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PDB: 132 results

8JJV
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Structure of truncated form of nanobody in complex with alpha-synuclein peptide
Descriptor: Alpha-synuclein peptide, GLYCEROL, Nanobody
Authors:Islam, Z, Kolatkar, P.R.
Deposit date:2023-05-31
Release date:2024-01-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Structural insights into the unique recognition module between alpha-synuclein peptide and nanobody.
Protein Sci., 33, 2024
8JLY
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Structure of nanobody in complex with alpha-synuclein peptide
Descriptor: GLYCEROL, Nanobody, alpha-synuclein peptide
Authors:Islam, Z, Kolatkar, P.R.
Deposit date:2023-06-04
Release date:2024-01-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Structural insights into the unique recognition module between alpha-synuclein peptide and nanobody.
Protein Sci., 33, 2024
3Q27
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BU of 3q27 by Molmil
Cyrstal structure of human alpha-synuclein (32-57) fused to maltose binding protein (MBP)
Descriptor: GLYCEROL, Maltose-binding periplasmic protein/alpha-synuclein chimeric protein, SULFATE ION, ...
Authors:Zhao, M, Sawaya, M.R, Cascio, D, Eisenberg, D.
Deposit date:2010-12-19
Release date:2011-06-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.302 Å)
Cite:Structures of segments of alpha-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation
Protein Sci., 20, 2011
4R0U
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BU of 4r0u by Molmil
Tgvtava, an amyloid forming segment from alpha synuclein, residues 72-78
Descriptor: Alpha-synuclein
Authors:Ivanova, M.I, Eisenberg, D.S, Sawaya, M.R.
Deposit date:2014-08-01
Release date:2014-12-17
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Structure-based design of functional amyloid materials.
J.Am.Chem.Soc., 136, 2014
6I42
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BU of 6i42 by Molmil
Structure of the alpha-Synuclein PreNAC/Cyclophilin A-complex
Descriptor: Alpha-synuclein, Peptidyl-prolyl cis-trans isomerase A
Authors:Favretto, F, Zweckstetter, M, Becker, S.
Deposit date:2018-11-08
Release date:2020-02-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:The Molecular Basis of the Interaction of Cyclophilin A with alpha-Synuclein.
Angew.Chem.Int.Ed.Engl., 59, 2020
4ZNN
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BU of 4znn by Molmil
MicroED structure of the segment, GVVHGVTTVA, from the A53T familial mutant of Parkinson's disease protein, alpha-synuclein residues 47-56
Descriptor: Alpha-synuclein
Authors:Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S.
Deposit date:2015-05-05
Release date:2015-09-09
Last modified:2024-03-06
Method:ELECTRON CRYSTALLOGRAPHY (1.41 Å)
Cite:Structure of the toxic core of alpha-synuclein from invisible crystals.
Nature, 525, 2015
4RIL
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BU of 4ril by Molmil
Structure of the amyloid forming segment, GAVVTGVTAVA, from the NAC domain of Parkinson's disease protein alpha-synuclein, residues 68-78, determined by electron diffraction
Descriptor: Alpha-synuclein
Authors:Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S.
Deposit date:2014-10-06
Release date:2015-08-26
Last modified:2023-09-20
Method:ELECTRON CRYSTALLOGRAPHY (1.43 Å)
Cite:Structure of the toxic core of alpha-synuclein from invisible crystals.
Nature, 525, 2015
4R0W
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Vvtgvta, an amyloid forming segment from alpha synuclein, residues 70-76
Descriptor: Alpha-synuclein
Authors:Ivanova, M.I, Eisenberg, D.S, Sawaya, M.R.
Deposit date:2014-08-01
Release date:2014-12-17
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure-based design of functional amyloid materials.
J.Am.Chem.Soc., 136, 2014
3Q26
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BU of 3q26 by Molmil
Cyrstal structure of human alpha-synuclein (10-42) fused to maltose binding protein (MBP)
Descriptor: GLYCEROL, Maltose-binding periplasmic protein/alpha-synuclein chimeric protein, SULFATE ION, ...
Authors:Zhao, M, Sawaya, M.R, Cascio, D, Eisenberg, D.
Deposit date:2010-12-19
Release date:2011-06-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Structures of segments of alpha-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation
Protein Sci., 20, 2011
3Q28
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BU of 3q28 by Molmil
Cyrstal structure of human alpha-synuclein (58-79) fused to maltose binding protein (MBP)
Descriptor: Maltose-binding periplasmic protein/alpha-synuclein chimeric protein, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Zhao, M, Sawaya, M.R, Cascio, D, Eisenberg, D.
Deposit date:2010-12-19
Release date:2011-06-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of segments of alpha-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation
Protein Sci., 20, 2011
5CRW
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BU of 5crw by Molmil
Crystal structure of the b'-a' domain of oxidized protein disulfide isomerase complexed with alpha-synuclein peptide (31-41)
Descriptor: Peptide from Alpha-synuclein, Protein disulfide-isomerase
Authors:Yagi-Utsumi, M, Satoh, T, Kato, K.
Deposit date:2015-07-23
Release date:2015-09-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis of redox-dependent substrate binding of protein disulfide isomerase.
Sci Rep, 5, 2015
2X6M
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BU of 2x6m by Molmil
Structure of a single domain camelid antibody fragment in complex with a C-terminal peptide of alpha-synuclein
Descriptor: ALPHA-SYNUCLEIN PEPTIDE, HEAVY CHAIN VARIABLE DOMAIN FROM DROMEDARY
Authors:DeGenst, E, Guilliams, T, Wellens, J, O'Day, E.M, Waudby, C.A, Meehan, S, Dumoulin, M, Hsu, S.-T.D, Cremades, N, Verschueren, K.H.G, Pardon, E, Wyns, L, Steyaert, J, Christodoulou, J, Dobson, C.M.
Deposit date:2010-02-18
Release date:2010-06-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structure and Properties of a Complex of Alpha-Synuclein and a Single-Domain Camelid Antibody.
J.Mol.Biol., 402, 2010
8OG0
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BU of 8og0 by Molmil
Crystal structure of MJF14-6-4-2 Fab fragment in complex with epitope peptide
Descriptor: Alpha-synuclein, Fab fragment heavy chain, Fab fragment light chain
Authors:Tars, K, Lieknina, I.
Deposit date:2023-03-17
Release date:2024-03-27
Method:X-RAY DIFFRACTION (1.712 Å)
Cite:Structural basis of epitope recognition by anti-alpha synuclein antibodies MJF14-6-4-2
To be published
4RIK
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BU of 4rik by Molmil
Amyloid forming segment, AVVTGVTAV, from the NAC domain of Parkinson's disease protein alpha-synuclein, residues 69-77
Descriptor: Alpha-synuclein
Authors:Guenther, E.L, Sawaya, M.R, Ivanova, M, Eisenberg, D.S.
Deposit date:2014-10-06
Release date:2015-08-26
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.854 Å)
Cite:Structure of the toxic core of alpha-synuclein from invisible crystals.
Nature, 525, 2015
3Q25
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BU of 3q25 by Molmil
Crystal structure of human alpha-synuclein (1-19) fused to maltose binding protein (MBP)
Descriptor: GLYCEROL, Maltose-binding periplasmic protein/alpha-synuclein chimeric protein, SULFATE ION, ...
Authors:Zhao, M, Sawaya, M.R, Cascio, D, Eisenberg, D.
Deposit date:2010-12-19
Release date:2011-06-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of segments of alpha-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation
Protein Sci., 20, 2011
6CT7
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BU of 6ct7 by Molmil
Fab of anti-a-synuclein antibody BIIB054 in complex with acetylated a-synuclein peptide (1-10)
Descriptor: ACE-MET-ASP-VAL-PHE-MET-LYS-GLY-LEU-SER-LYS, BIIB054 Fab heavy chain, BIIB054 Fab light chain, ...
Authors:Arndt, J.W.
Deposit date:2018-03-22
Release date:2018-12-19
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:Development of an aggregate-selective, human-derived alpha-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.
Neurobiol. Dis., 124, 2018
9EUU
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BU of 9euu by Molmil
Structure of recombinant alpha-synuclein fibrils 1B capable of seeding GCIs in vivo
Descriptor: Alpha-synuclein
Authors:Burger, D, Kashyrina, M, Lewis, A, De Nuccio, F, Mohammed, I, de La Seigliere, H, van den Heuvel, L, Feuillie, C, Verchere, J, Berbon, M, Arotcarena, M, Retailleau, A, Bezard, E, Laferriere, F, Loquet, A, Bousset, L, Baron, T, Lofrumento, D.D, De Giorgi, F, Stahlberg, H, Ichas, F.
