2VXC
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2VXB
| Structure of the Crb2-BRCT2 domain | Descriptor: | DNA REPAIR PROTEIN RHP9, PRASEODYMIUM ION | Authors: | Kilkenny, M.L, Roe, S.M, Pearl, L.H. | Deposit date: | 2008-07-03 | Release date: | 2008-08-12 | Last modified: | 2019-05-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and Functional Analysis of the Crb2-Brct2 Domain Reveals Distinct Roles in Checkpoint Signaling and DNA Damage Repair. Genes Dev., 22, 2008
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4BU1
| Crystal structure of Rad4 BRCT1,2 in complex with a Crb2 phosphopeptide | Descriptor: | 1,2-ETHANEDIOL, DNA REPAIR PROTEIN RHP9, GLYCEROL, ... | Authors: | Qu, M, Rappas, M, Wardlaw, C.P, Garcia, V, Carr, A.M, Oliver, A.W, Du, L.L, Pearl, L.H. | Deposit date: | 2013-06-19 | Release date: | 2013-10-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(Topbp1.). Mol.Cell, 51, 2013
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4BMC
| Crystal structure of s.pombe Rad4 BRCT1,2 | Descriptor: | CHLORIDE ION, S-M CHECKPOINT CONTROL PROTEIN RAD4 | Authors: | Meng, Q, Rappas, M, Wardlaw, C.P, Garcia, V, Carr, A.M, Oliver, A.W, Du, L.L, Pearl, L.H. | Deposit date: | 2013-05-07 | Release date: | 2013-10-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.982 Å) | Cite: | Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(Topbp1.). Mol.Cell, 51, 2013
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4BU0
| Crystal structure of Rad4 BRCT1,2 in complex with a Crb2 phosphopeptide | Descriptor: | ACETATE ION, DNA REPAIR PROTEIN RHP9, GLYCEROL, ... | Authors: | Qu, M, Rappas, M, Wardlaw, C.P, Garcia, V, Carr, A.M, Oliver, A.W, Du, L.L, Pearl, L.H. | Deposit date: | 2013-06-19 | Release date: | 2013-10-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(Topbp1.). Mol.Cell, 51, 2013
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3II6
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6HM4
| Crystal structure of Rad4 BRCT1,2 in complex with a Mdb1 phosphopeptide | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, DNA damage response protein Mdb1, ... | Authors: | Day, M, Rappas, M, Oliver, A.W, Pearl, L.H. | Deposit date: | 2018-09-12 | Release date: | 2018-10-17 | Method: | X-RAY DIFFRACTION (1.770186 Å) | Cite: | BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands. Elife, 7, 2018
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6HM3
| Crystal structure of Rad4 BRCT1,2 in complex with a Sld3 phosphopeptide | Descriptor: | CALCIUM ION, DNA replication regulator sld3, GLYCEROL, ... | Authors: | Day, M, Rappas, M, Oliver, A.W, Pearl, L.H. | Deposit date: | 2018-09-12 | Release date: | 2018-10-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.77263618 Å) | Cite: | BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands. Elife, 7, 2018
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6HM5
| Crystal structure of TOPBP1 BRCT0,1,2 in complex with a RAD9 phosphopeptide | Descriptor: | Cell cycle checkpoint control protein RAD9A, DNA topoisomerase II binding protein 1 | Authors: | Day, M, Rappas, M, Oliver, A.W, Pearl, L.H. | Deposit date: | 2018-09-12 | Release date: | 2018-10-17 | Method: | X-RAY DIFFRACTION (2.330038 Å) | Cite: | BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands. Elife, 7, 2018
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6L30
| Crystal structure of the epithelial cell transforming 2 (ECT2) | Descriptor: | Protein ECT2 | Authors: | Chen, Z.C, Chen, M.R, Pan, H, Sun, L.F, Shi, P. | Deposit date: | 2019-10-07 | Release date: | 2020-01-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure and regulation of human epithelial cell transforming 2 protein. Proc.Natl.Acad.Sci.USA, 117, 2020
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7E8I
| Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin | Descriptor: | BRCA1-associated RING domain protein 1, DNA (145-MER), Histone H2A, ... | Authors: | Dai, Y, Dai, L, Zhou, Z. | Deposit date: | 2021-03-01 | Release date: | 2021-06-30 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin. Mol.Cell, 81, 2021
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6G2I
| Filament of acetyl-CoA carboxylase and BRCT domains of BRCA1 (ACC-BRCT) at 5.9 A resolution | Descriptor: | Acetyl-CoA carboxylase 1, Breast cancer type 1 susceptibility protein | Authors: | Hunkeler, M, Hagmann, A, Stuttfeld, E, Chami, M, Stahlberg, H, Maier, T. | Deposit date: | 2018-03-23 | Release date: | 2018-06-13 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Structural basis for regulation of human acetyl-CoA carboxylase. Nature, 558, 2018
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7NFC
