8C86

Crystal structure of human transthyretin in complex with 3-O-methyltolcapone analogue 2

Summary for 8C86

Entry DOI	10.2210/pdb8c86/pdb
Related	6SUH
Descriptor	Transthyretin, (2,4-dimethylphenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone (3 entities in total)
Functional Keywords	amyloidosis, tetramer, binding protein, transport protein, lipid binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	28159.32
Authors	Poonsiri, T.,Benini, S.,Loconte, V.,Cianci, M. (deposition date: 2023-01-18, release date: 2024-01-17, Last modification date: 2024-01-24)
Primary citation	Poonsiri, T.,Dell'Accantera, D.,Loconte, V.,Casnati, A.,Cervoni, L.,Arcovito, A.,Benini, S.,Ferrari, A.,Cipolloni, M.,Cacioni, E.,De Franco, F.,Giacche, N.,Rinaldo, S.,Folli, C.,Sansone, F.,Berni, R.,Cianci, M. 3-O-Methyltolcapone and Its Lipophilic Analogues Are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity. Int J Mol Sci, 25:-, 2023 Cited by PubMed: 38203650 DOI: 10.3390/ijms25010479 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.1 Å)

Structure validation