7DT3

Crystal structure of human transthyretin in complex with 4-chloro-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid

Summary for 7DT3

• Entry DOI: 10.2210/pdb7dt3/pdb
• Descriptor: Transthyretin, CALCIUM ION, 4-chloranyl-9,10-bis(oxidanylidene)anthracene-2-carboxylic acid, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, t4-binding, amyloidosis, transport protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 35274.53

Authors

Kitakami, R.,Yokoyama, T.,Mizuguchi, M. (deposition date: 2021-01-04, release date: 2021-10-13, Last modification date: 2023-11-29)

• Primary citation: Kitakami, R.,Inui, K.,Nakagawa, Y.,Sawai, Y.,Katayama, W.,Yokoyama, T.,Okada, T.,Kanamitsu, K.,Nakagawa, S.,Toyooka, N.,Mizuguchi, M.; Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis.; Bioorg.Med.Chem., 44:116292-116292, 2021; PubMed: 34225167; DOI: 10.1016/j.bmc.2021.116292

Experimental method

X-RAY DIFFRACTION (1.198 Å)