7YBX

Crystal structure of FGFR4(V550M) kinase domain with 10z

Summary for 7YBX

• Entry DOI: 10.2210/pdb7ybx/pdb
• Descriptor: Fibroblast growth factor receptor 4, ~{N}-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-6-bromanyl-5-(hydroxymethyl)-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: kinase, inhibitor, structural protein, transferase-transferase inhibitor complex, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 35598.49

Authors

Chen, X.J.,Lin, Q.M.,Chen, Y.H. (deposition date: 2022-06-30, release date: 2022-11-16, Last modification date: 2023-11-29)

• Primary citation: Yang, F.,Chen, X.,Song, X.,Ortega, R.,Lin, X.,Deng, W.,Guo, J.,Tu, Z.,Patterson, A.V.,Smaill, J.B.,Chen, Y.,Lu, X.; Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors.; J.Med.Chem., 65:14809-14831, 2022; PubMed: 36278929; DOI: 10.1021/acs.jmedchem.2c01319

Experimental method

X-RAY DIFFRACTION (2.233 Å)