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PDB: 216 results

2FMA
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Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, atomic resolution
Descriptor: Amyloid beta A4 protein precursor, GLYCEROL
Authors:Kong, G.K.-W.
Deposit date:2006-01-08
Release date:2007-01-16
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (0.85 Å)
Cite:Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution.
Acta Crystallogr.,Sect.F, 63, 2007
6NB9
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Amyloid-Beta (20-34) with L-isoaspartate 23
Descriptor: Amyloid-beta A4 protein
Authors:Sawaya, M.R, Warmack, R.A, Boyer, D.R, Zee, C.T, Richards, L.S, Cascio, D, Gonen, T, Clarke, S.G, Eisenberg, D.S.
Deposit date:2018-12-06
Release date:2019-08-07
Last modified:2022-09-07
Method:ELECTRON CRYSTALLOGRAPHY (1.05 Å)
Cite:Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.
Nat Commun, 10, 2019
8T82
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Racemic mixture of amyloid beta segment 35-MVGGVV-40 forms heterochiral rippled beta-sheet, includes pentafluoropropionic acid
Descriptor: amyloid beta segment 35-MVGGVV-40, racemic mixture, pentafluoropropanoic acid
Authors:Sawaya, M.R, Raskatov, J.A, Hazari, A.
Deposit date:2023-06-21
Release date:2023-11-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Racemic Peptides from Amyloid beta and Amylin Form Rippled beta-Sheets Rather Than Pleated beta-Sheets.
J.Am.Chem.Soc., 145, 2023
6OIZ
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Amyloid-Beta (20-34) wild type
Descriptor: Amyloid beta A4 protein
Authors:Sawaya, M.R, Warmack, R.A, Zee, C.T, Gonen, T, Clarke, S.G, Eisenberg, D.S.
Deposit date:2019-04-10
Release date:2019-08-07
Last modified:2024-05-15
Method:ELECTRON CRYSTALLOGRAPHY (1.1 Å)
Cite:Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.
Nat Commun, 10, 2019
5ONQ
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Alzheimer's Amyloid-Beta Peptide Fragment 29-40 in Complex with Cd-substituted Thermolysin
Descriptor: Amyloid-beta A4 protein, CADMIUM ION, CALCIUM ION, ...
Authors:Leite, J.P, Gales, L.
Deposit date:2017-08-04
Release date:2018-08-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett., 593, 2019
3JQL
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Crystal Structure of the Complex Formed Between Phospholipase A2 and a Hexapeptide Fragment of Amyloid Beta Peptide, Lys-Leu-Val-Phe-Phe-Ala at 1.2 A Resolution
Descriptor: Acidic phospholipase A2 3 (Fragment), Amyloid Beta Peptide, CALCIUM ION
Authors:Mirza, Z, Vikram, G, Singh, N, Sinha, M, Sharma, S, Srinivasan, A, Kaur, P, Singh, T.P.
Deposit date:2009-09-07
Release date:2009-09-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal Structure of the Complex Formed Between Phospholipase A2 and a Hexapeptide Fragment of Amyloid Beta Peptide, Lys-Leu-Val-Phe-Phe-Ala at 1.2 A Resolution
To be Published
3PZZ
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Structure of an amyloid forming peptide GAIIGL (29-34) from amyloid beta
Descriptor: Amyloid beta A4 protein
Authors:Soriaga, A.B, Laganowsky, A.L, Sawaya, M.R, Eisenberg, D.
Deposit date:2010-12-14
Release date:2011-10-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Molecular basis for amyloid-beta polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
4PQD
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The longer crystal structure of the grow factor like domain from Beta amypoid precusor protein (APP22-126)
Descriptor: Amyloid beta A4 protein
Authors:Tan, X, Li, W, Wang, Z.
Deposit date:2014-03-02
Release date:2015-04-08
Method:X-RAY DIFFRACTION (1.332 Å)
Cite:Mapping the interaction betwwen APP and DR6
To be Published
5ONP
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Alzheimer's Amyloid-Beta Peptide Fragment 1-40 in Complex with Cd-substituted Thermolysin
Descriptor: Amyloid-beta A4 protein, CADMIUM ION, CALCIUM ION, ...
