PDB: 46308 resultsInfo pagesStatus searchChemie searchBIRD

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1O9F	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex Descriptor: 14-3-3-LIKE PROTEIN C, FUSICOCCIN, PLASMA MEMBRANE H+ ATPASE Authors: Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. Deposit date: 2002-12-12 Release date: 2003-03-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
1O9D	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex Descriptor: 14-3-3-LIKE PROTEIN C, PLASMA MEMBRANE H+ ATPASE Authors: Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. Deposit date: 2002-12-12 Release date: 2003-03-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
6YO8	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 peptide Descriptor: 14-3-3 protein zeta/delta, Glucocorticoid receptor Authors: Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. Deposit date: 2020-04-14 Release date: 2021-03-24 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
6YMO	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pS617 peptide Descriptor: 14-3-3 protein zeta/delta, 2-HYDROXYBENZOIC ACID, Glucocorticoid receptor, ... Authors: Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. Deposit date: 2020-04-09 Release date: 2021-03-24 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
7QI1	Crystal structure of human 14-3-3 protein beta in complex with CFTR peptide pS753pS768 and PPI stabilizer CY007424 Descriptor: 14-3-3 protein theta, ARGININE, Cystic fibrosis transmembrane conductance regulator, ... Authors: Stevers, L.M, Ottmann, C. Deposit date: 2021-12-14 Release date: 2022-05-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR. Nat Commun, 13, 2022
5D3E	Crystal structure of human 14-3-3 gamma in complex with CFTR R-domain peptide pS768-pS795 Descriptor: 14-3-3 protein gamma, Cystic fibrosis transmembrane conductance regulator Authors: Stevers, L.M, Leysen, S.F.R, Ottmann, C. Deposit date: 2015-08-06 Release date: 2016-03-16 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
4ZDR	Crystal structure of 14-3-3[zeta]-LKB1 fusion protein Descriptor: 14-3-3 protein zeta/delta,GGSGGS linker,Serine/threonine-protein kinase STK11, GLYCEROL, PROPANE, ... Authors: Ding, S, Shi, Z.B. Deposit date: 2015-04-18 Release date: 2015-09-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.899 Å) Cite: Structure of the 14-3-3 zeta-LKB1 fusion protein provides insight into a novel ligand-binding mode of 14-3-3. Acta Crystallogr.,Sect.F, 71, 2015
1O9E	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex Descriptor: 14-3-3-LIKE PROTEIN C, CITRATE ANION, FUSICOCCIN Authors: Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. Deposit date: 2002-12-12 Release date: 2003-03-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
1O9C	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex Descriptor: 14-3-3-LIKE PROTEIN C, CHLORIDE ION, CITRATE ANION Authors: Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. Deposit date: 2002-12-12 Release date: 2003-03-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
5EXA	Small-molecule stabilization of the 14-3-3/Gab2 PPI interface Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, Fusicoccin A-THF derivative, ... Authors: Bier, D, Ottmann, C. Deposit date: 2015-11-23 Release date: 2016-05-04 Last modified: 2018-12-19 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chemmedchem, 11, 2016
5EWZ	Small-molecule stabilization of the 14-3-3/Gab2 PPI interface Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, GRB2-associated-binding protein 2 Authors: Bier, D, Ottmann, C. Deposit date: 2015-11-23 Release date: 2016-05-04 Last modified: 2018-12-19 Method: X-RAY DIFFRACTION (2.34 Å) Cite: Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chemmedchem, 11, 2016
6F09	Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide Descriptor: 14-3-3 protein zeta/delta, Ubiquitin carboxyl-terminal hydrolase 8 Authors: Centorrino, F, Ballone, A, Ottmann, C, Guo, S, Leysen, S. Deposit date: 2017-11-17 Release date: 2018-03-07 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.594 Å) Cite: Biophysical and structural insight into the USP8/14-3-3 interaction. FEBS Lett., 592, 2018
6BZD	Structure of 14-3-3 gamma R57E mutant bound to GlcNAcylated peptide Descriptor: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, GlcNAcylated peptide Authors: Schumacher, M.A. Deposit date: 2017-12-22 Release date: 2018-05-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.67 Å) Cite: Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FNC	Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, CALCIUM ION, ... Authors: Bier, D, Ottann, C. Deposit date: 2018-02-02 Release date: 2018-07-04 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry, 24, 2018
6FNB	Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, CALCIUM ION, ... Authors: Bier, D, Ottmann, C. Deposit date: 2018-02-02 Release date: 2018-07-04 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry, 24, 2018
7AZ2	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1014 Descriptor: 1-[4-methyl-2-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ... Authors: Wolter, M, Dijck, L.v, Ottmann, C. Deposit date: 2020-11-14 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.081 Å) Cite: Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7AZ1	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1013 Descriptor: 1-[4-methyl-3-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ... Authors: Wolter, M, Dijck, L.v, Ottmann, C. Deposit date: 2020-11-14 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
6FNA	Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, CALCIUM ION, ... Authors: Bier, D, Ottmann, C. Deposit date: 2018-02-02 Release date: 2018-07-04 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry, 24, 2018
8CHF	cryo-EM Structure of Craf:14-3-3:Mek1 Descriptor: 14-3-3 protein zeta isoform X1, 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, Dual specificity mitogen-activated protein kinase kinase 1, ... Authors: Dedden, D, Ulrich, G. Deposit date: 2023-02-07 Release date: 2024-02-21 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (4.25 Å) Cite: Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes. J.Mol.Biol., 436, 2024
8CPD	Cryo-EM structure of CRaf dimer with 14:3:3 Descriptor: 14-3-3 protein zeta isoform X1, RAF proto-oncogene serine/threonine-protein kinase Authors: Dedden, D, Graedler, U, Schwarz, D, Thomsen, M, Leuthner, B, Schneider, E, Nitsche, J. Deposit date: 2023-03-02 Release date: 2024-02-21 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (3.46 Å) Cite: Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes. J.Mol.Biol., 436, 2024
8QT5	Crystal structure of Arabidopsis thaliana 14-3-3 isoform lambda in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: 14-3-3-like protein G-BOX factor 14 lambda,Protein BRASSINAZOLE-RESISTANT 1, ACETATE ION Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-10-25 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
4ZQ0	crystal structure of Giardia 14-3-3 in complex with the phosphopeptide A8Ap Descriptor: 14-3-3 protein, A8Ap phosphopeptide, PHOSPHATE ION Authors: Fiorillo, A, Ilari, A. Deposit date: 2015-05-08 Release date: 2016-03-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions. J.Chem.Inf.Model., 55, 2015
3IQU	Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) Descriptor: 14-3-3 protein sigma, 6-mer from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... Authors: Ottmann, C, Weyand, M. Deposit date: 2009-08-21 Release date: 2010-09-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.05 Å) Cite: Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol.Cell.Biol., 30, 2010
2O98	Structure of the 14-3-3 / H+-ATPase plant complex Descriptor: 14-3-3-like protein C, FUSICOCCIN, Plasma membrane H+ ATPase, ... Authors: Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C. Deposit date: 2006-12-13 Release date: 2007-04-03 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy Mol.Cell, 25, 2007
3IQV	Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) and stabilisator Fusicoccin Descriptor: 14-3-3 protein sigma, 6-mer peptide from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... Authors: Ottmann, C, Weyand, M. Deposit date: 2009-08-21 Release date: 2010-09-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol.Cell.Biol., 30, 2010

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