4DX0
Structure of the 14-3-3/PMA2 complex stabilized by a pyrazole derivative
Summary for 4DX0
Entry DOI | 10.2210/pdb4dx0/pdb |
Related | 3M50 3M51 |
Descriptor | 14-3-3-like protein E, N.plumbaginifolia H+-translocating ATPase mRNA, 4-[(4R)-4-(4-nitrophenyl)-6-oxidanylidene-3-phenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-5-yl]benzoic acid (3 entities in total) |
Functional Keywords | 14-3-3 fold, pyrrolidinones, protein binding-hydrolase complex, protein binding/hydrolase |
Biological source | Nicotiana tabacum (American tobacco,tobacco) More |
Total number of polymer chains | 2 |
Total formula weight | 31522.58 |
Authors | Richter, A.,Rose, R.,Hedberg, C.,Waldmann, H.,Ottmann, C. (deposition date: 2012-02-27, release date: 2012-05-30, Last modification date: 2023-12-13) |
Primary citation | Richter, A.,Rose, R.,Hedberg, C.,Waldmann, H.,Ottmann, C. An Optimised Small-Molecule Stabiliser of the 14-3-3-PMA2 Protein-Protein Interaction. Chemistry, 18:6520-6527, 2012 Cited by PubMed: 22467351DOI: 10.1002/chem.201103761 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
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