4DOM

Crystal Structure of the TIR-domain of Human Myeloid Differentiation Primary Response protein (MyD88)

Summary for 4DOM

Entry DOI	10.2210/pdb4dom/pdb
Descriptor	Myeloid differentiation primary response protein MyD88 (2 entities in total)
Functional Keywords	myd88_human, tir-domain, toll-like receptor, adopter domain, innate immune signaling, tirap/mal, signaling protein, lysine methylation
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	16718.62
Authors	Jiang, J.S.,Snyder, G.A.,Xiao, T. (deposition date: 2012-02-09, release date: 2013-04-10, Last modification date: 2023-12-06)
Primary citation	Snyder, G.A.,Cirl, C.,Jiang, J.,Chen, K.,Waldhuber, A.,Smith, P.,Rommler, F.,Snyder, N.,Fresquez, T.,Durr, S.,Tjandra, N.,Miethke, T.,Xiao, T.S. Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli. Proc.Natl.Acad.Sci.USA, 110:6985-6990, 2013 Cited by PubMed: 23569230 DOI: 10.1073/pnas.1215770110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.798 Å)

Structure validation