4G95
hDHFR-OAG binary complex
Summary for 4G95
| Entry DOI | 10.2210/pdb4g95/pdb |
| Related | 1u72 |
| Descriptor | Dihydrofolate reductase, 6-{[(2,5-dichlorophenyl)amino]methyl}pyrido[2,3-d]pyrimidine-2,4-diamine, SULFATE ION, ... (4 entities in total) |
| Functional Keywords | dihydrofolate reductase, antifolate, oxidoreductase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 21876.84 |
| Authors | Cody, V.,Pace, J.,Queener, S.,Adair, O.,Gangjee, A. (deposition date: 2012-07-23, release date: 2014-01-29, Last modification date: 2023-09-13) |
| Primary citation | Cody, V.,Pace, J.,Queener, S.F.,Adair, O.O.,Gangjee, A. Kinetic and structural analysis for potent antifolate inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and human dihydrofolate reductases and their active-site variants. Antimicrob.Agents Chemother., 57:2669-2677, 2013 Cited by PubMed: 23545530DOI: 10.1128/AAC.00172-13 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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