7YBX
Crystal structure of FGFR4(V550M) kinase domain with 10z
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Fibroblast growth factor receptor 4 | polymer | 309 | 34540.9 | 1 | UniProt (P22455) Pfam (PF07714) | Homo sapiens (human) | FGFR-4 |
| 2 | B (A) | ~{N}-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-6-bromanyl-5-(hydroxymethyl)-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide | non-polymer | 673.3 | 1 | Chemie (IH7) | |||
| 3 | C, D, E, F (A) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | G (A) | water | water | 18.0 | 179 | Chemie (HOH) |
Sequence modifications
A: 445 - 753 (UniProt: P22455)
| PDB | External Database | Details |
|---|---|---|
| Ala 477 | Cys 477 | conflict |
| Met 550 | Val 550 | engineered mutation |
| Glu 664 | Arg 664 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34540.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1057.6 | |
| All* | Total formula weight | 35598.5 |