Authors:Leite, J.P, Gales, L.
Deposit date:2017-08-04
Release date:2018-08-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett., 593, 2019
5ONR
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Alzheimer's Amyloid-Beta Peptide Fragment 1-40 in Complex with Thermolysin
Descriptor: Amyloid-beta A4 protein, CALCIUM ION, DIMETHYL SULFOXIDE, ...
Authors:Leite, J.P, Gales, L.
Deposit date:2017-08-04
Release date:2018-08-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett., 593, 2019
4PWQ
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HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE E1-DOMAIN of THE AMYLOID PRECURSOR PROTEIN
Descriptor: Amyloid beta A4 protein
Authors:Hoefgen, S, Dahms, S.O, Than, M.E.
Deposit date:2014-03-21
Release date:2015-02-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Amyloid Precursor Protein Shows a pH-Dependent Conformational Switch in Its E1 Domain.
J.Mol.Biol., 427, 2015
7OW1
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BU of 7ow1 by Molmil
Crystal Structure of TAP01 in complex with amyloid beta peptide
Descriptor: Amyloid-beta precursor protein, CITRATE ANION, TAP01 family antibody heavy chain, ...
Authors:Hall, G, Cowan, R, Carr, M.D.
Deposit date:2021-06-16
Release date:2022-06-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Discovery of a novel pseudo beta-hairpin structure of N-truncated amyloid-beta for use as a vaccine against Alzheimer's disease.
Mol Psychiatry, 27, 2022
6O4J
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BU of 6o4j by Molmil
Amyloid Beta KLVFFAENVGS 16-26 D23N Iowa mutation
Descriptor: Amyloid-beta precursor protein
Authors:Griner, S.L, Sawaya, M.R, Rodriguez, J.A, Cascio, D, Gonen, T.
Deposit date:2019-02-28
Release date:2019-10-30
Last modified:2023-10-11
Method:ELECTRON CRYSTALLOGRAPHY (1.402 Å)
Cite:Structure based inhibitors of Amyloid Beta core suggest a common interface with Tau.
Elife, 8, 2019
5VOS
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BU of 5vos by Molmil
VGSNKGAIIGL from Amyloid Beta determined by MicroED
Descriptor: Amyloid beta A4 protein
Authors:Rodriguez, J.A, Sawaya, M.R, Cascio, D, Eisenberg, D.S, Griner, S.L, Gonen, T.
Deposit date:2017-05-03
Release date:2018-01-03
Last modified:2024-03-13
Method:ELECTRON CRYSTALLOGRAPHY (1.42 Å)
Cite:Common fibrillar spines of amyloid-beta and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.
J. Biol. Chem., 293, 2018
3Q2X
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Structure of an amyloid forming peptide NKGAII (residues 27-32) from amyloid beta
Descriptor: Amyloid beta A4 protein
Authors:Soriaga, A.B, Sawaya, M.R, Eisenberg, D.
Deposit date:2010-12-20
Release date:2011-10-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.451 Å)
Cite:Molecular basis for amyloid-beta polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
5TXD
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BU of 5txd by Molmil
Structure of amyloid-beta derived peptide - NKGAIF
Descriptor: Amyloid beta A4 protein, PHOSPHATE ION
Authors:Sangwan, S, Sawaya, M.R, Eisenberg, D.
Deposit date:2016-11-16
Release date:2017-11-15
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.452 Å)
Cite:Distal amyloid beta-protein fragments template amyloid assembly.
Protein Sci., 27, 2018
5MYX
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BU of 5myx by Molmil
Structure of Pyroglutamate-Abeta-specific Fab c#24 in complex with human Abeta-pE3-18
Descriptor: Fab c#24 heavy chain, Fab c#24 light chain, Pyroglutamate-Abeta pE3-18
Authors:Parthier, C, Piechotta, A, Stubbs, M.T.
