6SUG
Crystal structure of transthyretin in complex with 3-deoxytolcapone, a tolcapone analogue
Summary for 6SUG
Entry DOI | 10.2210/pdb6sug/pdb |
Descriptor | Transthyretin, 3-deoxytolcapone (3 entities in total) |
Functional Keywords | amyloidosis, tetramer, binding protein, transport protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 32324.45 |
Authors | Loconte, V.,Cianci, M.,Menozzi, I.,Sbravati, D.,Sansone, F.,Casnati, A.,Berni, R. (deposition date: 2019-09-14, release date: 2020-08-05, Last modification date: 2024-01-24) |
Primary citation | Loconte, V.,Cianci, M.,Menozzi, I.,Sbravati, D.,Sansone, F.,Casnati, A.,Berni, R. Interactions of tolcapone analogues as stabilizers of the amyloidogenic protein transthyretin. Bioorg.Chem., 103:104144-104144, 2020 Cited by PubMed: 32791384DOI: 10.1016/j.bioorg.2020.104144 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.21 Å) |
Structure validation
Download full validation report