2JF1
CRYSTAL STRUCTURE OF THE FILAMIN A REPEAT 21 COMPLEXED WITH THE INTEGRIN BETA2 CYTOPLASMIC TAIL PEPTIDE
Summary for 2JF1
Entry DOI | 10.2210/pdb2jf1/pdb |
Related | 1JX3 1L3Y 1YUK |
Descriptor | FILAMIN-A, INTEGRIN BETA-2 SUBUNIT, GLYCEROL, ... (4 entities in total) |
Functional Keywords | actin-binding, cell adhesion, transmembrane, acetylation, polymorphism, cytoskeleton, glycoprotein, filamin, complex, membrane, integrin, receptor, pyrrolidone carboxylic acid, phosphorylation, disease mutation, immunoglobulin like |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cytoplasm, cell cortex: P21333 Membrane; Single-pass type I membrane protein: P05107 |
Total number of polymer chains | 2 |
Total formula weight | 14270.84 |
Authors | Kiema, T.,Ylanne, J. (deposition date: 2007-01-25, release date: 2008-02-05, Last modification date: 2023-12-13) |
Primary citation | Takala, H.,Nurminen, E.,Nurmi, S.M.,Aatonen, M.,Strandin, T.,Takatalo, M.,Kiema, T.,Gahmberg, C.G.,Ylanne, J.,Fagerholm, S.C. Beta2 Integrin Phosphorylation on Thr758 Acts as a Molecular Switch to Regulate 14-3-3 and Filamin Binding. Blood, 112:1853-, 2008 Cited by PubMed: 18550856DOI: 10.1182/BLOOD-2007-12-127795 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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