Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model D)

Summary for 6QG6

Related6QG0 6QG1 6QG2 6QG3 6QG5
EMDB information4543 4544 4545 4546 4547 4548
DescriptorTranslation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit gamma, ... (8 entities in total)
Functional Keywordsintegrated stress response, isr, translation, initiation factors, phosphorylation, eif2, eif2b, trnai, gef, heat domain, eif2 alpha
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
Total number of polymer chains16
Total molecular weight838127.37
Llacer, J.L.,Gordiyenko, Y.,Ramakrishnan, V. (deposition date: 2019-01-10, release date: 2019-06-26, Last modification date: 2019-08-21)
Primary citation
Gordiyenko, Y.,Llacer, J.L.,Ramakrishnan, V.
Structural basis for the inhibition of translation through eIF2 alpha phosphorylation.
Nat Commun, 10:2640-2640, 2019
PubMed: 31201334 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-019-10606-1
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers7 3.0% 9.3%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation report