, Larsen, S, Ratia, K, Mesecar, A. | Deposit date: | 2009-03-28 | Release date: | 2009-06-30 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-based and random mutagenesis approaches increase the organophosphate-degrading activity of a phosphotriesterase homologue from Deinococcus radiodurans. J.Mol.Biol., 393, 2009
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5W4Z
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![BU of 5w4z by Molmil](/molmil-images/mine/5w4z) | Crystal Structure of Riboflavin Lyase (RcaE) with modified FMN and substrate Riboflavin | Descriptor: | 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-3-O-phosphono-D-ribitol, RIBOFLAVIN, Riboflavin Lyase | Authors: | Bhandari, D.M, Chakrabarty, Y, Zhao, B, Wood, J, Li, P, Begley, T.P. | Deposit date: | 2017-06-13 | Release date: | 2018-06-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Cannibalism Among the Flavins: a Novel C-N Bond Cleavage in Riboflavin Catabolism Mediated by Flavin-Generated Superoxide Radical To be Published
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4KNA
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2VE3
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![BU of 2ve3 by Molmil](/molmil-images/mine/2ve3) | Retinoic acid bound cyanobacterial CYP120A1 | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, PUTATIVE CYTOCHROME P450 120, RETINOIC ACID | Authors: | Kuhnel, K, Ke, N, Sligar, S.G, Schuler, M.A, Schlichting, I. | Deposit date: | 2007-10-15 | Release date: | 2008-04-29 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structures of Substrate-Free and Retinoic Acid-Bound Cyanobacterial Cytochrome P450 Cyp120A1. Biochemistry, 47, 2008
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4KF0
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![BU of 4kf0 by Molmil](/molmil-images/mine/4kf0) | Structure of the A82F P450 BM3 heme domain | Descriptor: | Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Leys, D. | Deposit date: | 2013-04-26 | Release date: | 2013-07-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Key Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate Bias. J.Biol.Chem., 288, 2013
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6KK7
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![BU of 6kk7 by Molmil](/molmil-images/mine/6kk7) | Structure of thermal-stabilised(M6) human GLP-1 receptor transmembrane domain | Descriptor: | Glucagon-like peptide 1 receptor,Endolysin,Glucagon-like peptide 1 receptor, N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine | Authors: | Song, G. | Deposit date: | 2019-07-23 | Release date: | 2019-11-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Mutagenesis facilitated crystallization of GLP-1R. Iucrj, 6, 2019
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3GUJ
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3GUO
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3GUW
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![BU of 3guw by Molmil](/molmil-images/mine/3guw) | Crystal Structure of the TatD-like Protein (AF1765) from Archaeoglobus fulgidus, Northeast Structural Genomics Consortium Target GR121 | Descriptor: | ZINC ION, uncharacterized protein AF_1765 | Authors: | Forouhar, F, Su, M, Seetharaman, J, Fang, F, Xiao, R, Cunningham, K, Ma, L, Zhao, L, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-03-30 | Release date: | 2009-04-07 | Last modified: | 2019-07-24 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Northeast Structural Genomics Consortium Target GR121 To be Published
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6KMD
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![BU of 6kmd by Molmil](/molmil-images/mine/6kmd) | Crystal structure of SeMet-phytochromobilin synthase from tomato in complex with biliverdin | Descriptor: | BILIVERDINE IX ALPHA, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Sugishima, M, Wada, K, Fukuyama, K. | Deposit date: | 2019-07-31 | Release date: | 2019-12-18 | Last modified: | 2020-01-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of phytochromobilin synthase in complex with biliverdin IX alpha , a key enzyme in the biosynthesis of phytochrome. J.Biol.Chem., 295, 2020
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2JKE
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![BU of 2jke by Molmil](/molmil-images/mine/2jke) | Structure of a family 97 alpha-glucosidase from Bacteroides thetaiotaomicron in complex with deoxynojirimycin | Descriptor: | 1,2-ETHANEDIOL, 1-DEOXYNOJIRIMYCIN, ALPHA-GLUCOSIDASE (ALPHA-GLUCOSIDASE SUSB), ... | Authors: | Gloster, T.M, Turkenburg, J.P, Potts, J.R, Henrissat, B, Davies, G.J. | Deposit date: | 2008-08-28 | Release date: | 2008-09-30 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Divergence of Catalytic Mechanism within a Glycosidase Family Provides Insight Into Evolution of Carbohydrate Metabolism by Human Gut Flora. Chem.Biol., 15, 2008
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5W6B
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![BU of 5w6b by Molmil](/molmil-images/mine/5w6b) | Phosphotriesterase variant S1 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase, ... | Authors: | Miton, C.M, Campbell, E.C, Jackson, C.J, Tokuriki, N. | Deposit date: | 2017-06-16 | Release date: | 2018-12-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.739 Å) | Cite: | Phosphotriesterase variant S1 To Be Published
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4KQN
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