3D9C
Crystal Structure PTP1B complex with aryl Seleninic acid
Summary for 3D9C
| Entry DOI | 10.2210/pdb3d9c/pdb |
| Descriptor | Tyrosine-protein phosphatase non-receptor type 1, (4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid (3 entities in total) |
| Functional Keywords | inhibitor, covalent bond, acetylation, endoplasmic reticulum, hydrolase, membrane, oxidation, phosphoprotein, polymorphism, protein phosphatase |
| Biological source | Homo sapiens (human) |
| Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
| Total number of polymer chains | 1 |
| Total formula weight | 37769.95 |
| Authors | Abdo, M.,Liu, S.,Zhou, B.,Walls, C.D.,Knapp, S.,Zhang, Z.-Y. (deposition date: 2008-05-27, release date: 2008-09-23, Last modification date: 2024-02-21) |
| Primary citation | Abdo, M.,Liu, S.,Zhou, B.,Walls, C.D.,Wu, L.,Knapp, S.,Zhang, Z.Y. Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases. J.Am.Chem.Soc., 130:13196-13197, 2008 Cited by PubMed Abstract: A homotyrosine based seleninic acid irreversibly inhibits protein tyrosine phosphatases by forming a covalent selenosulfide linkage with the active site cysteine sulfhydryl specifically. The details of the event are revealed by model synthetic studies and by kinetic, mass spectrometric, and crystallographic characterization. PubMed: 18781746DOI: 10.1021/ja804489m PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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