Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 413 results

1F86
DownloadVisualize
BU of 1f86 by Molmil
TRANSTHYRETIN THR119MET PROTEIN STABILISATION
Descriptor: 3,5,3',5'-TETRAIODO-L-THYRONINE, TRANSTHYRETIN THR119MET VARIANT
Authors:Sebastiao, M.P.
Deposit date:2000-06-29
Release date:2001-06-29
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Transthyretin stability as a key factor in amyloidogenesis: X-ray analysis at atomic resolution.
J.Mol.Biol., 306, 2001
8C86
DownloadVisualize
BU of 8c86 by Molmil
Crystal structure of human transthyretin in complex with 3-O-methyltolcapone analogue 2
Descriptor: (2,4-dimethylphenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin
Authors:Poonsiri, T, Benini, S, Loconte, V, Cianci, M.
Deposit date:2023-01-18
Release date:2024-01-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:3-O-Methyltolcapone and Its Lipophilic Analogues Are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity.
Int J Mol Sci, 25, 2023
8W45
DownloadVisualize
BU of 8w45 by Molmil
X-ray crystal structure of V30M-TTR in complex with pinostilbene
Descriptor: 3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxy-phenol, SODIUM ION, Transthyretin
Authors:Yokoyama, T.
Deposit date:2023-08-23
Release date:2023-11-22
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin.
J.Med.Chem., 66, 2023
4QXV
DownloadVisualize
BU of 4qxv by Molmil
CRYSTAL STRUCTURE of HUMAN TRANSTHYRETIN IN COMPLEX WITH LUTEOLIN AT 1.1 A RESOLUTION
Descriptor: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, GLYCEROL, SODIUM ION, ...
Authors:Begum, A, Olofsson, A, Sauer-Eriksson, A.E.
Deposit date:2014-07-22
Release date:2015-06-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response.
Plos One, 10, 2015
4KY2
DownloadVisualize
BU of 4ky2 by Molmil
Transthyretin in complex with the fluorescent folding sensor (E)-7-hydroxy-3-(4-hydroxy-3,5-dimethylstyryl)-4-methyl-2H-chromen-2-one
Descriptor: 7-hydroxy-3-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]-4-methyl-2H-chromen-2-one, Transthyretin
Authors:Connelly, S, Wilson, I.A, Choi, S.
Deposit date:2013-05-28
Release date:2013-08-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors.
Chem.Commun.(Camb.), 49, 2013
7EJQ
DownloadVisualize
BU of 7ejq by Molmil
Crystal structure of human transthyretin in complex with 8-chloro-9-oxo-9H-xanthene-3-carboxylic acid
Descriptor: 8-chloranyl-9-oxidanylidene-xanthene-3-carboxylic acid, CALCIUM ION, Transthyretin
Authors:Kitakami, R, Yokoyama, T, Mizuguchi, M.
Deposit date:2021-04-02
Release date:2021-10-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis.
Bioorg.Med.Chem., 44, 2021
8AWI
DownloadVisualize
BU of 8awi by Molmil
Crystal structure of Human Transthyretin at 1.15 Angstrom resolution
Descriptor: SODIUM ION, Transthyretin
Authors:Derbyshire, D.J, Hammarstrom, P, von Castelmur, E, Begum, A.
Deposit date:2022-08-29
Release date:2023-03-01
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Transthyretin Binding Mode Dichotomy of Fluorescent trans -Stilbene Ligands.
Acs Chem Neurosci, 14, 2023
4D7B
DownloadVisualize
BU of 4d7b by Molmil
Structure of human transthyretin in complex with Tolcapone
Descriptor: TRANSTHYRETIN, Tolcapone
Authors:Gallego, P, Sant'anna, R.O, Ventura, S, Reverter, D.
Deposit date:2014-11-21
Release date:2016-01-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Repositioning Tolcapone as a Potent Inhibitor of Transthyretin Amyloidogenesis and its Associated Cellular Toxicity
Nat.Commun., 7, 2016
6TXW
DownloadVisualize
BU of 6txw by Molmil
V30G Transthyretin structure in complex with Tolcalpone
Descriptor: Tolcapone, Transthyretin
Authors:Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S.
Deposit date:2020-01-14
Release date:2020-05-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.153 Å)
Cite:Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis.
Febs J., 288, 2021
4L1T
DownloadVisualize
BU of 4l1t by Molmil
Transthyretin in complex with (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzoic acid
Descriptor: 3-(dimethylamino)-5-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid, Transthyretin
Authors:Connelly, S, Wilson, I.A.
Deposit date:2013-06-03
Release date:2013-10-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learn.
Biopolymers, 101, 2014
4HIQ
DownloadVisualize
BU of 4hiq by Molmil
The Structure of V122I Mutant Transthyretin in Complex with AG10
Descriptor: 3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluorobenzoic acid, Transthyretin
Authors:Connelly, S, Alhamadsheh, M, Graef, I, Wilson, I.A.
Deposit date:2012-10-11
Release date:2013-06-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin.
Proc.Natl.Acad.Sci.USA, 110, 2013
8W48
DownloadVisualize
BU of 8w48 by Molmil
Neutron and X-ray joint structure of WT-TTR in complex with piceatannol
Descriptor: PICEATANNOL, Transthyretin
Authors:Yokoyama, T, Kusaka, K, Fujiwara, S.
Deposit date:2023-08-23
Release date:2023-11-22
Last modified:2023-12-06
Method:NEUTRON DIFFRACTION (1.19 Å), X-RAY DIFFRACTION
Cite:Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin.
J.Med.Chem., 66, 2023
8C85
DownloadVisualize
BU of 8c85 by Molmil
Crystal structure of human transthyretin in complex with 3-O-methyltolcapone analogue 1
Descriptor: (3,5-dimethylphenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin
Authors:Poonsiri, T, Benini, S, Loconte, V, Cianci, M.
Deposit date:2023-01-18
Release date:2024-01-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:3-O-Methyltolcapone and Its Lipophilic Analogues Are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity.
Int J Mol Sci, 25, 2023
7DT3
DownloadVisualize
BU of 7dt3 by Molmil
Crystal structure of human transthyretin in complex with 4-chloro-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
Descriptor: 4-chloranyl-9,10-bis(oxidanylidene)anthracene-2-carboxylic acid, CALCIUM ION, Transthyretin
Authors:Kitakami, R, Yokoyama, T, Mizuguchi, M.
Deposit date:2021-01-04
Release date:2021-10-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.198 Å)
Cite:Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis.
Bioorg.Med.Chem., 44, 2021
5FW7
DownloadVisualize
BU of 5fw7 by Molmil
Structure of human transthyretin mutant A109V
Descriptor: TRANSTHYRETIN
Authors:Gallego, P, Varejao, N, Santanna, R, Saraiva, M.J, Ventura, S, Reverter, D.
Deposit date:2016-02-12
Release date:2017-03-08
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure of New Non-Amyloidogenic Mutant of Ttr A108V
To be Published
7QC5
DownloadVisualize
BU of 7qc5 by Molmil
Crystal structure of human wild type transthyretin in complex with (3,4-dihydroxy-5-nitrophenyl)-(3-fluoro-5-hydroxyphenyl)methanone compound
Descriptor: (3-fluoranyl-5-oxidanyl-phenyl)-[3-nitro-4,5-bis(oxidanyl)phenyl]methanone, Transthyretin
Authors:Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D.
Deposit date:2021-11-22
Release date:2022-11-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation.
J.Med.Chem., 65, 2022
8PMA
DownloadVisualize
BU of 8pma by Molmil
Crystal structure of human V30M transthyretin in complex with PITB (Pharmacokinetically Improved TTR Binder)
Descriptor: (3-fluoranyl-5-oxidanyl-phenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin
Authors:Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D.
Deposit date:2023-06-28
Release date:2024-05-08
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties.
