6V9H
| Ankyrin repeat and SOCS-box protein 9 (ASB9), ElonginB (ELOB), and ElonginC (ELOC) bound to its substrate Brain-type Creatine Kinase (CKB) | Descriptor: | Ankyrin repeat and SOCS box protein 9, Creatine kinase B-type, Elongin-B, ... | Authors: | Komives, E.A, Lumpkin, R.J, Baker, R.W, Leschziner, A.E. | Deposit date: | 2019-12-13 | Release date: | 2020-04-29 | Last modified: | 2020-11-11 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structure and dynamics of the ASB9 CUL-RING E3 Ligase. Nat Commun, 11, 2020
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6W2S
| Structure of the Cricket Paralysis Virus 5-UTR IRES (CrPV 5-UTR-IRES) bound to the small ribosomal subunit in the open state (Class 1) | Descriptor: | 18S rRNA, CrPV 5'-UTR IRES, Eukaryotic translation initiation factor 3 subunit A, ... | Authors: | Neupane, R, Pisareva, V, Rodriguez, C.F, Pisarev, A, Fernandez, I.S. | Deposit date: | 2020-03-08 | Release date: | 2020-04-22 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | A complex IRES at the 5'-UTR of a viral mRNA assembles a functional 48S complex via an uAUG intermediate. Elife, 9, 2020
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6W9D
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6VW2
| Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils | Descriptor: | Islet amyloid polypeptide (SUMO-tagged) | Authors: | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | Deposit date: | 2020-02-18 | Release date: | 2020-06-10 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils. Nat.Struct.Mol.Biol., 27, 2020
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6W2T
| Structure of the Cricket Paralysis Virus 5-UTR IRES (CrPV 5-UTR-IRES) bound to the small ribosomal subunit in the closed state (Class 2) | Descriptor: | 18S rRNA, CrPV 5'-UTR IRES, Eukaryotic translation initiation factor 3 subunit A, ... | Authors: | Neupane, R, Pisareva, V, Rodriguez, C.F, Pisarev, A, Fernandez, I.S. | Deposit date: | 2020-03-08 | Release date: | 2020-04-22 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | A complex IRES at the 5'-UTR of a viral mRNA assembles a functional 48S complex via an uAUG intermediate. Elife, 9, 2020
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6WKR
| PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome | Descriptor: | DNA (314-MER), Histone H2A type 1, Histone H2B 1.1, ... | Authors: | Kasinath, V, Nogales, E, Beck, C, Sauer, P, Poepsel, S, Kosmatka, J, Faini, M, Toso, D, Aebersold, R. | Deposit date: | 2020-04-16 | Release date: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications. Science, 371, 2021
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6WJD
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4ZUX
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5A5B
| Structure of the 26S proteasome-Ubp6 complex | Descriptor: | 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG, 26S PROTEASE REGULATORY SUBUNIT 6A, 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG, ... | Authors: | Aufderheide, A, Beck, F, Stengel, F, Hartwig, M, Schweitzer, A, Pfeifer, G, Goldberg, A.L, Sakata, E, Baumeister, W, Foerster, F. | Deposit date: | 2015-06-17 | Release date: | 2015-07-22 | Last modified: | 2017-08-30 | Method: | ELECTRON MICROSCOPY (9.5 Å) | Cite: | Structural Characterization of the Interaction of Ubp6 with the 26S Proteasome. Proc.Natl.Acad.Sci.USA, 112, 2015
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5AIT
| A complex of of RNF4-RING domain, UbeV2, Ubc13-Ub (isopeptide crosslink) | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE RNF4, POLYUBIQUITIN-C, UBIQUITIN-CONJUGATING ENZYME E2 N, ... | Authors: | Branigan, E, Naismith, J.H. | Deposit date: | 2015-02-17 | Release date: | 2015-07-08 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural Basis for the Ring Catalyzed Synthesis of K63 Linked Ubiquitin Chains Nat.Struct.Mol.Biol., 22, 2015
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5AIU
| A complex of RNF4-RING domain, Ubc13-Ub (isopeptide crosslink) | Descriptor: | 1,2-ETHANEDIOL, E3 UBIQUITIN-PROTEIN LIGASE RNF4, POLYUBIQUITIN-C, ... | Authors: | Branigan, E, Naismith, J.H. | Deposit date: | 2015-02-17 | Release date: | 2015-07-08 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structural Basis for the Ring Catalyzed Synthesis of K63 Linked Ubiquitin Chains Nat.Struct.Mol.Biol., 22, 2015
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6AH0
| The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex) | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Zhan, X, Yan, C, Zhang, X, Shi, Y. | Deposit date: | 2018-08-15 | Release date: | 2018-11-14 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (5.7 Å) | Cite: | Structures of the human pre-catalytic spliceosome and its precursor spliceosome. Cell Res., 28, 2018
