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PDB: 729 results
3D44
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BU of 3d44 by Molmil
Crystal structure of HePTP in complex with a dually phosphorylated Erk2 peptide mimetic
Descriptor: CHLORIDE ION, GLYCEROL, Mitogen-activated protein kinase 1 peptide, ...
Authors:Critton, D.A, Tortajada, A, Page, R.
Deposit date:2008-05-13
Release date:2009-03-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of substrate recognition by hematopoietic tyrosine phosphatase.
Biochemistry, 47, 2008
3D9C
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BU of 3d9c by Molmil
Crystal Structure PTP1B complex with aryl Seleninic acid
Descriptor: (4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid, Tyrosine-protein phosphatase non-receptor type 1
Authors:Abdo, M, Liu, S, Zhou, B, Walls, C.D, Knapp, S, Zhang, Z.-Y.
Deposit date:2008-05-27
Release date:2008-09-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases.
J.Am.Chem.Soc., 130, 2008
3EAX
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BU of 3eax by Molmil
Crystal structure PTP1B complex with small molecule compound LZP-6
Descriptor: 4,4'-piperazine-1,4-diylbis{1-[3-(benzyloxy)phenyl]-4-oxobutane-1,3-dione}, Tyrosine-protein phosphatase non-receptor type 1
Authors:Zhang, Z.-Y, Liu, S, Zhang, L.-F, Yu, X, Xue, T, Gunawan, A.M, Long, Y.-Q.
Deposit date:2008-08-26
Release date:2009-07-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors.
J.Am.Chem.Soc., 130, 2008
1BZH
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BU of 1bzh by Molmil
Cyclic peptide inhibitor of human PTP1B
Descriptor: PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B INHIBITOR), PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B)
Authors:Groves, M.R, Yao, Z.J, Burke Jr, T.R, Barford, D.
Deposit date:1998-10-28
Release date:1999-02-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1BZJ
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BU of 1bzj by Molmil
Human ptp1b complexed with tpicooh
Descriptor: 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE)
Authors:Groves, M.R, Yao, Z.-J, Barford Jr, D.T.B.
Deposit date:1998-10-29
Release date:1999-02-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1BZC
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BU of 1bzc by Molmil
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI
Descriptor: 4-CARBAMOYL-4-{[6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBONYL]-AMINO}-BUTYRIC ACID, PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE)
Authors:Groves, M.R, Yao, Z.J, Jr Burke, T.R, Barford, D.
Deposit date:1998-10-27
Release date:1999-02-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
3EB1
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BU of 3eb1 by Molmil
Crystal structure PTP1B complex with small molecule inhibitor LZP-25
Descriptor: 4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid, Tyrosine-protein phosphatase non-receptor type 1
Authors:Liu, S, Zheng, L.-F, Wu, L, Yu, X, Xue, T, Gunawan, A.M, Long, Y.-Q, Zhang, Z.-Y.
Deposit date:2008-08-26
Release date:2009-07-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors.
J.Am.Chem.Soc., 130, 2008
3EU0
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BU of 3eu0 by Molmil
Crystal structure of the S-nitrosylated Cys215 of PTP1B
Descriptor: Tyrosine-protein phosphatase non-receptor type 1
Authors:Chu, H.M, Wang, A.H.J, Chen, Y.Y, Pan, K.T, Wang, D.L, Khoo, K.H, Meng, T.C.
Deposit date:2008-10-09
Release date:2008-11-11
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Cysteine S-Nitrosylation Protects Protein-tyrosine Phosphatase 1B against Oxidation-induced Permanent Inactivation
J.Biol.Chem., 283, 2008
1C87
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BU of 1c87 by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID
Descriptor: 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)
Authors:Iversen, L.F, Andersen, H.S, Mortensen, S.B, Moller, N.P.
Deposit date:2000-04-16
Release date:2000-05-03
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
J.Biol.Chem., 275, 2000
1C85
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BU of 1c85 by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-BENZOIC ACID
Descriptor: 2-(OXALYL-AMINO)-BENZOIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)
Authors:Andersen, H.S, Iversen, L.F, Branner, S, Rasmussen, H.B, Moller, N.P.
Deposit date:2000-04-16
Release date:2000-05-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000
1C88
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BU of 1c88 by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID
Descriptor: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)
Authors:Iversen, L.F, Andersen, H.S, Mortensen, S.B, Moller, N.P.
Deposit date:2000-04-16
Release date:2000-05-03
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
J.Biol.Chem., 275, 2000
3F99
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BU of 3f99 by Molmil
W354F Yersinia enterocolitica PTPase apo form
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase yopH
Authors:Brandao, T.A.S, Robinson, H, Johnson, S.J, Hengge, A.C.
Deposit date:2008-11-13
Release date:2009-01-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures.
J.Am.Chem.Soc., 131, 2009
1C83
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BU of 1c83 by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID
Descriptor: 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)
Authors:Andersen, H.S, Iversen, L.F, Branner, S, Rasmussen, H.B, Moller, N.P.