Eur.J.Med.Chem., 261, 2023
4HIS
DownloadVisualize
BU of 4his by Molmil
The Structure of V122I Mutant Transthyretin in Complex with Tafamidis
Descriptor: 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin
Authors:Connelly, S, Alhamadsheh, M, Graef, I, Wilson, I.A.
Deposit date:2012-10-11
Release date:2013-06-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin.
Proc.Natl.Acad.Sci.USA, 110, 2013
3M1O
DownloadVisualize
BU of 3m1o by Molmil
Human Transthyretin (TTR) complexed with 2-((3,5-dichloro-4-hydroxyphenyl)amino)benzoic acid
Descriptor: 2-[(3,5-dichloro-4-hydroxyphenyl)amino]benzoic acid, Transthyretin
Authors:Kolstoe, S.E, Wood, S.P.
Deposit date:2010-03-05
Release date:2010-11-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Trapping of palindromic ligands within native transthyretin prevents amyloid formation.
Proc.Natl.Acad.Sci.USA, 107, 2010
5DWP
DownloadVisualize
BU of 5dwp by Molmil
Crystal Structure of human transthyretin (TTR) processed with the CrystalDirect automated mounting and cryo-cooling technology
Descriptor: Transthyretin
Authors:Zander, U, Cornaciu, I, Forsyth, T, Yee, A, Marquez, J.A.
Deposit date:2015-09-22
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Automated harvesting and processing of protein crystals through laser photoablation.
Acta Crystallogr D Struct Biol, 72, 2016
5JID
DownloadVisualize
BU of 5jid by Molmil
Crystal Structure of Human Transthyretin in Complex with Perfluorooctanoic acid (PFOA)
Descriptor: SODIUM ION, Transthyretin, pentadecafluorooctanoic acid
Authors:Begum, A, Zhang, J, Olofsson, A, Andersson, P, Sauer-Eriksson, A.E.
Deposit date:2016-04-22
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin.
Environ. Sci. Technol., 50, 2016
6SUG
DownloadVisualize
BU of 6sug by Molmil
Crystal structure of transthyretin in complex with 3-deoxytolcapone, a tolcapone analogue
Descriptor: 3-deoxytolcapone, Transthyretin
Authors:Loconte, V, Cianci, M, Menozzi, I, Sbravati, D, Sansone, F, Casnati, A, Berni, R.
Deposit date:2019-09-14
Release date:2020-08-05
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Interactions of tolcapone analogues as stabilizers of the amyloidogenic protein transthyretin.
Bioorg.Chem., 103, 2020
5CM1
DownloadVisualize
BU of 5cm1 by Molmil
X-ray structure of perdeuterated TTR mutant - T119M at 1.22A
Descriptor: Transthyretin
Authors:Yee, A.W, Moulin, M, Mossou, E, Haertlein, M, Mitchell, E.P, Cooper, J.B, Forsyth, V.T.
Deposit date:2015-07-16
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:X-ray structure of perdeuterated TTR mutant - T119M at 1.22A
To Be Published
4HJS
DownloadVisualize
BU of 4hjs by Molmil
Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)ethanesulfonamide
Descriptor: N-{4-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}ethanesulfonamide, Transthyretin
Authors:Connelly, S, Wilson, I.A.
Deposit date:2012-10-14
Release date:2013-12-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis.
J.Am.Chem.Soc., 135, 2013
4FI8
DownloadVisualize
BU of 4fi8 by Molmil
Kinetic Stabilization of transthyretin through covalent modification of K15 by 4-bromo-3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-benzenesulfonamide
Descriptor: 4-bromo-3-[5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]benzenesulfonyl fluoride, Transthyretin
Authors:Connelly, S, Grimster, N, Wilson, I.A, Kelly, J.W.
Deposit date:2012-06-08
Release date:2013-02-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate.
J.Am.Chem.Soc., 135, 2013

221051

PDB entries from 2024-06-12

PDB statisticsPDBj update infoContact PDBjnumon