5NKN
Crystal structure of an Anticalin-colchicine complex
Summary for 5NKN
| Entry DOI | 10.2210/pdb5nkn/pdb |
| Descriptor | Neutrophil gelatinase-associated lipocalin, N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide (3 entities in total) |
| Functional Keywords | beta-barrel, colchicine, lcn2, lipocalin, ngal, protein engineering, transport protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 20342.14 |
| Authors | Skerra, A.,Eichinger, A.,Barkovskiy, M. (deposition date: 2017-03-31, release date: 2018-04-04, Last modification date: 2024-01-17) |
| Primary citation | Barkovskiy, M.,Ilyukhina, E.,Dauner, M.,Eichinger, A.,Skerra, A. An engineered lipocalin that tightly complexes the plant poison colchicine for use as antidote and in bioanalytical applications. Biol. Chem., 400:351-366, 2019 Cited by PubMed: 30517073DOI: 10.1515/hsz-2018-0342 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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