4GE6

Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 7

Summary for 4GE6

Entry DOI	10.2210/pdb4ge6/pdb
Related	4GE2 4GE5
Descriptor	Tyrosine-protein phosphatase non-receptor type 9, N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithyl-3-{[(4-hydroxy-3-methoxyphenyl)acetyl]amino}-D-alaninamide (3 entities in total)
Functional Keywords	hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (Probable): P43378
Total number of polymer chains	2
Total formula weight	73543.73
Authors	Zhang, Z.-Y.,Liu, S.,Zhang, S. (deposition date: 2012-08-01, release date: 2012-10-31, Last modification date: 2023-09-13)
Primary citation	Zhang, S.,Liu, S.,Tao, R.,Wei, D.,Chen, L.,Shen, W.,Yu, Z.H.,Wang, L.,Jones, D.R.,Dong, X.C.,Zhang, Z.Y. A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes. J.Am.Chem.Soc., 134:18116-18124, 2012 Cited by PubMed: 23075115 DOI: 10.1021/ja308212y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation