7L6W

SFX structure of the MyD88 TIR domain higher-order assembly

Summary for 7L6W

Entry DOI	10.2210/pdb7l6w/pdb
Descriptor	Myeloid differentiation primary response protein MyD88 (2 entities in total)
Functional Keywords	sfx, serial femtosecond crystallography, myd88, tir domain, higher-order assembly, protein binding
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	16207.99
Authors	Clabbers, M.T.B.,Holmes, S.,Muusse, T.W.,Vajjhala, P.,Thygesen, S.J.,Malde, A.K.,Hunter, D.J.B.,Croll, T.I.,Flueckiger, L.,Nanson, J.D.,Rahaman, M.H.,Aquila, A.,Hunter, M.S.,Liang, M.,Yoon, C.H.,Zhao, J.,Zatsepin, N.A.,Abbey, B.,Sierecki, E.,Gambin, Y.,Stacey, K.J.,Darmanin, C.,Kobe, B.,Xu, H.,Ve, T. (deposition date: 2020-12-24, release date: 2021-03-10, Last modification date: 2023-10-18)
Primary citation	Clabbers, M.T.B.,Holmes, S.,Muusse, T.W.,Vajjhala, P.R.,Thygesen, S.J.,Malde, A.K.,Hunter, D.J.B.,Croll, T.I.,Flueckiger, L.,Nanson, J.D.,Rahaman, M.H.,Aquila, A.,Hunter, M.S.,Liang, M.,Yoon, C.H.,Zhao, J.,Zatsepin, N.A.,Abbey, B.,Sierecki, E.,Gambin, Y.,Stacey, K.J.,Darmanin, C.,Kobe, B.,Xu, H.,Ve, T. MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography. Nat Commun, 12:2578-2578, 2021 Cited by PubMed: 33972532 DOI: 10.1038/s41467-021-22590-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation