8Q1N

Cyclic peptide binder of the WBM-site of WDR5

Summary for 8Q1N

Entry DOI	10.2210/pdb8q1n/pdb
Descriptor	WD repeat-containing protein 5, Cyclic peptide inhibitor (3 entities in total)
Functional Keywords	inhibitor, wd-repeat, gene regulation
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	73108.64
Authors	Schmeing, S.,Chang, J.Y.,t Hart, P.,Gasper, R. (deposition date: 2023-08-01, release date: 2023-09-06, Last modification date: 2023-09-13)
Primary citation	Chang, J.Y.,Neugebauer, C.,Schmeing, S.,Amrahova, G.,'t Hart, P. Macrocyclic peptides as inhibitors of WDR5-lncRNA interactions. Chem.Commun.(Camb.), 59:10656-10659, 2023 Cited by PubMed: 37581220 DOI: 10.1039/d3cc03221c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.843 Å)

Structure validation