Deposit date:2000-04-14
Release date:2000-05-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000
1C84
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BU of 1c84 by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXLIC ACID
Descriptor: 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)
Authors:Andersen, H.S, Iversen, L.F, Branner, S, Rasmussen, H.B, Moller, N.P.
Deposit date:2000-04-14
Release date:2000-05-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000
1C86
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BU of 1c86 by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (R47V,D48N) COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID
Descriptor: 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B)
Authors:Iversen, L.F, Andersen, H.S, Mortensen, S.B, Moller, N.P.
Deposit date:2000-04-16
Release date:2000-05-03
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
J.Biol.Chem., 275, 2000
3F9B
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BU of 3f9b by Molmil
W354F Yersinia enterocolitica PTPase complexed with divanadate
Descriptor: Divanadate ion, GLYCEROL, Tyrosine-protein phosphatase yopH, ...
Authors:Brandao, T.A.S, Robinson, H, Johnson, S.J, Hengge, A.C.
Deposit date:2008-11-13
Release date:2009-01-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures.
J.Am.Chem.Soc., 131, 2009
3F9A
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BU of 3f9a by Molmil
W354F Yersinia enterocolitica PTPase complexed with tungstate
Descriptor: TUNGSTATE(VI)ION, Tyrosine-protein phosphatase yopH
Authors:Brandao, T.A.S, Robinson, H, Johnson, S.J, Hengge, A.C.
Deposit date:2008-11-13
Release date:2009-01-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures.
J.Am.Chem.Soc., 131, 2009
3H2X
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BU of 3h2x by Molmil
Crystal Structure of The Human Lymphoid Tyrosine Phosphatase Catalytic Domain
Descriptor: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 22
Authors:Tsai, S.J, Sen, U.
Deposit date:2009-04-14
Release date:2009-06-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain: insights into redox regulation .
Biochemistry, 48, 2009
3I36
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BU of 3i36 by Molmil
Crystal Structure of Rat Protein Tyrosine Phosphatase eta Catalytic Domain
Descriptor: CHLORIDE ION, Vascular protein tyrosine phosphatase 1
Authors:Nascimento, A.S, Matozo, H.C, Santos, M.A, Polikarpov, I.
Deposit date:2009-06-30
Release date:2010-06-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.841 Å)
Cite:To be Published
To be Published
4BPC
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BU of 4bpc by Molmil
Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form
Descriptor: RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE S
Authors:Jeon, T.J, Chien, P.N, Chun, H.J, Ryu, S.E.
Deposit date:2013-05-24
Release date:2013-07-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the Catalytic Domain of Protein Tyrosine Phosphatase Sigma in the Sulfenic Acid Form
Mol.Cells, 36, 2013
4GE6
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BU of 4ge6 by Molmil
Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 7
Descriptor: N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithyl-3-{[(4-hydroxy-3-methoxyphenyl)acetyl]amino}-D-alaninamide, Tyrosine-protein phosphatase non-receptor type 9
Authors:Zhang, Z.-Y, Liu, S, Zhang, S.
Deposit date:2012-08-01
Release date:2012-10-31
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes.
J.Am.Chem.Soc., 134, 2012
4GE2
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BU of 4ge2 by Molmil
Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 3
Descriptor: N-acetyl-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide, Tyrosine-protein phosphatase non-receptor type 9
Authors:Zhang, Z.-Y, Liu, S, Zhang, S.
Deposit date:2012-08-01
Release date:2012-10-31
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes.
J.Am.Chem.Soc., 134, 2012
4GFU
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BU of 4gfu by Molmil
PTPN18 in complex with HER2-pY1248 phosphor-peptides
Descriptor: HER2-pY1248 phosphor-peptide, Tyrosine-protein phosphatase non-receptor type 18
Authors:Wang, H.M, Yang, F, Du, Y.J, Yang, D.X, Zhang, Y, Yu, X, Sun, J.P.
Deposit date:2012-08-04
Release date:2013-08-07
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:PTPN18-HER2 peptides
To be Published
4GFV
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BU of 4gfv by Molmil
PTPN18 in complex with HER2-pY1196 phosphor-peptides
Descriptor: HER2-pY1196 phosphor-peptide, Tyrosine-protein phosphatase non-receptor type 18
Authors:Wang, H.M, Yang, F, Du, Y.J, Yang, D.X, Zhang, Y, Yu, X, Sun, J.P.
Deposit date:2012-08-04
Release date:2013-10-23
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.095 Å)
Cite:PTPN18-HER2 peptides
To be Published
4GE5
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BU of 4ge5 by Molmil
Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 5
Descriptor: N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide, Tyrosine-protein phosphatase non-receptor type 9
Authors:Zhang, Z.-Y, Liu, S, Zhang, S.
Deposit date:2012-08-01
Release date:2012-10-31
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes.
J.Am.Chem.Soc., 134, 2012

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