8BQV

Cryo-EM structure of alpha-synuclein singlet filament from Juvenile-onset synucleinopathy

Summary for 8BQV

• Entry DOI: 10.2210/pdb8bqv/pdb
• EMDB information: 16188
• Descriptor: Alpha-synuclein, Unknown protein (3 entities in total)
• Functional Keywords: alpha-synuclein, amyloid, fibril, insertion, juvenile-onset synucleinopathy (jos), synucleinopathy, protein fibril
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 15089.86

Authors

Yang, Y.,Garringer, J.H.,Shi, Y.,Lovestam, S.,Peak-Chew, S.Y.,Zhang, X.J.,Kotecha, A.,Bacioglu, M.,Koto, A.,Takao, M.,Spillantini, G.M.,Ghetti, B.,Vidal, R.,Murzin, G.A.,Scheres, H.W.S.,Goedert, M. (deposition date: 2023-01-18, release date: 2023-02-22, Last modification date: 2023-05-03)

• Primary citation: Yang, Y.,Garringer, H.J.,Shi, Y.,Lovestam, S.,Peak-Chew, S.,Zhang, X.,Kotecha, A.,Bacioglu, M.,Koto, A.,Takao, M.,Spillantini, M.G.,Ghetti, B.,Vidal, R.,Murzin, A.G.,Scheres, S.H.W.,Goedert, M.; New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy.; Acta Neuropathol, 145:561-572, 2023; PubMed: 36847833; DOI: 10.1007/s00401-023-02550-8

Experimental method

ELECTRON MICROSCOPY (2 Å)