Deposit date:2024-03-28
Release date:2024-06-05
Method:ELECTRON MICROSCOPY (1.93 Å)
Cite:Multiple System Atrophy: Insights from aSyn Fibril Structure
To Be Published
8BQV
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BU of 8bqv by Molmil
Cryo-EM structure of alpha-synuclein singlet filament from Juvenile-onset synucleinopathy
Descriptor: Alpha-synuclein, Unknown protein
Authors:Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Peak-Chew, S.Y, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M.
Deposit date:2023-01-18
Release date:2023-02-22
Last modified:2023-05-03
Method:ELECTRON MICROSCOPY (2 Å)
Cite:New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy.
Acta Neuropathol, 145, 2023
8B9V
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BU of 8b9v by Molmil
Crystal structure of Lu AF82422 in complex with alpha-synuclein 110-120
Descriptor: Alpha-synuclein 110-120, Lu AF82422 Fab heavy chain, Lu AF82422 Fab light chain, ...
Authors:Bjerregaard-Andersen, K, Carr, K, Krogh, B.O, Kallunki, P, Tagmose, L, David, L.
Deposit date:2022-10-10
Release date:2023-10-25
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Crystal structure of Lu AF82422 in complex with alpha-synuclein 110-120
To Be Published
8A9L
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BU of 8a9l by Molmil
Cryo-EM structure of alpha-synuclein filaments from Parkinson's disease and dementia with Lewy bodies
Descriptor: Alpha-synuclein, Unknown fragment
Authors:Yang, Y, Shi, Y, Schweighauser, M, Zhang, X.J, Kotecha, A, Murzin, A.G, Garringer, H.J, Cullinane, P, Saito, Y, Foroud, T, Warner, T.T, Hasegawa, K, Vidal, R, Murayama, S, Revesz, T, Ghetti, B, Hasegawa, M, Lashley, T, Scheres, H.W.S, Goedert, M.
Deposit date:2022-06-28
Release date:2022-08-31
Last modified:2022-11-09
Method:ELECTRON MICROSCOPY (2.16 Å)
Cite:Structures of alpha-synuclein filaments from human brains with Lewy pathology.
Nature, 610, 2022
3Q29
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BU of 3q29 by Molmil
Cyrstal structure of human alpha-synuclein (1-19) fused to maltose binding protein (MBP)
Descriptor: GLYCEROL, Maltose-binding periplasmic protein/alpha-synuclein chimeric protein, SULFATE ION, ...
Authors:Zhao, M, Sawaya, M.R, Cascio, D, Eisenberg, D.
Deposit date:2010-12-19
Release date:2011-06-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of segments of alpha-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation
Protein Sci., 20, 2011
8BQW
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BU of 8bqw by Molmil
Cryo-EM structure of alpha-synuclein filaments doublet from Juvenile-onset synucleinopathy
Descriptor: Alpha-synuclein, Unknown protein
Authors:Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Peak-Chew, S.Y, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M.
Deposit date:2023-01-18
Release date:2023-02-22
Last modified:2023-05-03
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy.
Acta Neuropathol, 145, 2023
8PJO
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BU of 8pjo by Molmil
Cryo EM structure of the type 3D polymorph of alpha-synuclein E46K mutant at low pH.
Descriptor: Alpha-synuclein, CHLORIDE ION
Authors:Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R.
Deposit date:2023-06-23
Release date:2024-05-29
Method:ELECTRON MICROSCOPY (2.31 Å)
Cite:On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation
Elife, 2023
8PIC
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BU of 8pic by Molmil
Cryo EM structure of the type 3B polymorph of alpha-synuclein at low pH.
Descriptor: Alpha-synuclein, CHLORIDE ION
Authors:Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R.
Deposit date:2023-06-21
Release date:2024-05-29
Method:ELECTRON MICROSCOPY (2.42 Å)
Cite:On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation
Elife, 2023
7YNF
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BU of 7ynf by Molmil
CCA-bound alpha-synuclein fibrils
Descriptor: Alpha-synuclein, copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate
Authors:Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D.
Deposit date:2022-07-30
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:CCA-bound alpha-synuclein fibrils
To Be Published

221051

PDB entries from 2024-06-12

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