6GQZ
 
 | | Petrobactin-binding engineered lipocalin without ligand | | Descriptor: | Neutrophil gelatinase-associated lipocalin | | Authors: | Skerra, A, Eichinger, A. | | Deposit date: | 2018-06-08 | | Release date: | 2018-08-15 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Reprogramming Human Siderocalin To Neutralize Petrobactin, the Essential Iron Scavenger of Anthrax Bacillus.
Angew. Chem. Int. Ed. Engl., 57, 2018
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4MVK
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5N48
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4MVI
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6Z6Z
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6Z2C
 | | Engineered lipocalin C3A5 in complex with a transition state analog | | Descriptor: | 1,7,8,9,10,10-hexachloro-4-carboxypentyl-4-aza-tricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione, Neutrophil gelatinase-associated lipocalin | | Authors: | Skerra, A, Eichinger, A. | | Deposit date: | 2020-05-15 | | Release date: | 2021-05-26 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure of an engineered lipocalin that catalyzes a Diels-Alder reaction
To be published
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6S8V
 | | Structure of the high affinity Anticalin P3D11 in complex with the human CD98 heavy chain ectodomain | | Descriptor: | 1,2-ETHANEDIOL, 4F2 cell-surface antigen heavy chain, Neutrophil gelatinase-associated lipocalin | | Authors: | Schiefner, A, Deuschle, F.-C, Skerra, A. | | Deposit date: | 2019-07-10 | | Release date: | 2020-03-04 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Development of a high affinity Anticalin®directed against human CD98hc for theranostic applications.
Theranostics, 10, 2020
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4IAX
 | | Engineered human lipocalin 2 (CL31) in complex with Y-DTPA | | Descriptor: | N-{(1S,2S)-2-[bis(carboxymethyl)amino]cyclohexyl}-N-{(2R)-2-[bis(carboxymethyl)amino]-3-[4-({[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]carbamothioyl}amino)phenyl]propyl}glycine, Neutrophil gelatinase-associated lipocalin, YTTRIUM (III) ION | | Authors: | Eichinger, A, Skerra, A. | | Deposit date: | 2012-12-07 | | Release date: | 2013-06-19 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure-guided engineering of Anticalins with improved binding behavior and biochemical characteristics for application in radio-immuno imaging and/or therapy
J.Struct.Biol., 185, 2014
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6QMU
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5MHH
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8UYN
 | | Fundamental Characterization of Chelated and Crystallized Actinium in a Macromolecular Host | | Descriptor: | LANTHANUM (III) ION, N,N'-butane-1,4-diylbis[1-hydroxy-N-(3-{[(1-hydroxy-6-oxo-1,6-dihydropyridin-2-yl)carbonyl]amino}propyl)-6-oxo-1,6-dihydropyridine-2-carboxamide], Neutrophil gelatinase-associated lipocalin, ... | | Authors: | Rupert, P.B, Strong, R.K. | | Deposit date: | 2023-11-13 | | Release date: | 2024-09-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Actinium chelation and crystallization in a macromolecular scaffold.
Nat Commun, 15, 2024
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3DSZ
 | | Engineered human lipocalin 2 in complex with Y-DTPA | | Descriptor: | N-{(1S,2S)-2-[bis(carboxymethyl)amino]cyclohexyl}-N-{(2R)-2-[bis(carboxymethyl)amino]-3-[4-({[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]carbamothioyl}amino)phenyl]propyl}glycine, YTTRIUM (III) ION, engineered human lipocalin 2 | | Authors: | Eichinger, A, Skerra, A. | | Deposit date: | 2008-07-14 | | Release date: | 2009-05-19 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | High-affinity recognition of lanthanide(III) chelate complexes by a reprogrammed human lipocalin 2
J.Am.Chem.Soc., 131, 2009
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4ZHH
 | | Siderocalin-mediated recognition and cellular uptake of actinides | | Descriptor: | CHLORIDE ION, GLYCEROL, N,N'-butane-1,4-diylbis[1-hydroxy-N-(3-{[(1-hydroxy-6-oxo-1,6-dihydropyridin-2-yl)carbonyl]amino}propyl)-6-oxo-1,6-dihydropyridine-2-carboxamide], ... | | Authors: | Allred, B.E, Rupert, P.B, Gauny, S.S, An, D.D, Ralston, C.Y, Sturzbecher-Hoehne, M, Strong, R.K, Abergel, R.J. | | Deposit date: | 2015-04-24 | | Release date: | 2015-08-05 | | Last modified: | 2015-09-02 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4ZHC
 | | Siderocalin-mediated recognition and cellular uptake of actinides | | Descriptor: | ACETATE ION, N-{2-[bis(2-{[(2,3-dihydroxyphenyl)carbonyl]amino}ethyl)amino]ethyl}-1-hydroxy-6-oxo-1,6-dihydropyridine-2-carboxamide, Neutrophil gelatinase-associated lipocalin, ... | | Authors: | Allred, B.E, Rupert, P.B, Gauny, S.S, An, D.D, Ralston, C.Y, Sturzbecher-Hoehne, M, Strong, R.K, Abergel, R.J. | | Deposit date: | 2015-04-24 | | Release date: | 2015-08-05 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4ZHD
 | | Siderocalin-mediated recognition and cellular uptake of actinides | | Descriptor: | GLYCEROL, Neutrophil gelatinase-associated lipocalin, PLUTONIUM ION, ... | | Authors: | Allred, B.E, Rupert, P.B, Gauny, S.S, An, D.D, Ralston, C.Y, Sturzbecher-Hoehne, M, Strong, R.K, Abergel, R.J. | | Deposit date: | 2015-04-24 | | Release date: | 2015-08-05 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4ZHG
 | | Siderocalin-mediated recognition and cellular uptake of actinides | | Descriptor: | AMERICIUM ION, CHLORIDE ION, GLYCEROL, ... | | Authors: | Allred, B.E, Rupert, P.B, Gauny, S.S, An, D.D, Ralston, C.Y, Sturzbecher-Hoehne, M, Strong, R.K, Abergel, R.J. | | Deposit date: | 2015-04-24 | | Release date: | 2015-08-05 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides.
