8QEL
 
 | | PKR kinase domain- eIF2alpha in complex with compound | | Descriptor: | (3~{Z})-3-[(4-methyl-1~{H}-imidazol-5-yl)methylidene]-2-oxidanylidene-1~{H}-indole-5-carboxamide, Eukaryotic translation initiation factor 2 subunit alpha, Interferon-induced, ... | | Authors: | Nawrotek, A, Vuillard, L, Miallau, L. | | Deposit date: | 2023-08-31 | | Release date: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.451 Å) | | Cite: | PKR kinase domain- eIF2alpha in complex with compound
To Be Published
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2A19
 | | PKR kinase domain- eIF2alpha- AMP-PNP complex. | | Descriptor: | Eukaryotic translation initiation factor 2 alpha subunit, Interferon-induced, double-stranded RNA-activated protein kinase, ... | | Authors: | Dar, A.C, Dever, T.E, Sicheri, F. | | Deposit date: | 2005-06-19 | | Release date: | 2005-09-27 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Higher-Order Substrate Recognition of eIF2alpha by the RNA-Dependent Protein Kinase PKR.
Cell(Cambridge,Mass.), 122, 2005
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2A1A
 | | PKR kinase domain-eIF2alpha Complex | | Descriptor: | Eukaryotic translation initiation factor 2 alpha subunit, Interferon-induced, double-stranded RNA-activated protein kinase | | Authors: | Dar, A.C, Dever, T.E, Sicheri, F. | | Deposit date: | 2005-06-19 | | Release date: | 2005-09-27 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Higher-Order Substrate Recognition of eIF2alpha by the RNA-Dependent Protein Kinase PKR.
Cell(Cambridge,Mass.), 122, 2005
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1Q46
 | | crystal structure of the eIF2 alpha subunit from saccharomyces cerevisia | | Descriptor: | translation initiation factor 2 alpha subunit | | Authors: | Dhaliwal, S, Hoffman, D.W. | | Deposit date: | 2003-08-01 | | Release date: | 2003-10-28 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.86 Å) | | Cite: | The crystal structure of the N-terminal region of the alpha subunit of translation initiation factor 2 (eIF2alpha) from Saccharomyces cerevisiae provides a view of the loop containing serine 51, the target of the eIF2alpha-specific kinases.
J.Mol.Biol., 334, 2003
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6FYY
 | | Structure of a partial yeast 48S preinitiation complex with eIF5 N-terminal domain (model C2) | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S0, 40S ribosomal protein S1, ... | | Authors: | Llacer, J.L, Hussain, T, Gordiyenko, Y, Ramakrishnan, V. | | Deposit date: | 2018-03-12 | | Release date: | 2018-12-05 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition.
Elife, 7, 2018
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8CAS
 | | Cryo-EM structure of native Otu2-bound ubiquitinated 48S initiation complex (partial) | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | | Authors: | Ikeuchi, K, Buschauer, R, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | | Deposit date: | 2023-01-24 | | Release date: | 2023-05-24 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2.
Nat Commun, 14, 2023
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6JLZ
 | | P-eIF2a - eIF2B complex | | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, PHOSPHATE ION, Probable translation initiation factor eIF-2B subunit beta, ... | | Authors: | Kashiwagi, K, Ito, T. | | Deposit date: | 2019-03-07 | | Release date: | 2019-05-01 | | Last modified: | 2019-05-15 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Structural basis for eIF2B inhibition in integrated stress response.
Science, 364, 2019
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6JLY
 | | eIF2a - eIF2B complex | | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, PHOSPHATE ION, Probable translation initiation factor eIF-2B subunit beta, ... | | Authors: | Kashiwagi, K, Ito, T. | | Deposit date: | 2019-03-07 | | Release date: | 2019-05-01 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structural basis for eIF2B inhibition in integrated stress response.
Science, 364, 2019
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6FYX
 | | Structure of a partial yeast 48S preinitiation complex with eIF5 N-terminal domain (model C1) | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S0, 40S ribosomal protein S1, ... | | Authors: | Llacer, J.L, Hussain, T, Gordiyenko, Y, Ramakrishnan, V. | | Deposit date: | 2018-03-12 | | Release date: | 2018-12-05 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition.
Elife, 7, 2018
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6I3M
 | | eIF2B:eIF2 complex, phosphorylated on eIF2 alpha serine 52. | | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | | Authors: | Adomavicius, T, Roseman, A.M, Pavitt, G.D. | | Deposit date: | 2018-11-06 | | Release date: | 2019-05-22 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (3.93 Å) | | Cite: | The structural basis of translational control by eIF2 phosphorylation.
Nat Commun, 10, 2019
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3J81
 | | CryoEM structure of a partial yeast 48S preinitiation complex | | Descriptor: | 18S rRNA, MAGNESIUM ION, METHIONINE, ... | | Authors: | Hussain, T, Llacer, J.L, Fernandez, I.S, Savva, C.G, Ramakrishnan, V. | | Deposit date: | 2014-08-29 | | Release date: | 2014-11-05 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structural changes enable start codon recognition by the eukaryotic translation initiation complex.
Cell(Cambridge,Mass.), 159, 2014
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6QG1
 | | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model 2) | | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | | Authors: | Llacer, J.L, Gordiyenko, Y, Ramakrishnan, V. | | Deposit date: | 2019-01-10 | | Release date: | 2019-06-26 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structural basis for the inhibition of translation through eIF2 alpha phosphorylation.
Nat Commun, 10, 2019
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6QG0
 | | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model 1) | | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | | Authors: | Llacer, J.L, Gordiyenko, Y, Ramakrishnan, V. | | Deposit date: | 2019-01-10 | | Release date: | 2019-06-26 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structural basis for the inhibition of translation through eIF2 alpha phosphorylation.
Nat Commun, 10, 2019
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6QG2
 | | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model A) | | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | | Authors: | Llacer, J.L, Gordiyenko, Y, Ramakrishnan, V. | | Deposit date: | 2019-01-10 | | Release date: | 2019-06-26 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structural basis for the inhibition of translation through eIF2 alpha phosphorylation.
Nat Commun, 10, 2019
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6I7T
 | | eIF2B:eIF2 complex | | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | | Authors: | Adomavicius, T, Guaita, M, Roseman, A.M, Pavitt, G.D. | | Deposit date: | 2018-11-17 | | Release date: | 2019-05-22 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.61 Å) | | Cite: | The structural basis of translational control by eIF2 phosphorylation.
Nat Commun, 10, 2019
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6QG6
 | | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model D) | | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | | Authors: | Llacer, J.L, Gordiyenko, Y, Ramakrishnan, V. | | Deposit date: | 2019-01-10 | | Release date: | 2019-06-26 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (4.65 Å) | | Cite: | Structural basis for the inhibition of translation through eIF2 alpha phosphorylation.
Nat Commun, 10, 2019
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3JAP
 | | Structure of a partial yeast 48S preinitiation complex in closed conformation | | Descriptor: | 18S rRNA, MAGNESIUM ION, METHIONINE, ... | | Authors: | Llacer, J.L, Hussain, T, Ramakrishnan, V. | | Deposit date: | 2015-06-18 | | Release date: | 2015-08-12 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (4.9 Å) | | Cite: | Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex.
Mol.Cell, 59, 2015
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6GSM
 | | Structure of a partial yeast 48S preinitiation complex in open conformation. | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S0, 40S ribosomal protein S1, ... | | Authors: | Llacer, J.L, Hussain, T, Gordiyenko, Y, Ramakrishnan, V. | | Deposit date: | 2018-06-14 | | Release date: | 2019-07-31 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (5.15 Å) | | Cite: | Large-scale movement of eIF3 domains during translation initiation modulate start codon selection.
Nucleic Acids Res., 2021
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6GSN
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6QG3
 | | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model B) | | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | | Authors: | Llacer, J.L, Gordiyenko, Y, Ramakrishnan, V. | | Deposit date: | 2019-01-10 | | Release date: | 2019-06-26 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (9.4 Å) | | Cite: | Structural basis for the inhibition of translation through eIF2 alpha phosphorylation.
Nat Commun, 10, 2019
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6QG5
 | | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model C) | | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | | Authors: | Llacer, J.L, Gordiyenko, Y, Ramakrishnan, V. | | Deposit date: | 2019-01-10 | | Release date: | 2019-06-26 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (10.1 Å) | | Cite: | Structural basis for the inhibition of translation through eIF2 alpha phosphorylation.
Nat Commun, 10, 2019
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