Deposit date:2017-01-30
Release date:2017-06-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.492 Å)
Cite:Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
J. Biol. Chem., 292, 2017
4MVK
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BU of 4mvk by Molmil
Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide fragment VFFAED
Descriptor: Amyloid peptide fragment VFFAED, Neutrophil gelatinase-associated lipocalin
Authors:Eichinger, A, Skerra, A.
Deposit date:2013-09-24
Release date:2015-08-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
Biochem.J., 473, 2016
8T89
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BU of 8t89 by Molmil
Racemic mixture of amyloid beta segment 16-KLVFFA-21 forms heterochiral rippled beta-sheet
Descriptor: Racemic mixture of amyloid beta segment 16-KLVFFA-21, trifluoroacetic acid
Authors:Sawaya, M.R, Raskatov, J.A, Hazari, A.
Deposit date:2023-06-22
Release date:2023-11-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Racemic Peptides from Amyloid beta and Amylin Form Rippled beta-Sheets Rather Than Pleated beta-Sheets.
J.Am.Chem.Soc., 145, 2023
3IFN
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BU of 3ifn by Molmil
X-ray structure of amyloid beta peptide:antibody (Abeta1-40:12A11) complex
Descriptor: 12A11 FAB antibody heavy chain, 12A11 FAB antibody light chain, Amyloid beta A4 protein
Authors:Weis, W.I, Feinberg, H, Basi, G.S, Schenk, D.
Deposit date:2009-07-24
Release date:2009-11-17
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
J.Biol.Chem., 285, 2010
3IFL
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BU of 3ifl by Molmil
X-ray structure of amyloid beta peptide:antibody (Abeta1-7:12A11) complex
Descriptor: 12A11 FAB antibody heavy chain, 12A11 FAB antibody light chain, Amyloid beta A4 protein
Authors:Weis, W.I, Feinberg, H, Basi, G.S, Schenk, D.
Deposit date:2009-07-24
Release date:2009-11-17
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
J.Biol.Chem., 285, 2010
1AAP
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BU of 1aap by Molmil
X-RAY CRYSTAL STRUCTURE OF THE PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR
Descriptor: ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN
Authors:Hynes, T.R, Randal, M, Kennedy, L.A, Eigenbrot, C, Kossiakoff, A.A.
Deposit date:1990-09-14
Release date:1991-10-15
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.
Biochemistry, 29, 1990
5AMB
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BU of 5amb by Molmil
Crystal structure of the Angiotensin-1 converting enzyme N-domain in complex with amyloid-beta 35-42
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AMYLOID BETA A4 PROTEIN, ANGIOTENSIN-CONVERTING ENZYME, ...
Authors:Masuyer, G, Larmuth, K.M, Douglas, R.G, Sturrock, E.D, Acharya, K.R.
Deposit date:2015-03-10
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:The Kinetic and Structural Characterisation of Amyloid-Beta Metabolism by Human Angiotensin-1- Converting Enzyme (Ace)
FEBS J., 283, 2016
3BKJ
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Crystal structure of Fab wo2 bound to the n terminal domain of amyloid beta peptide (1-16)
Descriptor: Amyloid Beta Peptide, WO2 IgG2a Fab fragment Heavy Chain, WO2 IgG2a Fab fragment Light Chain Kappa
Authors:Miles, L.A, Wun, K.S, Crespi, G.A, Fodero-Tavoletti, M, Galatis, D, Bageley, C.J, Beyreuther, K, Masters, C.L, Cappai, R, McKinstry, W.J, Barnham, K.J, Parker, M.W.
Deposit date:2007-12-06
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope.
J.Mol.Biol., 377, 2008
5MYO
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Structure of Pyroglutamate-Abeta-specific Fab c#6 in complex with human Abeta-pE3-12-PEGb
Descriptor: Amyloid beta A4 protein, Fab c#6 heavy chain, Fab c#6 light chain, ...
Authors:Parthier, C, Piechotta, A, Stubbs, M.T.
Deposit date:2017-01-27
Release date:2017-06-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
J. Biol. Chem., 292, 2017

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