8UYN
Fundamental Characterization of Chelated and Crystallized Actinium in a Macromolecular Host
Summary for 8UYN
| Entry DOI | 10.2210/pdb8uyn/pdb |
| Descriptor | Neutrophil gelatinase-associated lipocalin, LANTHANUM (III) ION, N,N'-butane-1,4-diylbis[1-hydroxy-N-(3-{[(1-hydroxy-6-oxo-1,6-dihydropyridin-2-yl)carbonyl]amino}propyl)-6-oxo-1,6-dihydropyridine-2-carboxamide], ... (6 entities in total) |
| Functional Keywords | inhibitor, metal binding protein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 3 |
| Total formula weight | 64736.60 |
| Authors | Rupert, P.B.,Strong, R.K. (deposition date: 2023-11-13, release date: 2024-09-25, Last modification date: 2024-11-20) |
| Primary citation | Wacker, J.N.,Woods, J.J.,Rupert, P.B.,Peterson, A.,Allaire, M.,Lukens, W.W.,Gaiser, A.N.,Minasian, S.G.,Strong, R.K.,Abergel, R.J. Actinium chelation and crystallization in a macromolecular scaffold. Nat Commun, 15:5741-5741, 2024 Cited by PubMed Abstract: Targeted alpha therapy (TAT) pairs the specificity of antigen targeting with the lethality of alpha particles to eradicate cancerous cells. Actinium-225 [Ac; t = 9.920(3) days] is an alpha-emitting radioisotope driving the next generation of TAT radiopharmaceuticals. Despite promising clinical results, a fundamental understanding of Ac coordination chemistry lags behind the rest of the Periodic Table due to its limited availability, lack of stable isotopes, and inadequate systems poised to probe the chemical behavior of this radionuclide. In this work, we demonstrate a platform that combines an 8-coordinate synthetic ligand and a mammalian protein to characterize the solution and solid-state behavior of the longest-lived Ac isotope, Ac [t = 21.772(3) years]. We expect these results to direct renewed efforts for Ac-TAT development, aid in understanding Ac coordination behavior relative to other +3 lanthanides and actinides, and more broadly inform this element's position on the Periodic Table. PubMed: 39009580DOI: 10.1038/s41467-024-50017-5 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report