Proc.Natl.Acad.Sci.USA, 112, 2015
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8UZ9
 | | Fundamental Characterization of Chelated and Crystallized Actinium in a Macromolecular Host | | Descriptor: | Actinium Ion, CHLORIDE ION, N,N'-butane-1,4-diylbis[1-hydroxy-N-(3-{[(1-hydroxy-6-oxo-1,6-dihydropyridin-2-yl)carbonyl]amino}propyl)-6-oxo-1,6-dihydropyridine-2-carboxamide], ... | | Authors: | Rupert, P.B, Strong, R.K. | | Deposit date: | 2023-11-14 | | Release date: | 2024-09-25 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Actinium chelation and crystallization in a macromolecular scaffold.
Nat Commun, 15, 2024
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1X71
 | | Crystal structure of Siderocalin (NGAL, Lipocalin 2) complexed with TRENCAM-3,2-HOPO, a cepabactin analogue | | Descriptor: | 2,3-DIHYDROXYBENZAMIDE, FE (III) ION, Neutrophil gelatinase-associated lipocalin | | Authors: | Holmes, M.A, Paulsene, W, Jide, X, Ratledge, C, Strong, R.K. | | Deposit date: | 2004-08-12 | | Release date: | 2005-01-18 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Siderocalin (Lcn 2) Also Binds Carboxymycobactins, Potentially Defending against Mycobacterial Infections through Iron Sequestration
Structure, 13, 2005
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1X89
 | | Crystal structure of Siderocalin (NGAL, Lipocalin 2) complexed with Carboxymycobactin S | | Descriptor: | CARBOXYMYCOBACTIN S, Neutrophil gelatinase-associated lipocalin | | Authors: | Holmes, M.A, Paulsene, W, Jide, X, Ratledge, C, Strong, R.K. | | Deposit date: | 2004-08-17 | | Release date: | 2005-01-25 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Siderocalin (Lcn 2) Also Binds Carboxymycobactins, Potentially Defending against Mycobacterial Infections through Iron Sequestration
Structure, 13, 2005
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4QAE
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5KID
 | | Tightening the Recognition of Tetravalent Zr and Th Complexes by the Siderophore-Binding Mammalian Protein Siderocalin for Theranostic Applications | | Descriptor: | CHLORIDE ION, GLYCEROL, N,N'-(butane-1,4-diyl)bis(N-{3-[(2,3-dihydroxybenzene-1-carbonyl)amino]propyl}-2,3-dihydroxybenzamide), ... | | Authors: | Rupert, P.B, Strong, R.K. | | Deposit date: | 2016-06-16 | | Release date: | 2017-04-26 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Engineered Recognition of Tetravalent Zirconium and Thorium by Chelator-Protein Systems: Toward Flexible Radiotherapy and Imaging Platforms.
Inorg Chem, 55, 2016
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3CBC
 | | Crystal structure of Siderocalin (NGAL, Lipocalin 2) Y106F complexed with Ferric Enterobactin | | Descriptor: | 2-(2,3-DIHYDROXY-BENZOYLAMINO)-3-HYDROXY-PROPIONIC ACID, GLYCEROL, Neutrophil gelatinase-associated lipocalin, ... | | Authors: | Clifton, M.C, Pizaro, J.C, Strong, R.K. | | Deposit date: | 2008-02-21 | | Release date: | 2008-09-09 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.17 Å) | | Cite: | The siderocalin/enterobactin interaction: a link between mammalian immunity and bacterial iron transport.
J.Am.Chem.Soc., 130, 2008
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3PEC
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3HWG
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5NKN
 | | Crystal structure of an Anticalin-colchicine complex | | Descriptor: | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide, Neutrophil gelatinase-associated lipocalin | | Authors: | Skerra, A, Eichinger, A, Barkovskiy, M. | | Deposit date: | 2017-03-31 | | Release date: | 2018-04-04 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | An engineered lipocalin that tightly complexes the plant poison colchicine for use as antidote and in bioanalytical applications.
Biol. Chem., 400, 2019
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