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6AHD
| The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Brr2, U5 small nuclear ribonucleoprotein 200 kDa helicase, ... | Authors: | Zhan, X, Yan, C, Zhang, X, Shi, Y. | Deposit date: | 2018-08-17 | Release date: | 2018-11-14 | Last modified: | 2021-06-30 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structures of the human pre-catalytic spliceosome and its precursor spliceosome. Cell Res., 28, 2018
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6AZ1
| Cryo-EM structure of the small subunit of Leishmania ribosome bound to paromomycin | Descriptor: | E-site tRNA, LACK1, MAGNESIUM ION, ... | Authors: | Shalev-Benami, M, Zhang, Y, Rozenberg, H, Matzov, D, Zimmerman, E, Bashan, A, Jaffe, C.L, Yonath, A, Skiniotis, G. | Deposit date: | 2017-09-09 | Release date: | 2017-12-06 | Last modified: | 2019-07-03 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin. Nat Commun, 8, 2017
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3A33
| UbcH5b~Ubiquitin Conjugate | Descriptor: | GLYCEROL, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2 | Authors: | Sakata, E, Satoh, T, Yamamoto, S, Yamaguchi, Y, Yagi-Utsumi, M, Kurimoto, E, Wakatsuki, S, Kato, K. | Deposit date: | 2009-06-08 | Release date: | 2009-11-24 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of UbcH5b~Ubiquitin Intermediate: Insight into the Formation of the Self-Assembled E2~Ub Conjugates Structure, 18, 2010
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6CP2
| SidC in complex with UbcH7~Ub | Descriptor: | Polyubiquitin-B, SidC, Ubiquitin-conjugating enzyme E2 L3 | Authors: | Wasilko, D.J, Huang, Q, Mao, Y. | Deposit date: | 2018-03-13 | Release date: | 2018-08-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Insights into the ubiquitin transfer cascade catalyzed by theLegionellaeffector SidC. Elife, 7, 2018
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6C5X
| Crystal Structure of SOCS1 in complex with ElonginB and ElonginC | Descriptor: | Elongin-B, Elongin-C, GP130 peptide fragment, ... | Authors: | Kershaw, N.J, Laktyushin, A, Babon, J.J. | Deposit date: | 2018-01-17 | Release date: | 2018-05-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.105 Å) | Cite: | The molecular basis of JAK/STAT inhibition by SOCS1. Nat Commun, 9, 2018
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6D4P
| Ube2D1 in complex with ubiquitin variant Ubv.D1.1 | Descriptor: | Ubiquitin Variant Ubv.D1.1, Ubiquitin-conjugating enzyme E2 D1 | Authors: | Ceccarelli, D.F, Garg, P, Sidhu, S, Sicheri, F. | Deposit date: | 2018-04-18 | Release date: | 2019-07-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes. J.Mol.Biol., 432, 2020
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6D68
| Ube2G1 in complex with ubiquitin variant Ubv.G1.1 | Descriptor: | Ubiquitin-conjugating enzyme E2 G1, Ubv.G1.1 | Authors: | Ceccarelli, D.F, Garg, P, Sidhu, S, Sicheri, F. | Deposit date: | 2018-04-20 | Release date: | 2019-07-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes. J.Mol.Biol., 432, 2020
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6D6I
| Ube2V1 in complex with ubiquitin variant Ubv.V1.1 and Ube2N/Ubc13 | Descriptor: | Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 1, Ubv.V1.1 | Authors: | Ceccarelli, D.F, Garg, P, Keszei, A, Sidhu, S, Sicheri, F. | Deposit date: | 2018-04-21 | Release date: | 2019-07-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.551 Å) | Cite: | Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes. J.Mol.Biol., 432, 2020
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5EYA
| TRIM25 RING domain in complex with Ubc13-Ub conjugate | Descriptor: | Polyubiquitin-B, Tripartite motif-containing 25 variant, Ubiquitin-conjugating enzyme E2 N, ... | Authors: | Pornillos, O, Sanchez, J.G. | Deposit date: | 2015-11-24 | Release date: | 2016-08-17 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway. Cell Rep, 16, 2016
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3PTF
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5H7S
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5FER
| Complex of TRIM25 RING with UbcH5-Ub | Descriptor: | E3 ubiquitin/ISG15 ligase TRIM25, Ubiquitin-40S ribosomal protein S27a, Ubiquitin-conjugating enzyme E2 D1, ... | Authors: | Rittinger, K, Koliopoulos, M.G, Esposito, D. | Deposit date: | 2015-12-17 | Release date: | 2016-05-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity. Embo J., 35, 2016
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5HPT
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