3EU0

Crystal structure of the S-nitrosylated Cys215 of PTP1B

Summary for 3EU0

Entry DOI	10.2210/pdb3eu0/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 1 (2 entities in total)
Functional Keywords	s-nitrosylated protein, hydrolase, acetylation, endoplasmic reticulum, membrane, oxidation, phosphoprotein, polymorphism, protein phosphatase
Biological source	Homo sapiens (Human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	1
Total formula weight	38223.51
Authors	Chu, H.M.,Wang, A.H.J.,Chen, Y.Y.,Pan, K.T.,Wang, D.L.,Khoo, K.H.,Meng, T.C. (deposition date: 2008-10-09, release date: 2008-11-11, Last modification date: 2023-11-01)
Primary citation	Chen, Y.Y.,Chu, H.M.,Pan, K.T.,Teng, C.H.,Wang, D.L.,Wang, A.H.,Khoo, K.H.,Meng, T.C. Cysteine S-Nitrosylation Protects Protein-tyrosine Phosphatase 1B against Oxidation-induced Permanent Inactivation J.Biol.Chem., 283:35265-35272, 2008 Cited by PubMed: 18840608 DOI: 10.1074/jbc.M805287200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation