4KY2

Transthyretin in complex with the fluorescent folding sensor (E)-7-hydroxy-3-(4-hydroxy-3,5-dimethylstyryl)-4-methyl-2H-chromen-2-one

Summary for 4KY2

• Entry DOI: 10.2210/pdb4ky2/pdb
• Related: 1DVS 3CN0 3CN1 3CN3 3CN4
• Descriptor: Transthyretin, 7-hydroxy-3-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]-4-methyl-2H-chromen-2-one (3 entities in total)
• Functional Keywords: tetramer, hormone, transport protein, t4, retinol binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 2
• Total formula weight: 28199.43

Authors

Connelly, S.,Wilson, I.A.,Choi, S. (deposition date: 2013-05-28, release date: 2013-08-28, Last modification date: 2023-09-20)

Primary citation

Myung, N.,Connelly, S.,Kim, B.,Park, S.J.,Wilson, I.A.,Kelly, J.W.,Choi, S.
Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors.
Chem.Commun.(Camb.), 49:9188-9190, 2013

PubMed Abstract: We describe coumarin derivatives that are non-fluorescent in aqueous buffers and that very selectively bind to transthyretin (TTR) in complex biological environments potently inhibiting TTR amyloidogenesis while also exhibiting sensitive off-on fluorescent sensing of the properly folded quaternary structure of TTR.

PubMed: 23989101
DOI: 10.1039/c3cc44667k

Experimental method

X-RAY DIFFRACTION (1.13 Å)