1S4X
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![BU of 1s4x by Molmil](/molmil-images/mine/1s4x) | NMR Structure of the integrin B3 cytoplasmic domain in DPC micelles | Descriptor: | Integrin beta-3 | Authors: | Vinogradova, O, Vaynberg, J, Kong, X, Haas, T.A, Plow, E.F, Qin, J. | Deposit date: | 2004-01-19 | Release date: | 2004-03-09 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Membrane-mediated structural transitions at the cytoplasmic face during integrin activation. Proc.Natl.Acad.Sci.USA, 101, 2004
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5ZAZ
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![BU of 5zaz by Molmil](/molmil-images/mine/5zaz) | |
2KV9
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![BU of 2kv9 by Molmil](/molmil-images/mine/2kv9) | Integrin beta3 subunit in a disulfide linked alphaIIb-beta3 cytosolic domain | Descriptor: | Integrin beta-3 | Authors: | Metcalf, D.G, Kielec, J.M, Valentine, K.G, Wand, A, Bennett, J.S, William, D.F, Moore, D.T, Molnar, K. | Deposit date: | 2010-03-10 | Release date: | 2011-01-12 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR analysis of the {alpha}IIb{beta}3 cytoplasmic interaction suggests a mechanism for integrin regulation. Proc.Natl.Acad.Sci.USA, 107, 2010
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2LJD
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![BU of 2ljd by Molmil](/molmil-images/mine/2ljd) | |
2LJF
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![BU of 2ljf by Molmil](/molmil-images/mine/2ljf) | |
2LJE
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![BU of 2lje by Molmil](/molmil-images/mine/2lje) | |
8ZJF
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![BU of 8zjf by Molmil](/molmil-images/mine/8zjf) | Cryo-EM structure of human integrin alpha-E beta-7 | Descriptor: | CALCIUM ION, Integrin alpha-E, Integrin beta-7, ... | Authors: | Akasaka, H, Nureki, O, Kise, Y. | Deposit date: | 2024-05-14 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Cryo-EM structure of I domain-containing integrin alpha E beta 7. Biochem.Biophys.Res.Commun., 721, 2024
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7S47
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![BU of 7s47 by Molmil](/molmil-images/mine/7s47) | Integrin beta5(743-774)-linker-PAK4cat(D440N/S474E) | Descriptor: | Integrin beta-5, Isoform 2 of Serine/threonine-protein kinase PAK 4 chimera, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Ha, B.H, Boggon, T.J. | Deposit date: | 2021-09-08 | Release date: | 2022-11-09 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4) Commun Biol, 5, 2022
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1M8O
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![BU of 1m8o by Molmil](/molmil-images/mine/1m8o) | Platelet integrin alfaIIb-beta3 cytoplasmic domain | Descriptor: | platelet integrin alfaIIb subunit: cytoplasmic domain, platelet integrin beta3 subunit: cytoplasmic domain | Authors: | Vinogradova, O, Velyvis, A, Velyviene, A, Hu, B, Haas, T, Plow, E.F, Qin, J. | Deposit date: | 2002-07-25 | Release date: | 2002-09-18 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | A Structural mechanism of integrin alfaiib beta3
"Inside-out" Activation as regulated by its cytoplasmic face. Cell(Cambridge,Mass.), 110, 2002
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6VGU
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![BU of 6vgu by Molmil](/molmil-images/mine/6vgu) | |
7LA4
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![BU of 7la4 by Molmil](/molmil-images/mine/7la4) | Integrin AlphaIIbBeta3-PT25-2 Complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Bush, M.W, Walz, T, Coller, B, Filizola, M, Spasic, A, Nesic, D, Li, J. | Deposit date: | 2021-01-05 | Release date: | 2022-01-12 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin alpha IIb beta 3 for ligand binding. Blood Adv, 5, 2021
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4UM8
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![BU of 4um8 by Molmil](/molmil-images/mine/4um8) | Crystal structure of alpha V beta 6 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, ... | Authors: | Dong, X, Springer, T.A. | Deposit date: | 2014-05-15 | Release date: | 2014-11-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.852 Å) | Cite: | Structural Determinants of Integrin Beta-Subunit Specificity for Latent Tgf-Beta Nat.Struct.Mol.Biol., 21, 2014
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3G9W
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![BU of 3g9w by Molmil](/molmil-images/mine/3g9w) | Crystal Structure of Talin2 F2-F3 in Complex with the Integrin Beta1D Cytoplasmic Tail | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Integrin beta-1D, ... | Authors: | Anthis, N.J, Wegener, K.L, Ye, F, Kim, C, Lowe, E.D, Vakonakis, I, Bate, N, Critchley, D.R, Ginsberg, M.H, Campbell, I.D. | Deposit date: | 2009-02-15 | Release date: | 2009-10-20 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.165 Å) | Cite: | The structure of an integrin/talin complex reveals the basis of inside-out signal transduction Embo J., 28, 2009
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2BRQ
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![BU of 2brq by Molmil](/molmil-images/mine/2brq) | |
1KUZ
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![BU of 1kuz by Molmil](/molmil-images/mine/1kuz) | |
1KUP
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![BU of 1kup by Molmil](/molmil-images/mine/1kup) | |
7NXD
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![BU of 7nxd by Molmil](/molmil-images/mine/7nxd) | Cryo-EM structure of human integrin alpha5beta1 in the half-bent conformation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Schumacher, S, Dedden, D, Vazquez Nunez, R, Matoba, K, Takagi, J, Biertumpfel, C, Mizuno, N. | Deposit date: | 2021-03-18 | Release date: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structural insights into integrin alpha 5 beta 1 opening by fibronectin ligand. Sci Adv, 7, 2021
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8T2U
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![BU of 8t2u by Molmil](/molmil-images/mine/8t2u) | Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids complexed with Eptifibatide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A. | Deposit date: | 2023-06-06 | Release date: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids. Nat Commun, 14, 2023
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8T2V
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![BU of 8t2v by Molmil](/molmil-images/mine/8t2v) | Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A. | Deposit date: | 2023-06-06 | Release date: | 2023-07-26 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids. Nat Commun, 14, 2023
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7NWL
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![BU of 7nwl by Molmil](/molmil-images/mine/7nwl) | Cryo-EM structure of human integrin alpha5beta1 (open form) in complex with fibronectin and TS2/16 Fv-clasp | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin alpha-5, ... | Authors: | Schumacher, S, Dedden, D, Vazquez Nunez, R, Matoba, K, Takagi, J, Biertumpfel, C, Mizuno, N. | Deposit date: | 2021-03-17 | Release date: | 2021-06-02 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into integrin alpha 5 beta 1 opening by fibronectin ligand. Sci Adv, 7, 2021
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8GCE
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![BU of 8gce by Molmil](/molmil-images/mine/8gce) | The Extracellular Domain of Integrin AlphaIIbBeta3 in Intermediate State | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Huo, T, Wu, H, Wang, Z. | Deposit date: | 2023-03-01 | Release date: | 2024-03-06 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Full-length alpha IIb beta 3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture. Structure, 32, 2024
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8GCD
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![BU of 8gcd by Molmil](/molmil-images/mine/8gcd) | Full length Integrin AlphaIIbBeta3 in inactive state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Huo, T, Wu, H, Wang, Z. | Deposit date: | 2023-03-01 | Release date: | 2024-03-06 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Full-length alpha IIb beta 3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture. Structure, 32, 2024
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2L1C
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![BU of 2l1c by Molmil](/molmil-images/mine/2l1c) | |
2JF1
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![BU of 2jf1 by Molmil](/molmil-images/mine/2jf1) | |
2MTP
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![BU of 2mtp by Molmil](/molmil-images/mine/2mtp) | |