| Cryo-EM structure of NHEJ super-complex (dimer) | Descriptor: | DNA (27-MER), DNA (28-MER), DNA ligase 4, ... | Authors: | Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L. | Deposit date: | 2021-02-05 | Release date: | 2021-08-18 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.14 Å) | Cite: | Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. Mol.Cell, 81, 2021
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7NFE
| Cryo-EM structure of NHEJ super-complex (monomer) | Descriptor: | DNA (5'-D(P*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*CP*TP*AP*TP*TP*AP*TP*TP*AP*TP*G)-3'), DNA (5'-D(P*TP*AP*AP*TP*AP*AP*TP*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*AP*G)-3'), DNA ligase 4, ... | Authors: | Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L. | Deposit date: | 2021-02-06 | Release date: | 2021-08-18 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.29 Å) | Cite: | Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. Mol.Cell, 81, 2021
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7SCY
| Nuc147 bound to single BRCT | Descriptor: | DNA (147-MER), Histone H2A, Histone H2B type 1-J, ... | Authors: | Muthurajan, U.M, Rudolph, J.R. | Deposit date: | 2021-09-29 | Release date: | 2022-01-12 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer. Mol.Cell, 81, 2021
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7SCZ
| Nuc147 bound to multiple BRCTs | Descriptor: | DNA (147-MER), Histone H2A, Histone H2B type 1-J, ... | Authors: | Muthurajan, U.M, Rudolph, J. | Deposit date: | 2021-09-29 | Release date: | 2022-01-19 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer. Mol.Cell, 81, 2021
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8OFF
| Structure of BARD1 ARD-BRCTs in complex with H2AKc15ub nucleosomes (Map1) | Descriptor: | BRCA1 associated RING domain 1, DNA (142-MER), Histone H2A type 1, ... | Authors: | Foglizzo, M, Burdett, H, Wilson, M.D, Zeqiraj, E. | Deposit date: | 2023-03-15 | Release date: | 2023-10-11 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | BRCA1-BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes. Nucleic Acids Res., 51, 2023
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7LYC
| Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A Lys13 and Lys15 in complex with BARD1 (residues 415-777) | Descriptor: | BRCA1-associated RING domain protein 1, DNA (146-MER), DNA (147-MER), ... | Authors: | Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G. | Deposit date: | 2021-03-06 | Release date: | 2021-06-16 | Last modified: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation. Nature, 596, 2021
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7LT3
| NHEJ Long-range synaptic complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (30-MER), DNA (31-MER), ... | Authors: | He, Y, Chen, S. | Deposit date: | 2021-02-18 | Release date: | 2021-04-14 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structural basis of long-range to short-range synaptic transition in NHEJ. Nature, 593, 2021
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8BOT
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8BAH
| Human Mre11-Nbs1 complex | Descriptor: | Double-strand break repair protein MRE11, MANGANESE (II) ION, Nibrin | Authors: | Bartho, J.D, Rotheneder, M, Stakyte, K, Lammens, K, Hopfner, K.P. | Deposit date: | 2022-10-11 | Release date: | 2023-01-11 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (4.13 Å) | Cite: | Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions. Mol.Cell, 83, 2023
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8BH3
| DNA-PK Ku80 mediated dimer bound to PAXX | Descriptor: | DNA (25-MER), DNA (26-MER), DNA (27-MER), ... | Authors: | Hardwick, S.W, Chaplin, A.K. | Deposit date: | 2022-10-28 | Release date: | 2023-06-07 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (4.55 Å) | Cite: | PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Sci Adv, 9, 2023
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8BHV
| DNA-PK XLF mediated dimer bound to PAXX | Descriptor: | DNA (24-MER), DNA (26-MER), DNA (27-MER), ... | Authors: | Hardwick, S.W, Chaplin, A.K. | Deposit date: | 2022-11-01 | Release date: | 2023-06-07 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (4.51 Å) | Cite: | PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Sci Adv, 9, 2023
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8BHY
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8PV2
| Chaetomium thermophilum pre-60S State 10 - pre-5S rotation with Ytm1-Erb1 | Descriptor: | 26S rRNA, 5.8S rRNA, 5S rRNA, ... | Authors: | Thoms, M, Cheng, J, Denk, T, Berninghausen, O, Beckmann, R. | Deposit date: | 2023-07-17 | Release date: | 2023-11-15 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (2.63 Å) | Cite: | Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation. Embo Rep., 24, 2023
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