8YYM
 
 | | Cryo-EM structure of cylindrical fiber of MyD88 TIR | | Descriptor: | Myeloid differentiation primary response protein MyD88 | | Authors: | Kasai, K, Imamura, K, Narita, A, Makino, F, Miyata, T, Kato, T, Namba, K, Onishi, H, Tochio, H. | | Deposit date: | 2024-04-04 | | Release date: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | From Monomers to Oligomers: Structural Mechanism of Receptor-Triggered MyD88 Assembly in Innate Immune Signaling
Biorxiv, 2024
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8W8M
 | | Cryo-EM structure of helical filament of MyD88 TIR | | Descriptor: | Myeloid differentiation primary response protein MyD88 | | Authors: | Kasai, K, Imamura, K, Narita, A, Makino, F, Miyata, T, Kato, T, Namba, K, Onishi, H, Tochio, H. | | Deposit date: | 2023-09-04 | | Release date: | 2024-09-04 | | Last modified: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | From Monomers to Oligomers: Structural Mechanism of Receptor-Triggered MyD88 Assembly in Innate Immune Signaling
Biorxiv, 2024
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2Z5V
 | | Solution structure of the TIR domain of human MyD88 | | Descriptor: | Myeloid differentiation primary response protein MyD88 | | Authors: | Ohnishi, H, Tochio, H, Hiroaki, H, Kondo, N, Kato, Z, Shirakawa, M. | | Deposit date: | 2007-07-19 | | Release date: | 2008-08-05 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling.
Proc.Natl.Acad.Sci.USA, 2009
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3MOP
 | | The ternary Death Domain complex of MyD88, IRAK4, and IRAK2 | | Descriptor: | Interleukin-1 receptor-associated kinase 4, Interleukin-1 receptor-associated kinase-like 2, Myeloid differentiation primary response protein MyD88 | | Authors: | Lin, S.-C, Lo, Y.-C, Wu, H. | | Deposit date: | 2010-04-23 | | Release date: | 2010-06-02 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.
Nature, 465, 2010
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9HGH
 | | MyD88 peptide_1 bound to SPOP MATH domain | | Descriptor: | Myeloid differentiation primary response protein MyD88, Speckle type BTB/POZ protein | | Authors: | Makhlouf, L, Zeqiraj, E. | | Deposit date: | 2024-11-19 | | Release date: | 2025-04-23 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Sequence rules for a long SPOP-binding degron required for protein ubiquitylation.
Biochem.J., 2025
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6I3N
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8S78
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7L6W
 | | SFX structure of the MyD88 TIR domain higher-order assembly | | Descriptor: | Myeloid differentiation primary response protein MyD88 | | Authors: | Clabbers, M.T.B, Holmes, S, Muusse, T.W, Vajjhala, P, Thygesen, S.J, Malde, A.K, Hunter, D.J.B, Croll, T.I, Flueckiger, L, Nanson, J.D, Rahaman, M.H, Aquila, A, Hunter, M.S, Liang, M, Yoon, C.H, Zhao, J, Zatsepin, N.A, Abbey, B, Sierecki, E, Gambin, Y, Stacey, K.J, Darmanin, C, Kobe, B, Xu, H, Ve, T. | | Deposit date: | 2020-12-24 | | Release date: | 2021-03-10 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.
Nat Commun, 12, 2021
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4DOM
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2JS7
 | | Solution NMR structure of human myeloid differentiation primary response (MyD88). Northeast Structural Genomics target HR2869A | | Descriptor: | Myeloid differentiation primary response protein MyD88 | | Authors: | Rossi, P, Ramelot, T.A, Tao, X, Ciano, M, Ho, C, Ma, L.-C, Xiao, R, Acton, T.B, Kennedy, M.A, Tong, L, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2007-06-29 | | Release date: | 2007-10-23 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | Solution NMR Structure of Human Myeloid Differentiation Primary Response (MyD88).
To be Published
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4EO7
 | | Crystal structure of the TIR domain of human myeloid differentiation primary response protein 88. | | Descriptor: | MAGNESIUM ION, Myeloid differentiation primary response protein MyD88 | | Authors: | Snyder, G.A, Cirl, C, Jiang, J.S, Chen, P, Smith, T, Xiao, T.S. | | Deposit date: | 2012-04-13 | | Release date: | 2013-04-10 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.449 Å) | | Cite: | Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli.
Proc.Natl.Acad.Sci.USA, 110, 2013
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7BER
 | | SFX structure of the MyD88 TIR domain higher-order assembly (solved, rebuilt and refined using an identical protocol to the MicroED structure of the MyD88 TIR domain higher-order assembly) | | Descriptor: | Myeloid differentiation primary response protein MyD88 | | Authors: | Clabbers, M.T.B, Holmes, S, Muusse, T.W, Vajjhala, P, Thygesen, S.J, Malde, A.K, Hunter, D.J.B, Croll, T.I, Nanson, J.D, Rahaman, M.H, Aquila, A, Hunter, M.S, Liang, M, Yoon, C.H, Zhao, J, Zatsepin, N.A, Abbey, B, Sierecki, E, Gambin, Y, Darmanin, C, Kobe, B, Xu, H, Ve, T. | | Deposit date: | 2020-12-24 | | Release date: | 2021-03-10 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.
Nat Commun, 12, 2021
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7BEQ
 | | MicroED structure of the MyD88 TIR domain higher-order assembly | | Descriptor: | Myeloid differentiation primary response protein MyD88 | | Authors: | Clabbers, M.T.B, Holmes, S, Muusse, T.W, Vajjhala, P, Thygesen, S.J, Malde, A.K, Hunter, D.J.B, Croll, T.I, Nanson, J.D, Rahaman, M.H, Aquila, A, Hunter, M.S, Liang, M, Yoon, C.H, Zhao, J, Zatsepin, N.A, Abbey, B, Sierecki, E, Gambin, Y, Darmanin, C, Kobe, B, Xu, H, Ve, T. | | Deposit date: | 2020-12-24 | | Release date: | 2021-03-10 | | Last modified: | 2024-01-31 | | Method: | ELECTRON CRYSTALLOGRAPHY (3 Å) | | Cite: | MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.
Nat Commun, 12, 2021
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