4Y7R

Crystal structure of WDR5 in complex with MYC MbIIIb peptide

Summary for 4Y7R

DescriptorWD repeat-containing protein 5, MYC MbIIIb peptide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total)
Functional Keywordsmyc wdr5 cancer, dna binding protein
Biological sourceHomo sapiens (Human)
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Cellular locationNucleus  P61964
Total number of polymer chains2
Total molecular weight35464.16
Authors
Sun, Q.,Phan, J.,Olejniczak, E.T.,Thomas, L.R.,Fesik, S.W.,Tansey, W.P. (deposition date: 2015-02-16, release date: 2015-04-15, Last modification date: 2017-09-20)
Primary citation
Thomas, L.R.,Wang, Q.,Grieb, B.C.,Phan, J.,Foshage, A.M.,Sun, Q.,Olejniczak, E.T.,Clark, T.,Dey, S.,Lorey, S.,Alicie, B.,Howard, G.C.,Cawthon, B.,Ess, K.C.,Eischen, C.M.,Zhao, Z.,Fesik, S.W.,Tansey, W.P.
Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC.
Mol.Cell, 58:440-452, 2015
PubMed: 25818646 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2015.02.028
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.898 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.18620 1.8% 0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171916
PDB entries from 2020-12-02