6G6K
 
 | | The crystal structures of Human MYC:MAX bHLHZip complex | | Descriptor: | CHLORIDE ION, Myc proto-oncogene protein, Protein max | | Authors: | Allen, M.D, Zinzalla, G. | | Deposit date: | 2018-04-01 | | Release date: | 2019-04-10 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA.
Biochemistry, 58, 2019
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1NKP
 | | Crystal structure of Myc-Max recognizing DNA | | Descriptor: | 5'-D(*CP*GP*AP*GP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*CP*TP*C)-3', Max protein, Myc proto-oncogene protein | | Authors: | Nair, S.K, Burley, S.K. | | Deposit date: | 2003-01-03 | | Release date: | 2003-02-04 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | X-ray structures of Myc-Max and Mad-Max recognizing DNA: Molecular bases of regulation by proto-oncogenic transcription factors
Cell(Cambridge,Mass.), 112, 2003
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1YTB
 | | CRYSTAL STRUCTURE OF A YEAST TBP/TATA-BOX COMPLEX | | Descriptor: | DNA (29MER), PROTEIN (TATA BINDING PROTEIN (TBP)) | | Authors: | Kim, Y, Geiger, J.H, Hahn, S, Sigler, P.B. | | Deposit date: | 1994-09-28 | | Release date: | 1995-01-26 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of a yeast TBP/TATA-box complex.
Nature, 365, 1993
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8Q1N
 | | Cyclic peptide binder of the WBM-site of WDR5 | | Descriptor: | Cyclic peptide inhibitor, WD repeat-containing protein 5 | | Authors: | Schmeing, S, Chang, J.Y, t Hart, P, Gasper, R. | | Deposit date: | 2023-08-01 | | Release date: | 2023-09-06 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.843 Å) | | Cite: | Macrocyclic peptides as inhibitors of WDR5-lncRNA interactions.
Chem.Commun.(Camb.), 59, 2023
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4Y7R
 | | Crystal structure of WDR5 in complex with MYC MbIIIb peptide | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MYC MbIIIb peptide, ... | | Authors: | Sun, Q, Phan, J, Olejniczak, E.T, Thomas, L.R, Fesik, S.W, Tansey, W.P. | | Deposit date: | 2015-02-16 | | Release date: | 2015-04-15 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.898 Å) | | Cite: | Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC.
Mol.Cell, 58, 2015
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1NH2
 | | Crystal structure of a yeast TFIIA/TBP/DNA complex | | Descriptor: | 5'-D(*GP*TP*TP*TP*TP*AP*TP*AP*TP*AP*CP*AP*TP*AP*CP*A)-3', 5'-D(*TP*GP*TP*AP*(5IU)P*GP*TP*AP*TP*AP*(5IU)P*AP*AP*AP*AP*C)-3', Transcription initiation factor IIA large chain, ... | | Authors: | Bleichenbacher, M, Tan, S, Richmond, T.J. | | Deposit date: | 2002-12-18 | | Release date: | 2003-10-21 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes.
J.Mol.Biol., 332, 2003
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8J2Q
 | | Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment | | Descriptor: | Polyhedrin,Myc proto-oncogene protein | | Authors: | Kojima, M, Ueno, T, Abe, S, Hirata, K. | | Deposit date: | 2023-04-15 | | Release date: | 2024-04-17 | | Last modified: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | High-throughput structure determination of an intrinsically disordered protein using cell-free protein crystallization.
Proc.Natl.Acad.Sci.USA, 121, 2024
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5I4Z
 | | Structure of apo OmoMYC | | Descriptor: | CHLORIDE ION, GLYCEROL, Myc proto-oncogene protein, ... | | Authors: | Koelmel, W, Jung, L.A, Kuper, J, Eilers, M, Kisker, C. | | Deposit date: | 2016-02-13 | | Release date: | 2016-10-26 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.
Oncogene, 36, 2017
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4B0A
 | | The high-resolution structure of yTBP-yTAF1 identifies conserved and competing interaction surfaces in transcriptional activation | | Descriptor: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | | Authors: | Anandapadamanaban, M, Andresen, C, Siponen, M, Kokubo, T, Ikura, M, Moche, M, Sunnerhagen, M. | | Deposit date: | 2012-06-29 | | Release date: | 2013-07-03 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | High-Resolution Structure of TBP with Taf1 Reveals Anchoring Patterns in Transcriptional Regulation
Nat.Struct.Mol.Biol., 20, 2013
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8X8V
 | | Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment | | Descriptor: | Polyhedrin,Myc proto-oncogene protein | | Authors: | Kojima, M, Ueno, T, Abe, S, Hirata, K. | | Deposit date: | 2023-11-29 | | Release date: | 2024-06-05 | | Last modified: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | High-throughput structure determination of an intrinsically disordered protein using cell-free protein crystallization.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8X8S
 | | Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment | | Descriptor: | Polyhedrin,Myc proto-oncogene protein | | Authors: | Kojima, M, Ueno, T, Abe, S, Hirata, K. | | Deposit date: | 2023-11-28 | | Release date: | 2024-06-05 | | Last modified: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | High-throughput structure determination of an intrinsically disordered protein using cell-free protein crystallization.
Proc.Natl.Acad.Sci.USA, 121, 2024
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1EE4
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6G6L
 | | The crystal structures of Human MYC:MAX bHLHZip complex | | Descriptor: | Myc proto-oncogene protein, Protein max, SULFATE ION | | Authors: | Allen, M.D, Zinzalla, G. | | Deposit date: | 2018-04-01 | | Release date: | 2019-04-10 | | Last modified: | 2023-04-05 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA.
Biochemistry, 58, 2019
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6G6J
 | | The crystal structures of Human MYC:MAX bHLHZip complex | | Descriptor: | Myc proto-oncogene protein, Protein max, SULFATE ION | | Authors: | Allen, M.D, Zinzalla, G. | | Deposit date: | 2018-04-01 | | Release date: | 2019-04-10 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA.
Biochemistry, 58, 2019
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6E16
 | | Ternary structure of c-Myc-TBP-TAF1 | | Descriptor: | Transcription initiation factor TFIID subunit 1,Myc proto-oncogene protein,TATA-box-binding protein | | Authors: | Wei, Y, Dong, A, Sunnerhagen, M, Penn, L, Tong, Y, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC) | | Deposit date: | 2018-07-09 | | Release date: | 2019-10-02 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Multiple direct interactions of TBP with the MYC oncoprotein.
Nat.Struct.Mol.Biol., 26, 2019
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1RM1
 | | Structure of a Yeast TFIIA/TBP/TATA-box DNA Complex | | Descriptor: | 5'-D(*AP*TP*CP*GP*AP*TP*CP*GP*AP*TP*AP*TP*AP*AP*AP*AP*CP*G)-3', 5'-D(P*CP*GP*TP*TP*TP*TP*AP*TP*AP*TP*CP*GP*AP*TP*CP*GP*AP*T)-3', TATA-box binding protein, ... | | Authors: | Jin, X, Gewirth, D.T, Geiger, J.H. | | Deposit date: | 2003-11-26 | | Release date: | 2005-07-26 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | High Resolution Structure of a Yeast TFIIA/TBP/TATA-box DNA Complex
TO BE PUBLISHED
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1YTF
 | | YEAST TFIIA/TBP/DNA COMPLEX | | Descriptor: | DNA (5'-D(*GP*TP*TP*TP*TP*AP*TP*AP*TP*AP*CP*AP*TP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*AP*TP*GP*TP*AP*TP*AP*TP*AP*AP*AP*AP*C)-3'), PROTEIN (TATA BINDING PROTEIN (TBP)), ... | | Authors: | Tan, S, Hunziker, Y, Sargent, D.F, Richmond, T.J. | | Deposit date: | 1996-04-05 | | Release date: | 1996-06-20 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of a yeast TFIIA/TBP/DNA complex.
Nature, 381, 1996
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8WLG
 | | Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment | | Descriptor: | Polyhedrin,Myc proto-oncogene protein | | Authors: | Kojima, M, Ueno, T, Abe, S, Hirata, K. | | Deposit date: | 2023-09-29 | | Release date: | 2024-06-05 | | Last modified: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | High-throughput structure determination of an intrinsically disordered protein using cell-free protein crystallization.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7T1Y
 | | Structure of the Fbw7-Skp1-MycCdegron complex | | Descriptor: | F-box/WD repeat-containing protein 7, Myc proto-oncogene protein C terminal degron, S-phase kinase-associated protein 1, ... | | Authors: | Wang, B, Rusnac, D.V, Clurman, B.E, Zheng, N. | | Deposit date: | 2021-12-02 | | Release date: | 2022-02-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor.
Sci Adv, 8, 2022
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6C4U
 | | Engineered FHA with Myc-pTBD peptide | | Descriptor: | Forkhead-associated 1, GLYCEROL, Myc-pTBD peptide | | Authors: | Kall, S.L, Lavie, A. | | Deposit date: | 2018-01-12 | | Release date: | 2018-05-30 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Generating a recombinant phosphothreonine-binding domain for a phosphopeptide of the human transcription factor, c-Myc.
N Biotechnol, 45, 2018
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1TBP
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2OR9
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5I50
 | | Structure of OmoMYC bound to double-stranded DNA | | Descriptor: | DNA (5'-D(P*CP*AP*CP*CP*CP*GP*GP*TP*CP*AP*CP*GP*TP*GP*GP*CP*CP*TP*AP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*TP*AP*GP*GP*CP*CP*AP*CP*GP*TP*GP*AP*CP*CP*GP*GP*GP*TP*G)-3'), Myc proto-oncogene protein | | Authors: | Koelmel, W, Jung, L.A, Kuper, J, Eilers, M, Kisker, C. | | Deposit date: | 2016-02-13 | | Release date: | 2016-10-26 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.701 Å) | | Cite: | OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.
Oncogene, 36, 2017
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7T1Z
 | | Structure of the Fbw7-Skp1-MycNdegron complex | | Descriptor: | F-box/WD repeat-containing protein 7, Myc proto-oncogene N terminal degron, S-phase kinase-associated protein 1, ... | | Authors: | Wang, B, Rusnac, D.V, Clurman, B.E, Zheng, N. | | Deposit date: | 2021-12-02 | | Release date: | 2022-02-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.77 Å) | | Cite: | Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor.
Sci Adv, 8, 2022
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7Z0O
 | | Structure of transcription factor UAF in complex with TBP and 35S rRNA promoter DNA | | Descriptor: | Histone H3, Histone H4, Non-template DNA, ... | | Authors: | Baudin, F, Murciano, B, Fung, H.K.H, Fromm, S.A, Mueller, C.W. | | Deposit date: | 2022-02-23 | | Release date: | 2022-04-27 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Mechanism of RNA polymerase I selection by transcription factor UAF.
Sci Adv, 8, 2022
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