1TW2

Crystal structure of Carminomycin-4-O-methyltransferase (DnrK) in complex with S-adenosyl-L-homocystein (SAH) and 4-methoxy-e-rhodomycin T (M-ET)

Summary for 1TW2

Entry DOI	10.2210/pdb1tw2/pdb
Related	1QZZ 1R00 1TW3
Descriptor	Carminomycin 4-O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, METHYL (4R)-2-ETHYL-2,5,12-TRIHYDROXY-7-METHOXY-6,11-DIOXO-4-{[2,3,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-RIBO-HEXOPYRANOSYL]OXY}-1H,2H,3H,4H,6H,11H-TETRACENE-1-CARBOXYLATE, ... (4 entities in total)
Functional Keywords	anthracycline, methyltransferase, methylate, streptomyces, tailoring enzyme, polyketide, s-adenosyl-l-homocystein, structural proteomics in europe, spine, structural genomics, transferase
Biological source	Streptomyces peucetius
Total number of polymer chains	2
Total formula weight	80248.64
Authors	Jansson, A.,Koskiniemi, H.,Mantsala, P.,Niemi, J.,Schneider, G.,Structural Proteomics in Europe (SPINE) (deposition date: 2004-06-30, release date: 2004-09-14, Last modification date: 2024-04-03)
Primary citation	Jansson, A.,Koskiniemi, H.,Mantsala, P.,Niemi, J.,Schneider, G. Crystal structure of a ternary complex of DnrK, a methyltransferase in daunorubicin biosynthesis, with bound products J.Biol.Chem., 279:41149-41156, 2004 Cited by PubMed: 15273252 DOI: 10.1074/jbc.M407081200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation