2H62
 
 | | Crystal structure of a ternary ligand-receptor complex of BMP-2 | | Descriptor: | Acvr2b protein, Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA | | Authors: | Mueller, T.D. | | Deposit date: | 2006-05-30 | | Release date: | 2007-04-10 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.
Bmc Struct.Biol., 7, 2007
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1REW
 | | Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor | | Descriptor: | bone morphogenetic protein 2, bone morphogenetic protein receptor type IA | | Authors: | Keller, S, Nickel, J, Zhang, J.-L, Sebald, W, Mueller, T.D. | | Deposit date: | 2003-11-07 | | Release date: | 2004-05-04 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.863 Å) | | Cite: | Molecular recognition of BMP-2 and BMP receptor IA.
Nat.Struct.Mol.Biol., 11, 2004
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4N1D
 | | Nodal/BMP2 chimera NB250 | | Descriptor: | Nodal/BMP2 chimera protein | | Authors: | Esquivies, L. | | Deposit date: | 2013-10-04 | | Release date: | 2013-12-04 | | Last modified: | 2017-07-26 | | Method: | X-RAY DIFFRACTION (1.912 Å) | | Cite: | Designer Nodal/BMP2 Chimeras Mimic Nodal Signaling, Promote Chondrogenesis, and Reveal a BMP2-like Structure.
J.Biol.Chem., 289, 2014
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2H64
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4MID
 | | Crystal Structure of Activin A/BMP2 chimera | | Descriptor: | AB204 Activin A/BMP2 chimera | | Authors: | Esquivies, L. | | Deposit date: | 2013-08-30 | | Release date: | 2014-05-07 | | Last modified: | 2019-07-17 | | Method: | X-RAY DIFFRACTION (2.139 Å) | | Cite: | An Activin A/BMP2 Chimera, AB204, Displays Bone-Healing Properties Superior to Those of BMP2.
J.Bone Miner.Res., 29, 2014
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2GOO
 | | Ternary Complex of BMP-2 bound to BMPR-Ia-ECD and ActRII-ECD | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, Activin receptor type 2A, Bone morphogenetic protein 2, ... | | Authors: | Allendorph, G.P, Choe, S. | | Deposit date: | 2006-04-13 | | Release date: | 2006-05-09 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of the ternary signaling complex of a TGF-beta superfamily member.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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4UI1
 | | Crystal structure of the human RGMC-BMP2 complex | | Descriptor: | 1,2-ETHANEDIOL, BONE MORPHOGENETIC PROTEIN 2, CHLORIDE ION, ... | | Authors: | Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C. | | Deposit date: | 2015-03-27 | | Release date: | 2015-05-06 | | Last modified: | 2015-06-17 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein.
Nat.Struct.Mol.Biol., 22, 2015
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2QJ9
 | | Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B1 | | Descriptor: | Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA | | Authors: | Kotzsch, A, Mueller, T.D. | | Deposit date: | 2007-07-06 | | Release date: | 2008-01-15 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome.
J.Biol.Chem., 283, 2008
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2QJB
 | | Crystal structure analysis of BMP-2 in complex with BMPR-IA variant IA/IB | | Descriptor: | Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA, CHLORIDE ION | | Authors: | Kotzsch, A, Mueller, T.D. | | Deposit date: | 2007-07-06 | | Release date: | 2008-01-15 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome.
J.Biol.Chem., 283, 2008
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2QJA
 | | Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B12 | | Descriptor: | Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA | | Authors: | Kotzsch, A, Mueller, T.D. | | Deposit date: | 2007-07-06 | | Release date: | 2008-01-15 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome.
J.Biol.Chem., 283, 2008
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1REU
 | | Structure of the bone morphogenetic protein 2 mutant L51P | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, bone morphogenetic protein 2 | | Authors: | Keller, S, Nickel, J, Zhang, J.-L, Sebald, W, Mueller, T.D. | | Deposit date: | 2003-11-07 | | Release date: | 2004-05-04 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Molecular recognition of BMP-2 and BMP receptor IA.
Nat.Struct.Mol.Biol., 11, 2004
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6OMN
 | | Glycosylated BMP2 homodimer | | Descriptor: | Bone morphogenetic protein 2, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Juo, Z.S, Seeherman, H. | | Deposit date: | 2019-04-19 | | Release date: | 2019-05-08 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix.
Sci Transl Med, 11, 2019
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3BMP
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3BK3
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8E3G
 | | BMP2/GDF5 heterodimer | | Descriptor: | Bone morphogenetic protein 2, GLYCEROL, Growth/differentiation factor 5 | | Authors: | Gipson, G.R, Nolan, K.T, Thompson, T.B. | | Deposit date: | 2022-08-17 | | Release date: | 2023-02-15 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers.
Bmc Biol., 21, 2023
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4UI0
 | | Crystal structure of the human RGMB-BMP2 complex, crystal form 2 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, BONE MORPHOGENETIC PROTEIN 2, CHLORIDE ION, ... | | Authors: | Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C. | | Deposit date: | 2015-03-27 | | Release date: | 2015-05-06 | | Last modified: | 2015-06-17 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein.
Nat.Struct.Mol.Biol., 22, 2015
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4UHZ
 | | Crystal structure of the human RGMB-BMP2 complex, crystal form 1 | | Descriptor: | BONE MORPHOGENETIC PROTEIN 2, RGM DOMAIN FAMILY MEMBER B, SULFATE ION | | Authors: | Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C. | | Deposit date: | 2015-03-27 | | Release date: | 2015-05-06 | | Last modified: | 2015-06-17 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein.
Nat.Struct.Mol.Biol., 22, 2015
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1ES7
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7AG0
 | | Complex between the bone morphogenetic protein 2 and its antagonist Noggin | | Descriptor: | Bone morphogenetic protein 2, GLYCEROL, Noggin | | Authors: | Robert, C, Bruck, F, Herman, R, Vandevenne, M, Filee, P, Kerff, F, Matagne, A. | | Deposit date: | 2020-09-21 | | Release date: | 2022-04-13 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3.104 Å) | | Cite: | Structural analysis of the interaction between human cytokine BMP-2 and the antagonist Noggin reveals molecular details of cell chondrogenesis inhibition.
J.Biol.Chem., 299, 2023
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4UI2
 | | Crystal structure of the ternary RGMB-BMP2-NEO1 complex | | Descriptor: | ACETATE ION, BONE MORPHOGENETIC PROTEIN 2, BMP2, ... | | Authors: | Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C. | | Deposit date: | 2015-03-27 | | Release date: | 2015-05-06 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein.
Nat.Struct.Mol.Biol., 22, 2015
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4UHY
 | | Crystal structure of the human RGMA-BMP2 complex | | Descriptor: | BONE MORPHOGENETIC PROTEIN 2, REPULSIVE GUIDANCE MOLECULE A | | Authors: | Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C. | | Deposit date: | 2015-03-27 | | Release date: | 2015-05-06 | | Last modified: | 2015-06-17 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein.
Nat.Struct.Mol.Biol., 22, 2015
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