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5GYZ
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BU of 5gyz by Molmil
luciferase AMP/7-cy-L complex
Descriptor: (4S)-2-[6-(azepan-1-yl)-1,3-benzothiazol-2-yl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid, ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ...
Authors:Su, J, Wang, F.
Deposit date:2016-09-26
Release date:2017-09-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of luciferase with AMP/7-cy-L at 2.4 Angstroms resolution
To Be Published
3GXO
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BU of 3gxo by Molmil
Structure of the Mitomycin 7-O-methyltransferase MmcR with bound Mitomycin A
Descriptor: CALCIUM ION, MmcR, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Singh, S, Chang, A, Bingman, C.A, Phillips Jr, G.N, Thorson, J.S.
Deposit date:2009-04-02
Release date:2010-04-21
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural characterization of the mitomycin 7-O-methyltransferase.
Proteins, 79, 2011
3BUS
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BU of 3bus by Molmil
Crystal Structure of RebM
Descriptor: Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:McCoy, J.G, Singh, S, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N.
Deposit date:2008-01-03
Release date:2008-03-25
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure and mechanism of the rebeccamycin sugar 4'-O-methyltransferase RebM.
J.Biol.Chem., 283, 2008
4OKO
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BU of 4oko by Molmil
Crystal structure of Francisella tularensis REP34 (Rapid Encystment Phenotype Protein 34 KDa)
Descriptor: ACETATE ION, Rapid Encystment Phenotype Protein 34 KDa, ZINC ION
Authors:Feld, G.K, Segelke, B.W, Corzett, M.H, Hunter, M.S, Frank, M, Rasley, A.
Deposit date:2014-01-22
Release date:2014-09-24
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.053 Å)
Cite:Structure and Function of REP34 Implicates Carboxypeptidase Activity in Francisella tularensis Host Cell Invasion.
J.Biol.Chem., 289, 2014
4H3Y
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BU of 4h3y by Molmil
Crystal structure of an asymmetric dimer of a tRNA (guanine-(N(1)-)-methyltransferase from Burkholderia phymatum bound to S-adenosyl homocystein in one half-site
Descriptor: CHLORIDE ION, S-ADENOSYL-L-HOMOCYSTEINE, tRNA (guanine-N(1)-)-methyltransferase
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2012-09-14
Release date:2012-10-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Combining functional and structural genomics to sample the essential Burkholderia structome.
Plos One, 8, 2013
1TW2
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BU of 1tw2 by Molmil
Crystal structure of Carminomycin-4-O-methyltransferase (DnrK) in complex with S-adenosyl-L-homocystein (SAH) and 4-methoxy-e-rhodomycin T (M-ET)
Descriptor: Carminomycin 4-O-methyltransferase, METHYL (4R)-2-ETHYL-2,5,12-TRIHYDROXY-7-METHOXY-6,11-DIOXO-4-{[2,3,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-RIBO-HEXOPYRANOSYL]OXY}-1H,2H,3H,4H,6H,11H-TETRACENE-1-CARBOXYLATE, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Jansson, A, Koskiniemi, H, Mantsala, P, Niemi, J, Schneider, G, Structural Proteomics in Europe (SPINE)
Deposit date:2004-06-30
Release date:2004-09-14
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a ternary complex of DnrK, a methyltransferase in daunorubicin biosynthesis, with bound products
J.Biol.Chem., 279, 2004
2OPS
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BU of 2ops by Molmil
Crystal Structure of Y188C Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
Descriptor: ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE, PHOSPHATE ION, Reverse transcriptase/ribonuclease H, ...
Authors:Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Short, S.A, Chan, J.H, Kleim, J, Stammers, D.K.
Deposit date:2007-01-30
Release date:2007-05-22
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases.
J.Med.Chem., 50, 2007
2OPQ
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BU of 2opq by Molmil
Crystal Structure of L100I Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
Descriptor: ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE, PHOSPHATE ION, Reverse transcriptase/ribonuclease H, ...
Authors:Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Short, S.A, Chan, J.H, Kleim, J, Stammers, D.K.
Deposit date:2007-01-30
Release date:2007-05-22
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases.
J.Med.Chem., 50, 2007
1D2C
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BU of 1d2c by Molmil
METHYLTRANSFERASE
Descriptor: PROTEIN (GLYCINE N-METHYLTRANSFERASE)
Authors:Huang, Y, Takusagawa, F.
Deposit date:1999-09-23
Release date:1999-10-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
J.Mol.Biol., 298, 2000
6ZK0
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BU of 6zk0 by Molmil
1.47A human IMPase with ebselen
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, Inositol monophosphatase 1, ...
Authors:Bax, B.D, Fenn, G.D.
Deposit date:2020-06-29
Release date:2020-09-23
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Crystallization and structure of ebselen bound to Cys141 of human inositol monophosphatase.
Acta Crystallogr.,Sect.F, 76, 2020
5GS7
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BU of 5gs7 by Molmil
Crystal structure determination of Cys2Ala mutant of Bile Salt Hydrolase from Enterococcus feacalis
Descriptor: Choloylglycine hydrolase
Authors:Ramasamy, S, Deepak, C, Varshney, N.K, Suresh, C.G.
Deposit date:2016-08-14
Release date:2017-08-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure determination of Cys2Ala mutant of Bile Salt Hydrolase from Enterococcus feacalis
To Be Published
2OPP
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BU of 2opp by Molmil
Crystal Structure of HIV-1 Reverse Transcriptase in Complex with GW420867X.
Descriptor: ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Chan, S.J.H, Kleim, J, Stammers, D.K.
Deposit date:2007-01-30
Release date:2007-05-22
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases.
J.Med.Chem., 50, 2007
3O7B
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BU of 3o7b by Molmil
Crystal structure of Archaeoglobus Fulgidus Nep1 bound to S-adenosylhomocysteine
Descriptor: Ribosome biogenesis Nep1 RNA methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, TYROSINE
Authors:Thomas, S.R, LaRonde-LeBlanc, N.
Deposit date:2010-07-30
Release date:2011-01-19
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis.
Nucleic Acids Res., 39, 2011
1NC1
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BU of 1nc1 by Molmil
Crystal structure of E. coli MTA/AdoHcy nucleosidase complexed with 5'-methylthiotubercidin (MTH)
Descriptor: 2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-METHYLSULFANYLMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, MTA/SAH nucleosidase
Authors:Lee, J.E, Cornell, K.A, Riscoe, M.K, Howell, P.L.
Deposit date:2002-12-04
Release date:2003-11-25
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysis.
J.Biol.Chem., 278, 2003
1QJE
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BU of 1qje by Molmil
Isopenicillin N synthase from Aspergillus nidulans (IP1 - Fe complex)
Descriptor: FE (II) ION, ISOPENICILLIN N, ISOPENICILLIN N SYNTHASE, ...
Authors:Burzlaff, N.I, Clifton, I.J, Rutledge, P.J, Roach, P.L, Adlington, R.M, Baldwin, J.E.
Deposit date:1999-06-23
Release date:2000-06-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:The Reaction Cycle of Isopenicillin N Synthase Observed by X-Ray Diffraction
Nature, 401, 1999
8DOM
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BU of 8dom by Molmil
Structure of the N358Y single variant ofserine hydroxymethyltransferase 8 from Glycine max cultivar Essex complexed with PLP
Descriptor: 1,2-ETHANEDIOL, Serine hydroxymethyltransferase
Authors:Korasick, D.A, Beamer, L.J.
Deposit date:2022-07-13
Release date:2023-07-19
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structural and functional analysis of two SHMT8 variants associated with soybean cyst nematode resistance.
Febs J., 291, 2024
5HU4
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BU of 5hu4 by Molmil
Cystal structure of listeria monocytogenes sortase A
Descriptor: Cysteine protease
Authors:Li, H.
Deposit date:2016-01-27
Release date:2017-02-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Inhibition of sortase A by chalcone prevents Listeria monocytogenes infection.
Biochem. Pharmacol., 106, 2016
7SU8
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BU of 7su8 by Molmil
DIHYDRONEOPTERIN ALDOLASE (DHNA) FROM YERSINIA PESTIS with alkylated Cys50 CO-CRYSTALLIZED with 7,8-dihydroneopterin
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1-ETHYL-PYRROLIDINE-2,5-DIONE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Bourne, C.R.
Deposit date:2021-11-16
Release date:2022-12-28
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:DIHYDRONEOPTERIN ALDOLASE (DHNA) FROM YERSINIA PESTIS with alkylated Cys50 CO-CRYSTALLIZED with 7,8-dihydroneopterin
To Be Published
2K0R
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BU of 2k0r by Molmil
Solution structure of the C103S mutant of the N-terminal Domain of DsbD from Neisseria meningitidis
Descriptor: Thiol:disulfide interchange protein dsbD
Authors:Quinternet, M, Selme, L, Tsan, P, Beaufils, C, Jacob, C, Boschi-Muller, S, Averlant-Petit, M, Branlant, G, Cung, M.
Deposit date:2008-02-13
Release date:2008-11-11
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure and backbone dynamics of the cysteine 103 to serine mutant of the N-terminal domain of DsbD from Neisseria meningitidis.
Biochemistry, 47, 2008
3OFK
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BU of 3ofk by Molmil
Crystal structure of N-methyltransferase NodS from Bradyrhizobium japonicum WM9 in complex with S-adenosyl-l-homocysteine (SAH)
Descriptor: Nodulation protein S, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Cakici, O, Sikorski, M, Stepkowski, T, Bujacz, G, Jaskolski, M.
Deposit date:2010-08-15
Release date:2010-10-27
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structures of NodS N-Methyltransferase from Bradyrhizobium japonicum in Ligand-Free Form and as SAH Complex.
J.Mol.Biol., 404, 2010
2M77
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BU of 2m77 by Molmil
[Asp2]RTD-1
Descriptor: [Asp2]RTD-1
Authors:Conibear, A.C, Bochen, A, Rosengren, K, Kessler, H, Craik, D.J.
Deposit date:2013-04-18
Release date:2014-02-05
Last modified:2024-11-20
Method:SOLUTION NMR
Cite:The Cyclic Cystine Ladder of Theta-Defensins as a Stable, Bifunctional Scaffold: A Proof-of-Concept Study Using the Integrin-Binding RGD Motif
Chembiochem, 15, 2014
8DSK
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BU of 8dsk by Molmil
Structure of the N358Y variant of serine hydroxymethyltransferase 8 in complex with PLP, glycine, and formyl tetrahydrofolate
Descriptor: 1,2-ETHANEDIOL, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, ...
Authors:Korasick, D.A, Beamer, L.J.
Deposit date:2022-07-22
Release date:2023-10-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Structural and functional analysis of two SHMT8 variants associated with soybean cyst nematode resistance.
Febs J., 291, 2024
4G56
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BU of 4g56 by Molmil
Crystal Structure of full length PRMT5/MEP50 complexes from Xenopus laevis
Descriptor: Hsl7 protein, MGC81050 protein, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Ho, M, Wilczek, C, Bonanno, J, Shechter, D, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2012-07-17
Release date:2012-10-03
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure of the arginine methyltransferase PRMT5-MEP50 reveals a mechanism for substrate specificity
Plos One, 8, 2013
2OPR
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BU of 2opr by Molmil
Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
Descriptor: ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE, Reverse transcriptase/ribonuclease H, p51 RT
Authors:Ren, J, Nichols, C.E, Chamberlain, P.P, Weaver, K.L, Short, S.A, Chan, J.H, Kleim, J, Stammers, D.K.
Deposit date:2007-01-30
Release date:2007-05-22
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases.
J.Med.Chem., 50, 2007
4G95
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BU of 4g95 by Molmil
hDHFR-OAG binary complex
Descriptor: 6-{[(2,5-dichlorophenyl)amino]methyl}pyrido[2,3-d]pyrimidine-2,4-diamine, Dihydrofolate reductase, SULFATE ION
Authors:Cody, V, Pace, J, Queener, S, Adair, O, Gangjee, A.
Deposit date:2012-07-23
Release date:2014-01-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Kinetic and structural analysis for potent antifolate inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and human dihydrofolate reductases and their active-site variants.
Antimicrob.Agents Chemother., 57, 2013

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