4GE6

Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 7

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Tyrosine-protein phosphatase non-receptor type 9	polymer	314	36229.1	2	UniProt (P43378) Pfam (PF00102) In PDB	Homo sapiens (human)	Protein-tyrosine phosphatase MEG2, PTPase MEG2
2	A	N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithyl-3-{[(4-hydroxy-3-methoxyphenyl)acetyl]amino}-D-alaninamide	non-polymer		1085.6	1	Chemie (B26)
3		water	water		18.0	200	Chemie (HOH)

Sequence modifications

A, B: 277 - 582 (UniProt: P43378)

PDB	External Database	Details
Met 276	-	initiating methionine
Ala 583	-	expression tag
His 584	-	expression tag
His 585	-	expression tag
His 586	-	expression tag
His 587	-	expression tag
His 588	-	expression tag
His 589	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72458.1
Non-Polymers*	Number of molecules	1
	Total formula weight	1085.6
All*	Total formula weight	73543.7

*Water molecules are not included.