7LYC

Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A Lys13 and Lys15 in complex with BARD1 (residues 415-777)

Summary for 7LYC

• Entry DOI: 10.2210/pdb7lyc/pdb
• EMDB information: 23590 23591 23592
• Descriptor: Histone H3.1, Histone H4, Histone H2B type 1-J, ... (8 entities in total)
• Functional Keywords: nucleosome core particle, chromatin, brca1, bard1, dna repair, dna double-strand break, homologous recombination, 53bp1, ard domain, ankyrine repeat domain, tandem brct domain, ubiquitin, structural protein-dna complex, structural protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 12
• Total formula weight: 251070.87

Authors

Hu, Q.,Botuyan, M.V.,Zhao, D.,Cui, D.,Mer, E.,Mer, G. (deposition date: 2021-03-06, release date: 2021-06-16, Last modification date: 2021-09-01)

• Primary citation: Hu, Q.,Botuyan, M.V.,Zhao, D.,Cui, G.,Mer, E.,Mer, G.; Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.; Nature, 596:438-443, 2021; PubMed: 34321665; DOI: 10.1038/s41586-021-03716-8

Experimental method

ELECTRON MICROSCOPY (2.94 Å)